Differences in the prevalence of a TaqI RFLP in the 3' flanking region of the α1-proteinase inhibitor gene between asthmatic and non-asthmatic black and white South Africans

Clinical Genetics

Volumn 52, Issue 3, 1997, Pages 162-166

  Green, Samantha L ^a   Gaillard, M Christine ^b   Dewar, John B ^a   Ludewick, Herbert ^c   Song, Ernest ^b   Feldman, Charles ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

^c South African Institute of Medical Research   (South Africa)

Author keywords

Aipha 1 proteinase inhibitor; Asthma; Tag I( ) allele

Indexed keywords

PROTEINASE INHIBITOR; RESTRICTION ENDONUCLEASE;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CAUCASIAN; CHILD; DNA FLANKING REGION; FEMALE; GENE; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; NEGRO; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STUDY;

EID: 0030770223     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1997.tb02537.x     Document Type: Article

References (20)

1. American Thoracic Society Statement: chronic bronchitis, asthma and pulmonary emphysema. Am Rev Respir Dis 1962: 85: 762-768.
2. Barnes PJ. Drug therapy: a new approach to the treatment of asthma. N Engl J Med 1989: 321: 1517-1527.
3. Barnes PJ. Asthma: what is left to find out? BMJ 1993: 307: 814-815.
4. Brantly M, Nukiwa T, Crystal RG. Molecular basis of alpha-1-antitrypsin deficiency. Am J Med 1988: 84(Suppl 6A): 13-31.
5. 1-antitrypsin on the proliferative response of human peripheral blood lymphocytes. J Immunol 1983: 130: 681-686.
6. 1-antichymotrypsin and is stimulated by proteinases. J Exp Med 1988: 168: 1293-1306.
7. 1-antitrypsin in Puerto Rican children with asthma. Chest 1993: 103: 312-315.
8. C5. Hum Genet 1980: 55: 111-114.
9. 1-Antitrypsin deficiency. In: Scriver CR, Baudet AL, Fly WS, Valle D, eds. The metabolic and molecular basis of inherited disease, vol. 2. New York: McGraw-Hill, 1995, 2409-2437.
10. Gaillard MC, Kilroe-Smith TA, Nogueira C, Dunn D, Jenkins T, Fine B, Kallenbach J. Alpha-1-protease inhibitor in bronchial asthma: phenotypes and biochemical characteristics. Am Rev Respir Dis 1992: 145: 1311-1315.
11. 213) haplotype of alpha-1-antitrypsin in asthmatic and non-asthmatic black and white South Africans. Clin Genet 1994: 45: 122-127.
12. Higuchi R. Rapid and efficient DNA extraction for PCR from cells or blood. Amplifications 1989: 2: 1-12.
13. Holgate ST, Finnerty JP. Recent advances in understanding the pathogenesis of asthma and its clinical implications. J Med 1988: 249: 5-19.
14. 1-antitrypsin gene in chronic lung disease. BMJ 1987: 294: 1511-1514.
15. Matteson HJ, Ostrer H, Chikravarti A. A study of restriction fragment length polymorphisms at the human alpha-1-antitrypsin locus. Hum Genet 1985: 69: 263-267.
16. Morgan K, Scobie G, Kalsheker NA. Point mutation in a 3′ flanking sequence of the alpha-1-antitrypsin gene associated with chronic respiratory disease occurs in a regulatory sequence. Hum Mol Genet 1993: 2: 253-257.
17. Pinto AR, Maciel LS, Carniero F, Resende C, Chaves FC, Freitas AF. Systemic nodular panniculitis in a patient with alpha-1-antitrypsin deficiency (PiSS phenotype). Clin Exp Dermatol 1993: 18: 154-155.
18. Scheffer AL. Guidelines for the management of asthma. Allergy & Clin Immunol 1991: 88(Suppl): 427-438.
19. Shulman G. Comparison of specific protein assays in biological fluids by radial immunodiffusion and laser nephelometry. Clin Biochem 1979: 12: 123-125.
20. Tilg H, Vannier E, Vachino G, Dinarello CA, Mier JW. Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin-1 (IL-1) receptor antagonist over Il-1β synthesis by human peripheral blood mononuclear cells. J Exp Med 1993: 178: 1629-1636.