Animal models for nervous system disease in systemic lupus erythematosus

Annals of the New York Academy of Sciences

Volumn 823, Issue , 1997, Pages 97-106

  Brey, Robin L ^a   Sakic, Boris ^b   Szechtman, Henry ^b   Denburg, Judah A ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; ETIOLOGY; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALIA; MURINAE;

EID: 0030770036     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48382.x     Document Type: Conference Paper

References (55)

1. THEOFILOPOULOS, A. N. 1992. Murine models of lupus. In Systemic Lupus Erythematosus. R. G. Lahita, Ed. 121-194. Churchill Livingstone. New York.
2. KLINMAN, D. M. & A. D. STEINBERG. 1995. Inquiry into murine and human lupus. Immunol. Rev. 144: 157-193.
3. SHOENFELD, Y., M. BLANK, R. AHARONI, D. TEITELBAUM & R. ARNON, 1993. Manipulation of autoimmune diseases with T-suppressor cells: Lesions from experimental SLE and EAE. Immunol. Lett. 36: 109-116.
4. PIERANGELI, S. S. & E. N. HARRIS. 1996. In vivo models of thrombosis for the antiphospholipid syndrome. Lupus 5: 451-455.
5. KRAUSE, I., M. BLANK & Y. SHOENFELD. 1996. Immunointerventions in experimental model for antiphospholipid syndrome. Ann. Intern. Med. 147: 50-53.
6. MERINO, R., M. IWAMOTO, L. FOSSATI, P. MUNIESA, K. ARAKI, S. TAKAHASHI et al. 1993. Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E α-chain. J. Exp. Med. 178: 1189.
7. WANTANABE-FUKUNAGA, R., C. I. BRANNAN, N. G. COPELAND, N. A. JENKINS & S. NAGATA. 1992. Lymphoproliferation disorder in mice explained by defects in fast antigen that mediates apoptosis. Nature 356: 314.
8. MOZES, E., L. D. KOHN, F. HAKIM & D. S. SINGER. 1993. Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus. Science 261: 91-93.
9. SAKIC B., H. SZECHTMAN & J. A. DENBURG. Neurobehavioral alteration in autoimmune mice. Neurosci. Biobehav. Rev. In press.
10. SZECHTMAN, H., B. SAKIC & J. A. DENBURG. Behavior of MRL mice: An animal model of disturbed behavior in systemic autoimmune disease. Neurosci. Biobehav. Rev. In press.
11. LAMPERT, P. & M. B. OLDSTONE. 1973. Host immunoglobulin IgG and complement deposits in the choroid plexus during spontaneous immune complex disease. Science 180: 408-410.
12. ALEXANDER, E. L., E. D. MURPHY, J. B. ROTHS & G. E. ALEXANDER. 1983. Congenic autoimmune murine models of central nervous system disease in connective tissue disorders. Ann. Neurol. 14: 242-248.
13. RUDICK, R. A. & T. A. ESKIN. 1983. Neuropathological features of a lupus-like disorder in autoimmune mice. Ann. Neurol. 14: 325-332.
14. HOFFMAN, S. A., D. N. ARBOGAST, P. M. FORD, D. W. SHUCARD & R. J. HARBECK. 1987. Brain-reactive autoantibody levels in the sera of ageing autoimmune mice. Clin. Exp. Immunol. 70: 74-83.
15. NANDY, K., H. LAL, M. BENNETT & D. BENNETT. 1983. Correlation between a learning disorder and elevated brain-reactive antibodies in aged C57BL/6 and young NZB mice. Life Sci. 33: 1499-1503.
16. MOORE, P. M. 1990. Immunoglobulin binding to neuronal cell surface epitopes in murine systemic lupus erythematosus. J. Neuroimmunol. 30: 101-109.
17. MOORE, P. M. 1992. Evidence for bound antineuronal antibodies in brains of NZB/W mice. J. Neuroimmunol. 38: 147-154.
18. KHIN, N. A. & S. T. HOFFMAN. 1993. Brain reactive monoclonal auto-antibodies: Production and characterization. J. Neuroimmunol. 44: 137-148.
