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Volumn 15, Issue 2, 1997, Pages 157-173

Raxofelast (IRFI 016): A new hydrophilic vitamin E-like antioxidant agent

Author keywords

Antioxidant; Free radicals; IRFI 016; Lipid peroxidation; Myocardial ischemia; Raxofelast

Indexed keywords

ALPHA TOCOPHEROL DERIVATIVE; ANTIOXIDANT; IRFI 005; RAXOFELAST; RAXOFLEST; SUPEROXIDE; UNCLASSIFIED DRUG;

EID: 0030768269     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.1997.tb00329.x     Document Type: Review
Times cited : (18)

References (40)
  • 1
    • 0023727653 scopus 로고
    • Cardioprotective actions of human superoxide dismutase in two reperfusion models of myocardial ischaemia in the rat
    • Aoki N, Bitterman H, Brenzinski ME, Lefer AM. Cardioprotective actions of human superoxide dismutase in two reperfusion models of myocardial ischaemia in the rat. Br J Pharmacol 1988;95:735-740.
    • (1988) Br J Pharmacol , vol.95 , pp. 735-740
    • Aoki, N.1    Bitterman, H.2    Brenzinski, M.E.3    Lefer, A.M.4
  • 2
    • 84958114079 scopus 로고
    • The reaction between thiobarbituric acid and the oxidation products of certain lipides
    • Bernheirn F, Bernheim MLC, Wilbur KM. The reaction between thiobarbituric acid and the oxidation products of certain lipides. J Biol Chem 1948;174:257-264.
    • (1948) J Biol Chem , vol.174 , pp. 257-264
    • Bernheirn, F.1    Bernheim, M.L.C.2    Wilbur, K.M.3
  • 3
    • 0026802254 scopus 로고
    • Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl)acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice
    • Bianco T, Centore R, Giannetti P, Scuri R. Compared kinetics of 2-(2,3-dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl)acetic acid (IRFI 016) and its active metabolite 2-(2,3-dihydro-5-hydroxy-4,6,7-trimethylbenzofuranyl)acetic acid (IRFI 005) in plasma and bronchial alveolar liquid in mice. Drugs Exp Clin Res 1992;18:93-97.
    • (1992) Drugs Exp Clin Res , vol.18 , pp. 93-97
    • Bianco, T.1    Centore, R.2    Giannetti, P.3    Scuri, R.4
  • 4
    • 0026039398 scopus 로고
    • Protective action of a new benzofuran derivative on lipid peroxidation and sulphydryl groups oxidation
    • Bindoli A, Rigobello MP, Musacchio E, Scuri R, Rizzoli V, Galzigna L. Protective action of a new benzofuran derivative on lipid peroxidation and sulphydryl groups oxidation. Pharmacol Res 1991;24:369-375.
    • (1991) Pharmacol Res , vol.24 , pp. 369-375
    • Bindoli, A.1    Rigobello, M.P.2    Musacchio, E.3    Scuri, R.4    Rizzoli, V.5    Galzigna, L.6
  • 6
    • 0022628331 scopus 로고
    • Role of free radicals in lung injury
    • Brigham KL. Role of free radicals in lung injury. Chest 1986;89:859-863.
    • (1986) Chest , vol.89 , pp. 859-863
    • Brigham, K.L.1
  • 7
    • 33845377128 scopus 로고
    • Autoxidation of biological molecules. Maximizing the antioxidant activity of phenols
    • Burton GW, Doba T, Gabe EJ, et al. Autoxidation of biological molecules. Maximizing the antioxidant activity of phenols. J Am Chem Soc 1985;107:7053-7065.
    • (1985) J Am Chem Soc , vol.107 , pp. 7053-7065
    • Burton, G.W.1    Doba, T.2    Gabe, E.J.3
  • 8
    • 0021066063 scopus 로고
    • Antioxidant activity of phenols related to vitamin E. Are there chain-breaking antioxidants better than α-tocopherol?
    • Burton GW, Hughes L, Ingold KU. Antioxidant activity of phenols related to vitamin E. Are there chain-breaking antioxidants better than α-tocopherol? J Am Chem Soc 1983;105:5950-5951.
    • (1983) J Am Chem Soc , vol.105 , pp. 5950-5951
    • Burton, G.W.1    Hughes, L.2    Ingold, K.U.3
  • 9
    • 0027731950 scopus 로고
    • A new antioxidant drug limits brain damage induced by transient cerebral ischaemia
    • Calapai G, Squadrito F, Rizzo A, et al. A new antioxidant drug limits brain damage induced by transient cerebral ischaemia. Drugs Exp Clin Res 1993;19:159-164.
