Better comparisons of antiepileptic drugs: What measures of efficacy?

Pharmacy World and Science

Volumn 19, Issue 5, 1997, Pages 214-216

  Chadwick, David ^a  

^a WALTON CENTRE FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Effectiveness; Efficacy; Quality of life

Indexed keywords

ANTICONVULSIVE AGENT;

ARTICLE; DRUG EFFICACY; DRUG TOLERABILITY; EPILEPSY; HUMAN; MEASUREMENT; PRACTICE GUIDELINE; QUALITY OF LIFE; TREATMENT OUTCOME;

ANTICONVULSANTS; CLINICAL TRIALS; HUMANS; QUALITY OF LIFE; THERAPEUTIC EQUIVALENCY;

EID: 0030770584     PISSN: 09281231     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008642623460     Document Type: Article

References (8)

1. Commission for Antiepileptic Drugs. Guidelines for the Clinical Evaluation of Antiepileptic Drugs. Epilepsia 1989;30: 400-06.
2. Mattson RH, Cramer JA, Collins JF, et al. Comparison of carbamazepine, phenobarbital, phenytoin and primidone in partial and secondarily generalized tonic-clonic seizures. New England Journal of Medicine 1985;313: 145-51.
3. Mattson RH, Cramer JA, Collins JF, et al. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. New England Journal of Medicine 1992;327: 765-771.
4. Jacoby A, Baker GA, Steen N, Potts P, Chadwick DW. The clinical course of epilepsy and its psychological correlates: Findings from a UK Community Study. Epilepsia 1996;37 (2): 148-61.
5. Fraught E, Sachdeo RC, Remler MP, Chayasirisobhon S, Iragui, Madoz VJ, Ramsey RE, Sutula TP, Kanner A, Harner RN, Kuzniecky R, et al. Felbamate monotherapy for partial onset seizures: an active control trial. Neurology Apr 1993;43 (4): 688-92.
6. Sachdeo R, Kramer LD, Rosenberg A, and Sachdeo S. (1992) Felbamate monotherapy: controlled trial in patients with partial onset seizures. Ann Neurol. Sep 1992;32 (3): 386-92.
7. Heller AJ, Stewart J, Hughes E, et al. (1995) Comparative efficacy and toxicity of phenobarbital, phenytoin, carbamazepine and valproate in adults and children with newly diagnosed previously untreated epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 1995;58: 44-50.
8. Jones B, Jarvis P, Lewis JA, et al. Trials to assess equivalence: the importance of rigorous methods. British Medical Journal 1996; 313: 36-9.