19. HESS, D. C., M. TAORMINA, J. THOMPSON, K. D. SETHI, B. DIAMOND, R. RAO & D. S. FELDMAN. 1993. Cognitive and neurologic deficits in the MRL/lpr mouse: A clinicopathologic study. J. Rheumatol. 20: 610-617.
20. BREY, R. L., S. COTE & J. M. TEALE. 1993. Neurological dysfunction and autoantibody-producing B cells from brain in a lupus-prone mouse strain. Neurology 43: 420.
21. SCHROTT, L. M., L. MORRISON, R. WIMER, C. WIMER, P. O. BEHAN & V. H. DENENBERG. 1994. Autoimmunity and avoidance learning in NXRF recombinant inbred strains. Brain Behav. Immun. 8: 100-110.
22. FORSTER, M. J., K. C. RETZ & H. LAL. 1988. Learning and memory deficits associated with autoimmunity: Significance in aging and Alzheimer's disease. Drug Dev. Res. 15: 253-273.
23. SAKIC, B., H. SZECHTMAN, S. D. DENBURG, R. M. CARBOTTE & J. A. DENBURG. 1993. Brain-reactive antibodies and behavior of autoimmune MRL-lpr mice. Physiol. & Behav. 54: 1025-1029.
24. KIER, A. B. 1990. Clinical neurology and brain histopathology I NZB/NZW F1 lupus mice. J. Comp. Pathol. 102: 165-177.
25. MCINTYRE, K. R., C. AYER-LELIEVRE & H. PERSSON. 1990. Class II major histocompatibility complex (MHC) gene expression in the mouse brain is elevated in the autoimmune MRL/Mp-lpr/lpr strain. J. Neuroimmunol. 28: 39-52.
26. TANG, B., T. MATSUDA, S. AKIRA, N. NAGATA, S. IKEHARA, T. HIRANO & T. KISHIMOTO. 1991. Age-associated increase in interleukin 6 in MRL/lpr mice. Int. Immunol. 3: 273-278.
27. COTE, S. A., J. CLAY-FLORES, R. TANGUMA & R. L. BREY. 1995. Intact blood-brain barrier in an autoimmune-prone mouse strain with antineuronal membrane protein antibodies and central nervous system dysfunction. Neurology 45: 205.
28. VOGELWEID, C. M., G. C. JOHNSON, C. L. BESCH-WILLIFORD, J. BASLER & S. E. WALKER. 1991. Inflammatory central nervous system disease in lupus-prone MRL/lpr mice: Comparative histologic and immunohistochemical findings. J. Neuroimmunol. 35: 89-99.
29. SAKIC, B., L. GURUNLIAN, J. A. DENBURG & H. SZECHTMAN. 1996. Impaired fighting behavior in autoimmune MRLlpr mice. Soc. Neurosci. In press.
30. SAKIC, B., H. SZECHTMAN, M. KEFFER, H. TALANOBAYAN, R. STEAD & J. A. DENBURG. 1992. A behavioral profile of autoimmune lupus-prone MRL mice. Brain Behav. Immun. 6: 265-285.
31. SAKIC, B., H. SZECHTMAN, H. TALANGBAYAN, S. D. DENBURG, R. M. CARBOTTE & J. A. DENBURG. 1994a. Behaviour and immune status of MRL mice in the postweaning period. Brain Behav. Immunol. 8: 1-13.
32. SAKIC, B., H. SZECHTMAN, R. STEAD & J. A. DENBURG. 1996. Joint pathology and behavioral performance in autoimmune MRL-lpr mice. Physiol. & Behav. 60: 901-905.
33. SAKIC, B., H. SZECHTMAN, H. TALANGBAYAN, S. D. DENBURG, R. M. CARBOTTE & J. A. DENBURG. 1994b. Disturbed emotionality in autoimmune MRL-lpr mice. Physiol. & Behav. 56: 609-617.
34. SAKIC, B., J. A. DENBURG, S. D. DENBURG & H. SZECHTMAN. 1996. Blunted sensitivity to sucrose reward in autoimmune MRL-lpr mice: A curve-shift study. Brain Res. Bull. 41:305-311.
35. SAKIC, B., H. SZECHTMAN, T. A. BRACIAK, C. D. RICHARDS, J. GAULDIE & DENBURG, J. A. 1996. Role of interleukin-6 in the reduced preference for sucrose in autoimmune mice. Behav. Neurosci. Submitted.
36. O'SULLIVAN, F. X, H. G. FASSBENDER, S. GAY & W. J. KOOPMAN. 1985. Etiopathogenesis of the rheumatoid arthritis-like disease in MRL/1 mice. I. The histomorphologic basis of joint destruction. Arthritis Rheum. 28: 529-536.