    • (1993) Drugs Exp Clin Res , vol.19 , pp. 159-164
    • Calapai, G.1    Squadrito, F.2    Rizzo, A.3
  • 10
    • 9844256856 scopus 로고
    • Effetto protettivo dell'IRFI 016, un nuovo composto antiossidante, sul danno miocardico da ischemia e riperfusione nel ratto
    • Campo GM, Ioculano M, Avenoso A, Pollicino MA, Calandra S. Effetto protettivo dell'IRFI 016, un nuovo composto antiossidante, sul danno miocardico da ischemia e riperfusione nel ratto. Atti Acc Pelor Per 1991;29:177-194.
    • (1991) Atti Acc Pelor Per , vol.29 , pp. 177-194
    • Campo, G.M.1    Ioculano, M.2    Avenoso, A.3    Pollicino, M.A.4    Calandra, S.5
  • 11
    • 0026747923 scopus 로고
    • IRFI 016, a new radical scavenger, limits ischemic damage following coronary artery occlusion in rats
    • Campo GM, Squadrito F, Ioculano M, et al. IRFI 016, a new radical scavenger, limits ischemic damage following coronary artery occlusion in rats. Res Commun Chem Pathol Pharmacol 1992;76:287-303.
    • (1992) Res Commun Chem Pathol Pharmacol , vol.76 , pp. 287-303
    • Campo, G.M.1    Squadrito, F.2    Ioculano, M.3
  • 12
    • 0028157820 scopus 로고
    • Protective effects of IRFI016, a new antioxidant agent, in myocardial damage following coronary artery occlusion and reperfusion in the rat
    • Campo GM, Squadrito F, Ioculano M, et al. Protective effects of IRFI016, a new antioxidant agent, in myocardial damage following coronary artery occlusion and reperfusion in the rat. Pharmacology 1994; 48:157-166.
    • (1994) Pharmacology , vol.48 , pp. 157-166
    • Campo, G.M.1    Squadrito, F.2    Ioculano, M.3
  • 13
    • 0027184224 scopus 로고
    • Synthesis of novel 2-substituted-5-oxycoumarans via a direct route to 2,3-dihydro-5-hydroxy-2-benzofuranacetic acids
    • Ceccarelli S, De Vellis P, Scuri R, Zanarella S. Synthesis of novel 2-substituted-5-oxycoumarans via a direct route to 2,3-dihydro-5-hydroxy-2-benzofuranacetic acids. J Heterocycl Chem 1993;30:679-690.
    • (1993) J Heterocycl Chem , vol.30 , pp. 679-690
    • Ceccarelli, S.1    De Vellis, P.2    Scuri, R.3    Zanarella, S.4
  • 14
    • 0002830564 scopus 로고
    • Pharmacokinetic profile of raxofelast, a novel antioxidant agent chemically related to alpha-tocopherol
    • Centore R, Bianco T, Ceccarelli S, Dorigotti L. Pharmacokinetic profile of raxofelast, a novel antioxidant agent chemically related to alpha-tocopherol. Pharmacol Res (Suppl.) 1995;31:38.
    • (1995) Pharmacol Res , vol.31 , Issue.SUPPL. , pp. 38
    • Centore, R.1    Bianco, T.2    Ceccarelli, S.3    Dorigotti, L.4
  • 15
    • 0019264856 scopus 로고
    • An approach to free radicals in medicine and biology
    • Del Maestro RF. An approach to free radicals in medicine and biology. Acta Physiol Scand 1980;492:153-168.
    • (1980) Acta Physiol Scand , vol.492 , pp. 153-168
    • Del Maestro, R.F.1
  • 17
    • 85047679428 scopus 로고
    • Histochemical demonstration of endothelial Superoxide and hydrogen peroxide generation in ischaemic and reoxygenated rat tissue
    • Fabbs CF, Cregor MD, Badylak SF. Histochemical demonstration of endothelial Superoxide and hydrogen peroxide generation in ischaemic and reoxygenated rat tissue. Cardiovasc Res 1992;26:593-602.
    • (1992) Cardiovasc Res , vol.26 , pp. 593-602
    • Fabbs, C.F.1    Cregor, M.D.2    Badylak, S.F.3
  • 18
    • 0025314685 scopus 로고
    • Role of oxygen free radicals in carcinogenesis and brain ischemia
    • Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 1990;4:2587-2597.
    • (1990) FASEB J , vol.4 , pp. 2587-2597
    • Floyd, R.A.1
  • 19
    • 0025996756 scopus 로고
    • U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia
    • Hall ED, Braughler JM, Yonkers PA, et al. U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J Pharmacol Exp Ther 1991;258:688-694.
