A double-blind placebo-controlled study on the effects of omeprazole on gut hormone secretion and gastric emptying rate

Scandinavian Journal of Gastroenterology

Volumn 32, Issue 9, 1997, Pages 900-905

  Rasmussen, L ^a   Qvist, N ^b   Oster Jorgensen E ^b   Rehfeld, J F ^b   Holst, J J ^b   Pedersen, S A ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Cholecystokinin; Gastrin; Gastroduodenal motillty; Motilin; Scintigraphy

Indexed keywords

CHOLECYSTOKININ; GASTRIN; GASTROINTESTINAL HORMONE; INDIUM 111; MOTILIN; OMEPRAZOLE; PLACEBO; TECHNETIUM 99M;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUODENUM SECRETION; FOOD INTAKE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL SECRETION; GASTROINTESTINAL TRACT SCINTISCANNING; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EMPTYING;

EID: 0030770588     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529709011199     Document Type: Article

References (20)

1. Piper DW, Fenton BH. pH stability and activity curves of pepsin with special reference to their clinical importance. Gut 1965;6: 506-8.
2. Vidon N, Dutreuil C, Scoule JC, Delchier JC. Does lansoprazole influence postprandial digestive function? Aliment Pharmacol Ther 1993;7:629-34.
3. Konturek JW, Mazcka M, Stoll R, Konturek SJ. Cholecystokinin (CCK) in the inhibition of gastric acid secretion and gastrin release in response to meal of low and high pH in healthy subjects and duodenal ulcer subjects [abstract]. Gastroenterology 1994;106:A110.
4. Masclee AAM, Jansen JBMJ, Driessen WMM, Geuskens LM, Lamers CBHW. Effect of truncal vagotomy on cholecystokinin release, gallbladder contraction, and gallbladder sensitivity to cholecystokinin in humans. Gastroenterology 1990;98:1338-44.
5. Svenberg T, Nilsson I, Samuelson K, Welbourn RD. Studies on the causal relationship between gall-bladder emptying and motilin release in man. Acta Chir Scand 1984;520:59-61.
6. Jian R, Lemann M, Lemaire M, Flourie B. Effect of a new H + K + ATPase Blocker (RU 749) on gastric empyting in man [abstract]. Gastroenterology 1989;96:A240.
7. Horowitz M, Hetzel DJ, Buckle PJ, Chatterton BE, Shearman DJC. The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease. Br J Clin Pharmacol 1984;18:791-94.
8. Rehfeld JF, Stadil F, Rubin B. Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand J Clin Lab Invest 1972;40:221-32.
9. Cantor P. Evaluation of a radioimmunoassay for cholecystokinin in human plasma. Scand J Clin Lab Invest 1986;46:221-31.
10. Qvist N, Øster-Jørgensen E, Pedersen SA, Rasmussen L, Hovendal CP, Holst JJ. Increases in plasma motilin follow each episode of gallbladder emptying during the interdigestive period and changes in serum bile acid concentration correlate to plasma motilin. Scand J Gastroenterol 1995;30:122-27.
11. Dammann HG, Richter G, Wolf N, Burkhardt F. Influence of lansoprazole 15 and 30 mg and omeprazole 20 and 40 mg on meal-stimulated gastric acid secretion [abstract]. 4th United European Gastroenterology Week, 1995.
12. Woodtli W, Owyang C. Duodenal pH governs interdigestive motility in humans. Am J Physiol 1995;268:G146-52.
13. Qvist N, Øster-Jørgensen E, Rasmussen L, Pedersen SA, Olsen O, Cantor P, et al. Cholecystokinin, secretin, pancreatic polypeptide in relation to gallbladder dynamics and gastrointestinal interdigestive motility. Digestion 1990;45:130-37.
14. Schmidt WE, Schenk S, Nustede R, Holst JJ, Fölsch UR, Creutzfeldt W. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans. Gastroenterology 1994;107:1610-20.
15. Xing JH, Ke MY, Zhang SQ. The effects of omeprazole on gastric emptying and gallbladder motility in healthy subjects and patients with reflux esophagitis [abstract]. 10th World Congress of Gastroenterology, 1994, Los Angeles, USA.
16. O'Donnell LJD, Fairclough PD. Gallstones and gallbladder motility. Gut 1993;34:440-3.
17. Hall KE, El-Sharkawy TY, Diamant NE. Vagal control of canine postprandial upper gastrointestinal motility. Am J Physiol 1986;250:G501-10.
18. Rasmussen L, Øster-Jørgensen E, Qvist N, Holst JJ, Rehfeld JF, Hovendal CP, et al. The relationship between gut hormone secretion and gastric emptying in different phases of the migrating motor complex. Scand J Gastroenterol 1996;31:458-62.
19. Boivin M, Bradette M, Raymond MC, Riberdy-Poitras M, Poitras P. Mechanisms for postprandial release of motilin in humans. Dig Dis Sci 1992;37:1562-8.
20. Christofides ND, Long RG, Fitzpatrick ML, Mc Gregor GP, Bloom SR. Effect of motilin on the gastric emptying of glucose and fat in humans. Gastroenterology 1981;80:456-60.