Inhibitory effects of betotastine, a novel anti-allergic drug on histamine-induced bronchoconstriction in anesthetized dogs

Japanese Pharmacology and Therapeutics

Volumn 25, Issue 4, 1997, Pages 25-30

  Matsubara, Shigeki ^a   Ono, Chizuko ^b   Yamazaki, Noriyuki ^b   Kashiyama, Naoki ^b   Kikkawa, Hideo ^a   Kikuchi, Matsuo ^a   Naito, Kazuaki ^a   Ikezawa, Katsuo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b New Drug Devmt Res Center Inc   (Japan)

Author keywords

Anti allergic drug; Betotastine; Dog; Histamine induced bronchoconstriction

Indexed keywords

ANTIALLERGIC AGENT; BETOTASTINE; CETIRIZINE; HISTAMINE; KETOTIFEN; TERFENADINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BRONCHOSPASM; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; INTRADUODENAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN;

EID: 0030770271     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. National Heart, Lung and Blood Institute, NIH, Global Initiative for Asthma, Global Strategy for Asthma Management and Prevention, NHLBI/ WHO Workshop Report, National Institutes of Health, Publication Number 95 3659, 1995
2. Woodward JK, Munro NL : Terfenadine, the first non sedating antihistamine. Arzneim-Forsch/Drug Res 32 : 1154-1156, 1982
3. Mctavish D et al : Terfenadine ; An updated review of its pharmacological properties and therapeutic efficacy. Drugs 39 : 552-574, 1990
4. Classod SP et al : Loratadine ; A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs 37 : 42-57, 1989
5. Nightingale SL : From the Food and Drug Administration ; Warnings issued on nonsedating antihistamines terfenadine and astemizole. JAMA 268 : 705, 1992
6. Kato M et al : Effect of betotastine, a new antiallergic agent, on the central nervous system. Arzneim-Forsch/Drug Res (in submitted)
7. Konzett H, Rössler R : Experimental procedure for the investigation of bronchial muscle. Naunyn-Schmiedeberg's Arch Exp Pathol Pharmacol 195 : 71-74, 1940
8. Kari TK et al : Inhibition of terfenadine metabolism ; Pharmacokinetic and pharmacodynamic consequences. Clin Pharmacokinet 27 : 1-5, 1994
9. Martin U, Römer D : The pharmacological properties of a new, orally active antianaphylactic compound ; Ketotifen, a benzocycloheptathiophene. Arzneim-Forsch/Drug Res 28(1) : 770-782, 1978
10. Bigot JF et al : Species differences in metabolism of ketotifen in rat, rabbit and man ; Demonstration of similar pathways in vivo and in cultured hepatocytes. Life Sci 40 : 883-890, 1987
11. 2 in perfused guinea-pig lungs. Br J Pharmacol 65 : 629-633, 1979