Stability of phenoxybenzamine hydrochloride in various vehicles

American Journal of Health-System Pharmacy

Volumn 54, Issue 18, 1997, Pages 2073-2078

  Lim, Lee Yong ^a   Tan, Lai Li ^a,b   Chan, Eli W Y ^a   Yow, Kah Lai ^c   Chan, Sui Yung ^a   Ho, Paul C L ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Guardian Pharmacy   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Capsules Citric acid; Compounding; Concentration; Incompatibilities; Liquids; Phenoxybenzamine hydrochloride; Powders; Propylene glycol; Stability; Storage; Sucrose; Sympatholytic agents; Vehicles; Water

Indexed keywords

ALCOHOL; CITRIC ACID; DRUG VEHICLE; GLYCEROL; PHENOXYBENZAMINE; PROPYLENE GLYCOL; SUCROSE;

ARTICLE; DILUTION; DRUG DETERMINATION; DRUG FORMULATION; DRUG SOLUTION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030769883     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/54.18.2073     Document Type: Article

References (11)

1. Taketomo CK, Hodding JH, Kraus DM, eds. Pediatric dosage handbook. 3rd ed. Hudson, OH: Lexi-Comp Ine; 1996:543.
2. Martindale: the extra pharmacopoeia. 28th ed. London: Pharmaceutical Press; 1982:158.
3. Nedergaad M. Phenoxybenzamine in solutions. J Hosp Pharm. 1969; 27:174-6.
4. Adams WP, Kostenbauder HB. Phenoxybenzamine stability in aqueous ethanolic solutions. I. Application of potentiometric pH stat analysis to determine kinetics. Int J Pharm. 1985; 25:293-312.
5. Hagan RL. High-performance liquid chromatography for small-scale studies of drug stability. Am J Hosp Pharm. 1994; 51:2162-75.
6. Pharmaceutical Society of Great Britain. The pharmaceutical codex. 12th ed. London: Pharmaceutical Press; 1994:43.
7. Adams WP, Kostenbauder HB. Phenoxybenzamine stability in aqueous ethanolic solutions. II. Solvent effects upon kinetics. Int J Pharm. 1985; 25:313-27.
8. American Pharmaceutical Association, Pharmaceutical Society of Great Britain. Handbook of pharmaceutical excipients. London: Pharmaceutical Press; 1986:123.
9. American Academy of Pediatrics Committee on Drugs. Ethanol in liquid preparations intended for children. Pediatrics. 1984; 73:405-7.
10. Martin G, Finberg L. Propylene glycol: a potentially toxic vehicle in liquid dosage forms. J Pediatr. 1970; 77:877-8.
11. Bundgaard H, Larsen C. Kinetics and mechanism of the sucrose-accelerated degradation of penicillins in aqueous solution. Int J Pharm. 1978; 1:95-104.