A repeated-dose dermal toxicity study of hydrophobically modified hydroxypropyl methylcellulose in rats

Journal of Toxicological Sciences

Volumn 22, Issue 3, 1997, Pages 255-280

  Obara, Sakae ^a   Muto, Hiroaki ^a   Ichikawa, Naoto ^b   Tanaka, Osamu ^b   Otsuka, Michio ^b   Kawanabe, Mikiko ^b   Ishii, Hiroyuki ^b   Niikura, Yoshiyuki ^b   Komatsu, Masahiko ^b  

^a SHIN ETSU CHEMICAL CO LTD   (Japan)

^b Bio Med Res Laboratories Co   (Japan)

Author keywords

Dermal; Hydrophobically modified hydroxypropyl methyl cellulose; Rat; Repeated administration

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEMATOLOGY; HISTOPATHOLOGY; MALE; NONHUMAN; OPHTHALMOLOGY; ORGAN WEIGHT; RAT; SKIN TOXICITY; TOPICAL DRUG ADMINISTRATION; URINALYSIS;

ANIMALIA;

EID: 0030768169     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.3_255     Document Type: Article

References (5)

1. Cosmetic Toiletry and Fragrance Association (1986): Final report on the safety assessment of hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, hydroxypropyl methylcellulose, and cellulose gum. J. Am. Coll. Toxicol., 5, 1-59.
2. Obara, S., Muto, H., Kokubo, H., Ichikawa, N., Kawanabe, M., and Tanaka, O. (1992a): Studies on single-dose toxicity of hydrophobically modified hydroxypropyl methylcellulose in rats. J. Toxicol. Sci., 17, 13-18.
3. Obara, S., Muto, H., Kokubo, H., Ichikawa, N., Kawanabe, M., and Tanaka, O. (1992b): Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits. J. Toxicol. Sci., 17, 21-29.
4. Saito, I., Ikeda, K., Takehara, M., Takagishi, Y., Obara, S., and Muto, H. (1992a): Synthesis of hydrophobically modified hydroxypropyl methylcellulose and its basic properties as a viscous agent. Yakuzaigaku, 52, 272-279.
5. Saito, I., Ikeda, K., Takehara, M., Takagishi, Y., Obara, S., and Muto, H. (1992b): Preparation of gel with hydrophobically modified hydroxypropyl methylcellulose and its evaluation. Yakuzaigaku, 52, 280-287.