Subcellular localization and translocation of protein kinase C isoforms ζ and ε in human peripheral blood lymphocytes

International Immunology

Volumn 9, Issue 10, 1997, Pages 1431-1439

  Keenan, Carolyn ^a   Volkov, Yuri ^a   Kelleher, Dermot ^a   Long, Aideen ^a  

^a ST JAMES S HOSPITAL   (Ireland)

Author keywords

Cytoskeleton; Protein kinase C ; Protein kinase C ; T lymphocyte; TCR

Indexed keywords

CD3 ANTIGEN; ISOENZYME; OKT 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL MEMBRANE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE ACTIVATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD3; BIOLOGICAL TRANSPORT, ACTIVE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; RECEPTORS, ANTIGEN, T-CELL; SUBCELLULAR FRACTIONS; TETRADECANOYLPHORBOL ACETATE;

EID: 0030768585     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.10.1431     Document Type: Article

References (32)

1. Crabtree, G. R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science 243:355.
2. Berry, N. and Nishizuka, Y. 1990. Protein kinase C and T cell activation. Eur. J. Biochem. 89:205.
3. Murphy, A., Breen, K. C., Long, A., Feighery, C., Casey, E. B. and Kelleher, D. 1993. Neurofilament expression in human T lymphocytes. Immunology 79:167.
4. Nishizuka, Y. 1995. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:484.
5. Gupta, S. and Harris, W. 1994. Phorbol myristate acetate-induced changes in protein kinase C isozymes (α, β, γ and ζ) in human T cell subsets. Adv. Exp, Med. Biol. 365:143.
6. Baier, G., Telford, D., Giampa, L., Coggeshall, K .M., Baier-Bitterlich, G., Isakov, N. and Altman, A. 1993. Molecular cloning and characterization of PKC θ, a novel member of the protein kinase C gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268:4997.
7. Tsutsumi, A., Kubo, M., Fujii, H., Freire-Moar, J., Turck, C. W. and Ransom, J. T. 1993. Regulation of protein kinase C isoform proteins in phorbol ester-stimulated Jurkat T lymphoma cells. J Immunol. 150:1746.
8. Genot, E. M., Parker, P. J. and Cantrell, D. A. 1995. Analysis of the role of protein kinase C-α, ε, and ζ in T cell activation. J. Biol. Chem. 270:9833.
9. Keenan, C., Kelleher, D. and Long, A. 1995. Regulation of non-classical protein kinase C isoenzymes in a human T cell line. Eur. J. Immunol. 25:13.
10. Diaz-Meco, M. T., Berra, E., Municio, M. M., Sanz, L., Lozano, J. Dominguez,I., Diaz-Golpe,V., Lain de Lerra, M. T., Alcami, J., Paya, C. V., Arenzana-Seisdedos, F., Virelizier, J. and Moscat, J. A. 1993. A dominant negative mutant of protein kinase C ζ subspecies blocks NF-κB activation. Mol. Cell. Biol. 13:4770.
11. Strulovici, B., Daniel-Issakani, S., Baxter, G., Knopf, J., Sultzman, L., Cherwinski, H., Nestor, J., Webb, D. R. and Ransom, J. 1991. Distinct mechanisms of regulation of protein kinase C ε by hormones and phorbol diesters. J. Biol. Chem. 266:168.
12. Gomez, J., Pitton, C., Garcia, A., Martinez de Aragon, A., Silva, A. and Rebello, A. 1995. The ζ isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T cell line: evidence for an additional role of protein kinase C ε and β. Exp. Cell. Res. 218:105.
13. Gomez, J., Martinez de Aragon, A., Bonay, P., Pitton, C., Garcia, A., Silva, A., Fresno, M., Alvarez, F. and Rebello, A. 1995. Physical association and functional relationship between protein kinase C ζ and the actin cytoskeleton. Eur. J. Immunol. 25:2673.
