Induction of a cAMP-stimulated chloride secretion in regenerating poorly differentiated airway epithelial cells by adenovirus-mediated CFTR gene transfer

Human Gene Therapy

Volumn 8, Issue 12, 1997, Pages 1439-1450

  Dupuit, Florence ^a   Chinet, Thierry ^b   Zahn, Jean Maria ^a   Pierrot, Denis ^a   Hinnrasky, Jocelyne ^a   Kaplan, Herve ^a   Bonnet, Noel ^a   Puchelle, Edith ^a,c  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b HÔPITAL AMBROISE PARÉ   (France)

^c HÔPITAL MAISON BLANCHE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP; QUINOLINE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CELL REGENERATION; CELL STIMULATION; CHLORIDE TRANSPORT; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; LASER MICROSCOPY; NONHUMAN; PATCH CLAMP; PROTEIN LOCALIZATION; RESPIRATORY EPITHELIUM;

ADENOVIRIDAE;

EID: 0030770327     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.12-1439     Document Type: Article

References (3)

1. BALTIMORE, R.S., CHRISTIE, C.D.C., and SMITH, G.J.W. (1989). Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for pathogenesis of progressive deterioration. Am. Rev. Respir. Dis. 140, 1650-1661.
2. BOUT, A., IMLER, J.-L., SCHULTZ, H., PERRICAUDET, M., ZURCHER, C., HERBRINK, P., VALERIO, D., and PAVIRANI, A. (1994). In vivo adenovirus-mediated transfer of human CFTR cDNA to Rhesus monkey airway epithelium: efficacy, toxicity and safety. Gene Ther. 1, 385-394.
3. BRÉZILLON, S., DUPUIT, F., HINNRASKY, J., MARCHAND, V., KÄLIN, N., TÜMMLER, B., and PUCHELLE, E. (1995). Decreased expression of the CFTR protein in remodeled human nasal epithelium from non-cystic fibrosis patients. Lab. Invest. 72, 191-199.