37. CRNIC, L. S. & L. M. SCHROTT. 1996. Increased anxiety behaviors in autoimmune mice. Behav. Neurosci. 110: 492-502.
38. KENT, M., E. VOGT & N. S. ROTE. 1994. Monoclonal antiphospholipid antibodies react directly with cat brain. Lupus 3: 315.
39. LIOU, H. H., C. R. WANG, H. C. CHOU et al. 1994. Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-medicated chloride current in snail neurons. Life Sci. 54: 1119-1125.
40. GHARAVI, A. E., L. R. SAMMARITANO, J. WEN & K. B. ELKON. 1992. Induction of antiphospholipid antibodies by immunization with β2-glycoprotein I (apolipoprotein H). J. Clin. Invest. 90: 1105-1109.
41. ZIPOREN, L., D. EILAM, I. GOLDBERG, A. AFEK, S. POLAK, A. BARDEA, A. MIKE, Y. KOPOLOVIC, A. D. KORZCYN & Y. SHOENFELD. 1996. Neurological dysfunctions associated with antiphospholipid antibodies: Animal model. Lupus 5: 533.
42. TINCANI, A. & Y. SHOENFELD. 1996. Animal models of the antiphospholipid syndrome. The antiphospholipid syndrome. Lupus 5: 71-82.
43. SMITH, H. R., C. L. HANSEN, R. ROSE & R. T. CANOSO. 1990. Autoimmune MRL/lpr/lpr mice are an animal model for the secondary antiphospholipid syndrome. J. Rheumatol. 17: 911-915.
44. COTE, S A, R. L. BREY & J. M. TEALE. 1994. Autoimmune disease is accelerated in MRL/++ mice after apoH immunization. Lupus 3: 337.
45. BREY, R. L., S. A. COTE, L. ZHONGREN & J. TEALE. 1995. Central nervous system dysfunction is accelerated in autoimmune-prone mice immunized with neuronal surface proteins. Neurology 45: 205.
46. ARON, A. L., M. L. CUELLAR, R. L. BREY, A. E. GHARAVI & Y. SHOENFELD. 1995. Early onset of autoimmumty in MRL/++ mice following immunization with beta-2-glycoprotein 1. Clin. Exp. Rheum. Immunol. 101: 78-81.
47. RUIZ, P. J., H. ZINGER & E. MOZES. 1996. Effect of infection of anti-CD4 and anti-CD8 monoclonal antibodies on the development of experimental systemic lupus erythematosus in mice. Cell. Immunol. 167: 30-37.
48. FISHMAN, P. & Y. SHOENFELD. 1996. Aspirin, interleukin-3 and the antiphospholipid syndrome. Isr. J. Med. Sci. 32: 13-17.
49. FISHMAN, P., E. FALACH-VAKNINE, R. ZIDELMAN, R. BAKIMER, R. SREDNI, M. DJALDETTI & Y. SHOENFELD. 1993. Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3. J. Clin. Invest. 91: 1834-1837.
50. SUZUKA, H., H. FUJIWARA, M. TANAKA, H. YOSHIFUSA, Y. NAKAMURA & Y. SHIBATA. Antithrombotic effect of ticlopidine on occlusive thrombi of small coronary arteries in (NZW x BXSB)F1 male mice with myocardial infarction and systemic lupus erythematosus. J. Cardiovasc. Pharm. 25: 9-13.
51. FARRELL, M., B. SAKIC, H. SZECHTMAN & J. A. DENBURG. 1996. Effect of cyclophosphamide on leucocytic infiltration in the brain of MRL/lpr mice. Lupus. In press.
52. SAKIC, B., H. SZECHTMAN, S. D. DENBURG & J. A. DENBURG. 1995. Immunosuppressive treatment prevents behavioral deficit in autoimmune MRL-lpr mice. Physiol. & Behav. 58: 797-802.
53. VOGELWEID, C. M., D. C. WRIGHT, J. C. JOHNSON, J. E. HEWETT & S. E. WALKER. 1994. Evaluation of memory, learning ability, and clinical neurologic function in pathogenfree mice with systemic lupus erythematosus. Arthritis Rheum. 37: 889-897.
54. BREY, R. L., S. COTE, R. BAROHN, C. JACKSON, R. CRAWLEY & J. M. TEALE. 1995. Model for the neuromuscular complications of systemic lupus erythematosus. Lupus 4: 209-212.
55. BREY, R. L., C. B. RHINE, C. STALLWORTH & K. KAGEN-HALLET. 1997. Anti-ICAM-1 antibody treatment has a neuroprotective effect in lupus-prone mice. Neurology 48 (Suppl.): A363.