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 688-694
    • Hall, E.D.1    Braughler, J.M.2    Yonkers, P.A.3
  • 20
    • 0025069762 scopus 로고
    • How to characterize a biological antioxidant
    • Halliwell B. How to characterize a biological antioxidant. Free Rad Biol Med 1990;9:1-32.
    • (1990) Free Rad Biol Med , vol.9 , pp. 1-32
    • Halliwell, B.1
  • 22
    • 0029064010 scopus 로고
    • Chemiluminescent measurement of increased free radicals formation after ischemia/reperfusion in liver
    • Nunes FA, Kumar C, Change B, Brass CA. Chemiluminescent measurement of increased free radicals formation after ischemia/reperfusion in liver. Dig Dis Sci 1995;40:1045-1053.
    • (1995) Dig Dis Sci , vol.40 , pp. 1045-1053
    • Nunes, F.A.1    Kumar, C.2    Change, B.3    Brass, C.A.4
  • 23
    • 0021343227 scopus 로고
    • Canine myocardial reperfusion injury: Its reduction by the combined administration of Superoxide dismutase and catalase
    • Jolly S, Kane WJ, Baile MB, Abrams GD, Lucchesi BR. Canine myocardial reperfusion injury: its reduction by the combined administration of Superoxide dismutase and catalase. Circ Res 1984;54:277-285.
    • (1984) Circ Res , vol.54 , pp. 277-285
    • Jolly, S.1    Kane, W.J.2    Baile, M.B.3    Abrams, G.D.4    Lucchesi, B.R.5
  • 25
    • 0025772850 scopus 로고
    • Dihydro-hydroxy-trimethyl-benzofuranyl acetic acid inhibits lipid peroxidation and lysosomal enzyme release in bronchial epithelial cells and macrophages
    • Mattoli S, Mezzetti M, Allegra L, Braga PC. Dihydro-hydroxy-trimethyl-benzofuranyl acetic acid inhibits lipid peroxidation and lysosomal enzyme release in bronchial epithelial cells and macrophages. Ital J Chest Dis 1991;45:78-80.
    • (1991) Ital J Chest Dis , vol.45 , pp. 78-80
    • Mattoli, S.1    Mezzetti, M.2    Allegra, L.3    Braga, P.C.4
  • 26
    • 0020612531 scopus 로고
    • The superoxide free radical: Its biochemistry and pathophysiology
    • McCord JM. The superoxide free radical: Its biochemistry and pathophysiology. Surgery 1983;94:412-414.
    • (1983) Surgery , vol.94 , pp. 412-414
    • McCord, J.M.1
  • 27
    • 0026519266 scopus 로고
    • Selenium in renal failure patients
    • Milly K, Wit L, Diskin C, Tulley R. Selenium in renal failure patients. Nephron 1992;61:139-144.
    • (1992) Nephron , vol.61 , pp. 139-144
    • Milly, K.1    Wit, L.2    Diskin, C.3    Tulley, R.4
  • 28
    • 0022636393 scopus 로고
    • Effects of supplementing hypothermie crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol or deferoxamine on functional recovery of globally ischaemic and reperfused isolated hearts
    • Myers CL, Weiss SJ, Kirsh MM, Shepard BM, Shlafer M. Effects of supplementing hypothermie crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol or deferoxamine on functional recovery of globally ischaemic and reperfused isolated hearts. J Thorac Cardiovasc Surg 1986;91:281-289.
    • (1986) J Thorac Cardiovasc Surg , vol.91 , pp. 281-289
    • Myers, C.L.1    Weiss, S.J.2    Kirsh, M.M.3    Shepard, B.M.4    Shlafer, M.5
  • 29
    • 0031043577 scopus 로고    scopus 로고
    • 5-Aminocoumarans: Dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia
    • Ohkawa S, Fukatsu K, Miki S, et al. 5-Aminocoumarans: Dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia. J Med Chem 1997;40: 559-573.
    • (1997) J Med Chem , vol.40 , pp. 559-573
    • Ohkawa, S.1    Fukatsu, K.2    Miki, S.3
  • 30
    • 0026069169 scopus 로고
    • Effect of a cardioselective α-tocopherol analogue on reperfusion injury in rats induced by myocardial ischemia
    • Petty MA, Dow J, Grisar JM, De Jong W. Effect of a cardioselective α-tocopherol analogue on reperfusion injury in rats induced by myocardial ischemia. Eur J Pharmacol 1991;192:383-388.
    • (1991) Eur J Pharmacol , vol.192 , pp. 383-388
    • Petty, M.A.1    Dow, J.2    Grisar, J.M.3    De Jong, W.4