14. Chakravarthy, B. R., Bussey, A., Whitfield, J. F., Sikorska, M., Williams, R. E. and Durkin, J. P. 1991. The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate. Anal. Biochem. 196:144.
15. Brooksbank, C. E. L., Hutchings, A., Butcher, G. W., Irvine, R. F. and Divencha, N. 1993. Monoclonal antibodies to phosphatidylinositol 4-phosphate 5-kinase: distribution and intracellular localization of the C isoform. Biochem. J. 291:77.
16. Bradford, M. W. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
17. Ways, D. K., Cook, P. P., Webster, C. and Parker, P. J. 1992. Effect of phorbol esters on protein kinase C-ζ. J. Biol. Chem. 267:4799.
18. Long, A., O'Connell, M., Liskamp, R. H. K. and Kelleher, D. 1993. Regulation of CD3 expression in a protein kinase C isozymedeficient T cell line. Immunology 80:654.
19. Kelleher, D., Murphy, A., Feighery, C. and Casey, E. B. 1995. Leukocyte function-associated antigen 1 (LFA-1) and CD44 are signaling molecules for cytoskeleton-dependent morphological changes in activated T cells. J. Leuk. Biol. 58:539.
20. Donnelly, S., Long, A., Hall, N., Murphy, A., Casey. E. B. and Kelleher, D. 1995. Role of protein kinase C in cellular activation for signaling through CD44 and LFA-1. Irish J. Med. Sci. 164:90.
21. Nanberg, E., Morris, C., Higgins, T., Vara, F. and Rozengurt, E. 1990. Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without calcium mobilization or inositol phosphate accumulation. J. Cell Physiol. 143:232.
22. Tremblay, Y. L.R., Jouishomme, H., Chakravarthy, B. and Durkin, J. P. 1994. Evidence that the activation of an inactive pool of membrane-associated protein kinase C is linked to the IL-2 dependent survival of T lymphocytes. J. Immunol. 153:1495.
23. Nishikawa, K., Yamamoto, S., Nagumo, H., Maruyama, K. and Kato, R. 1995 The presence of phorbol ester responsive and non-responsive forms of the zeta isozyme of protein kinase C in mouse epidermal cells. Cell Signal. 7:491.
24. Southern, C., Wilkinson, P. C., Thorp, K. M., Henderson, L. K., Nemec, M. and Matthews, N. 1995. Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations. Immunology 84:326.
25. Murti, G. K., Kaur, K. and Goorha, R. M. 1992. Protein kinase C associates with intermediate filaments and stress fibers. Exp. Cell. Res. 202:36.
26. Gregorio, C. C., Repasky, E. A., Fowler, V. M. and Black, J. D. 1994. Dynamic properties of ankyrin in T lymphocytes; colocalization with spectrin and protein kinase C β. J. Cell Biol. 125:345.
27. Lord, J. M., Johnson, G. D. and Owen, P. J. 1994. PKC-δ associates with vimentin in differentiated HL60 cells. J. Cell. Biochem. 18:86.
28. Omary, M. B., Baxter, G. T., Chou, C., Riopel, C. L., Lin, W. Y. and Strulovici, B. 1992. PKC ε related kinase associates with and phosphorylates cytokeratin 8 and 18. J. Cell Biol. 117:583.
29. Disatnik, M., Buraggi, G. and Mochly-Rosen, D. 1994. Localization of protein kinase C isozymes in cardiac myocytes. Exp. Cell Res. 210:287.
30. Rosen, A., Keenan, K. F., Thelen, M., Nairn, A. C. and Aderem, A. A. 1990. Activation of protein kinase C results in the displacement of its myristolated, alanine-rich substrate from punctate structures in macrophage filopodia. J. Exp. Med. 172:1211.
31. 1 rat pituitary cells. J. Biol. Chem. 233:15704.
32. Long, A. and Kelleher, D. 1993. Conventional protein kinase C isoforms are not required for cellular proliferation of a T cell lymphoma line. FEBS Lett. 333:243.