Complement C6 and C2 biosynthesis in syngeneic PVG/c- and PVG/c+ rat strains

Scandinavian Journal of Immunology

Volumn 46, Issue 4, 1997, Pages 366-372

  Timmerman, J J ^a   Van Dixhoorn, M G A ^a   Schraa, E O ^b   Van Gijlswijk Janssen, D J ^a   Muizert, Y ^a   Van Es, L A ^a   Daha, M R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C6;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; IMMUNOREGULATION; INFLAMMATION; LIVER TRANSPLANTATION; MESSENGER RNA SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030769537     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-143.x     Document Type: Article

References (32)

1. Alper CA, Johnson AM, Birtch AG, Moore FD. Human C3: evidence for the liver as the primary site of synthesis. Science 1969;163:286-8.
2. Hobart MJ, Lachmann PJ, Calne RY. C6: synthesis in the liver in vivo. J Exp Med 1977;146:629-30.
3. Alper CA, Raum D, Awdeh ZL, Petersoen BH, Taylor PD, Starzl TE. Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrrin, α1-antitrypsin, C8 and factor B. Clin Immunol Immunopath 1980;16:84-9.
4. Wolpl A, Robin-Winn M, Pichlmayr R, Goldmann SF. Fourth component of complement (C4) polymorphism in human orthotopic liver transplantation. Transplantation 1985;40:154-7.
5. Ellison RT, III, Mason SR, Kohler PF, Curd JG, Reller LB. Meningococcemia and acquired complement deficiency. Arch Intern Med 1986;146:1539-40.
6. Passwell J, Schreiner GF, Nonaka M, Beuscher HU, Colten HR. Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis. J Clin Invest 1988;82:1676-84.
7. Witte DP, Welch TR, Beischel LS. Detection and cellular localization of human C4 gene expression in the renal tubular epithelial cells and other extrahepatic epithelial sources. Am J Pathol 1991;139:717-24.
8. Welch TR, Beischel LS, Witte DP. Differential expression of complement C3 and C4 in the human kidney. J Clin Invest 1993;92:1451-8.
9. Sacks SH, Zhou W, Andrews PA, Hartley B. Endogenous complement C3 synthesis in immune complex nephritis. Lancet 1993;342:1273-4.
10. Dovezenski N, Biletta R, Gigli I. Expression and localization of proteins of the complement system in human skin. J Clin Invest 1992;90:2000-12.
11. Pasinetti GM, Johnson SA, Rozovsky I et al. Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Experiment Neurol 1992;118:117-25.
12. Fey G, Colten HR. Biosynthesis of complement components. Fed Proc 1981;40:2099-104.
13. Wurzner R, Joysey VC, Lachmann PJ. Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7. J Immunol 1994;152:4624-9.
14. Naughton MA, Walport MJ, Würzner R et al. Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans. Eur J Immunol 1996;26:2108-12.
15. Naughton MA, Botto M, Carter MJ, Alexander GJM, Goldman JM, Walport MJ. Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans. J Immunol 1996;156:3051-6.
16. Frank MM. Animal models for complement deficiencies. J Clin Immunol 1995;15:113S-21S.
17. Leenaerts PL, Stad RK, Hall BM, van Damme BJ, Vanrenterghem Y, Daha MR. Hereditary C6 deficiency in a strain of PVG/c rats. Clin Exp Immunol 1994;97:478-82.
18. Brandt J, Pippin J, Schulze M et al. Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int 1996;49: 335-43.
19. Brauer RB, Baldwin WM, III, Wang D et al. Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. J Immunol 1994;153:3168-76.
20. Kamada N, Calne RY. A surgical experience with five hundred and thirty liver transplants in the rat. Surgery 1983;93:64.
21. Southard JH, van Gulik TM, Ametani MS et al. Important components of the UW solution. Transplantation 1990;49:251-7
22. Daha MR, van Es LA. Enhanced alternative pathway-complement dependent degradation of soluble immunoglobulin aggregates by macrophages. Immunology 1981;43:513-8.
23. van Dixhoorn MGA, Timmerman JJ, van Gijlswijk-Janssen DJ, Muizert Y, Verweij CL, Daha MR. Characterization of complement component C6 deficiency in a PVG/c rat strain. Clin Exp Immunol 1997;109:387-96.
24. Timmerman JJ, van der Woude FJ, van Gijlswijk-Janssen DJ, Verweij CL, van Es LA, Daha MR. Differential expression of complement components in human fetal and adult kidneys. Kidney Int 1996;49:730-40.
25. Timmerman JJ, Verweij CL, van Gijlswijk-Janssen DJ, van der Woude FJ, van Es LA, Daha MR. Cytokine-regulated production of the major histocompatibility complex class-III-encoded complement proteins factor B and C4 by human glomerular mesangial cells. Hum Immunol 1995;43:19-28.
26. Feinberg AP, Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983;132:6-13.
27. Ponte P, Ng SY, Engel J, Gunning P, Kedes L. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human β-actin cDNA. Nucleic Acids Res 1984;12:1687-96.
28. Gasque P, Fontaine M, Morgan BP. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J Immunol 1995;154:4726-33.
29. Garred P, Hetland G, Mollnes TE, Stoervold G. Synthesis of C3, C5, C6, C7, C8, and C9 by human fibroblasts. Scan J Immunol 1990;32:555-60.
30. Morris KM, Aden DP, Knowles BB, Colten HR. Complement biosynthesis by the human hepatoma-derived cell line HepG2. J Clin Invest 1982;70:906-13.
31. Hogasen AKM, Wurzner R, Abrahamsen TG, Dierich MP. Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation. J Immunol 1995;154:4734-40.
32. Timmerman JJ, van Dixhoorn MGA, Schraa EO et al. Extrahepatic C6 is as effective as hepatic C6 in the generation of renal C5b-9 complexes. Kidney Int 1997;51:1788-96.