  • 31
    • 0027315339 scopus 로고
    • Vitamin E consumption and the risk of coronary heart disease in men
    • Rimm EB, Stampfer MJ, Ascherio A. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-1456.
    • (1993) N Engl J Med , vol.328 , pp. 1450-1456
    • Rimm, E.B.1    Stampfer, M.J.2    Ascherio, A.3
  • 32
    • 0025560949 scopus 로고
    • 2-(2,3-Dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016): A new antioxidant mucoactive drug
    • Scuri R, Giannetti P, Paesano A. 2-(2,3-Dihydro-5-acetoxy-4,6,7-trimethylbenzofuranyl) acetic acid (IRFI 016): A new antioxidant mucoactive drug. Drugs Exp Clin Res 1990;16:649-656.
    • (1990) Drugs Exp Clin Res , vol.16 , pp. 649-656
    • Scuri, R.1    Giannetti, P.2    Paesano, A.3
  • 33
    • 0027154706 scopus 로고
    • Vitamin E consumption and the risk of coronary heart disease in women
    • Stampfer MJ, Hennekens CH, Manson JE. Vitamin E consumption and the risk of coronary heart disease in women. N Engl J Med 1993;328:1444-1449.
    • (1993) N Engl J Med , vol.328 , pp. 1444-1449
    • Stampfer, M.J.1    Hennekens, C.H.2    Manson, J.E.3
  • 34
    • 0024513261 scopus 로고
    • Oxidation and reaction of Trolox C, a tocopherol analogue, in aqueous solution: A pulse-radiolysis study
    • Thomas MJ, Bielski BHJ. Oxidation and reaction of Trolox C, a tocopherol analogue, in aqueous solution: A pulse-radiolysis study. J Am Chem Soc 1989;111:3315-3319.
    • (1989) J Am Chem Soc , vol.111 , pp. 3315-3319
    • Thomas, M.J.1    Bielski, B.H.J.2
  • 35
    • 38249011960 scopus 로고
    • Pharmacokinetics of IRFI 016 and IRFI 005 in rats
    • Urso R, Moltoni L, Billarelli C, Segre G. Pharmacokinetics of IRFI 016 and IRFI 005 in rats. Pharmacol Res (Suppl. 1) 1992;26:265.
    • (1992) Pharmacol Res , vol.26 , Issue.1 SUPPL. , pp. 265
    • Urso, R.1    Moltoni, L.2    Billarelli, C.3    Segre, G.4
  • 36
    • 0023832595 scopus 로고
    • Decrease in lipid peroxidation measured by breath pentane output in normals after oral supplementation with vitamin E
    • Van Gossum A, Kurian R, Whitwell J, Jeejeebhoy KN. Decrease in lipid peroxidation measured by breath pentane output in normals after oral supplementation with vitamin E. Clin Nutr 1988;7:53-57.
    • (1988) Clin Nutr , vol.7 , pp. 53-57
    • Van Gossum, A.1    Kurian, R.2    Whitwell, J.3    Jeejeebhoy, K.N.4
  • 37
    • 9844245507 scopus 로고    scopus 로고
    • Characterization of in vitro redox interactions of the antioxidant raxofelast and its metabolites with red blood cells
    • To be presented Sept 23-26, Turin, Italy
    • Viglianti B, Ceccareilli S, Dorigotti L. Characterization of in vitro redox interactions of the antioxidant raxofelast and its metabolites with red blood cells. To be presented at the First Italian-Swiss Meeting on Medicinal Chemistry, Sept 23-26, 1997, Turin, Italy.
    • (1997) First Italian-Swiss Meeting on Medicinal Chemistry
    • Viglianti, B.1    Ceccareilli, S.2    Dorigotti, L.3
  • 38
    • 0026534422 scopus 로고
    • Role of reactive oxygen species in intestinal diseases
    • Vliet AVD, Bast A. Role of reactive oxygen species in intestinal diseases. Free Rad Biol Med 1992;12: 499-513.
    • (1992) Free Rad Biol Med , vol.12 , pp. 499-513
    • Vliet, A.V.D.1    Bast, A.2
  • 39
    • 0024602827 scopus 로고
    • Tissue destruction by neutrophils
    • Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989;320:365-376.
    • (1989) N Engl J Med , vol.320 , pp. 365-376
    • Weiss, S.J.1
  • 40
    • 0023867107 scopus 로고
    • Measurement of superoxide-derived free radicals in the reperfused heart
    • Zweier JL. Measurement of superoxide-derived free radicals in the reperfused heart. J Biol Chem 1988; 263:1353-1357.
    • (1988) J Biol Chem , vol.263 , pp. 1353-1357
    • Zweier, J.L.1


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