메뉴 건너뛰기




Volumn 86, Issue 37, 1997, Pages 1418-1423

Special aspects of antiepileptic drug therapy in the elderly;Besonderheiten der Pharmakotherapie von Epilepsien im hoheren Lebensalter

Author keywords

antiepileptic drugs; epilepsy in the elderly; pharmacotherapy

Indexed keywords

CARBAMAZEPINE; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; VALPROIC ACID; VIGABATRIN;

EID: 0030767153     PISSN: 16618157     EISSN: 16618165     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (60)
  • 1
    • 0025311367 scopus 로고
    • Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations
    • Abernethy D.R., Azarnoff D.L.: Pharmacokinetic investigations in elderly patients. Clinical and ethical considerations. Clin. Pharmacokinet. 19, 89-93, 1990.
    • (1990) Clin. Pharmacokinet. , vol.19 , pp. 89-93
    • Abernethy, D.R.1    Azarnoff, D.L.2
  • 2
    • 0019847451 scopus 로고
    • Disposition of antipyrine and phenytoin correlated with age and liver volume in man
    • Bac, B., Hansen J.M., Kampmann J.P., Rasmussen S. N., Skovsted L. : Disposition of antipyrine and phenytoin correlated with age and liver volume in man. Clin. Pharmacokin. 6, 389-396, 1981.
    • (1981) Clin. Pharmacokin. , vol.6 , pp. 389-396
    • Bac, B.1    Hansen, J.M.2    Kampmann, J.P.3    Rasmussen, S.N.4    Skovsted, L.5
  • 3
    • 0020085741 scopus 로고
    • Age and phenytoin kinetics in adult epileptics
    • Bauer L.A, Blouin R.A.: Age and phenytoin kinetics in adult epileptics. Clin. Pharmacol. Ther. 31, 301-304, 1982.
    • (1982) Clin. Pharmacol. Ther. , vol.31 , pp. 301-304
    • Bauer, L.A.1    Blouin, R.A.2
  • 4
    • 0021806783 scopus 로고
    • Valproic acid clearance: Unbound fraction and diurnal variation in young and elderly adults
    • Bauer L.A., Davis R., Wilensky A., Raisys V., Levy R.H.: Valproic acid clearance: Unbound fraction and diurnal variation in young and elderly adults. Clin. Pharmacol. Ther. 37, 697-699, 1985.
    • (1985) Clin. Pharmacol. Ther. , vol.37 , pp. 697-699
    • Bauer, L.A.1    Davis, R.2    Wilensky, A.3    Raisys, V.4    Levy, R.H.5
  • 5
    • 8244222353 scopus 로고
    • The aging liver
    • Abrams, W.B., M.H. Beers, R. Berkow (eds.): Merck & Co., Whitehouse Station, N.J.
    • Bay M.K.: The aging liver. In: Abrams, W.B., M.H. Beers, R. Berkow (eds.): The Merck Manual of Geriatrics, 2nd Edition. Merck & Co., Whitehouse Station, N.J., 696-699, 1995.
    • (1995) The Merck Manual of Geriatrics, 2nd Edition , pp. 696-699
    • Bay, M.K.1
  • 6
    • 0024582463 scopus 로고
    • Risk factor in geriatric drug prescribing, a practical guide to avoiding problems
    • Beers MH, Ouslander J.G.: Risk factor in geriatric drug prescribing, A practical guide to avoiding problems. Drugs 37, 105-112, 1989.
    • (1989) Drugs , vol.37 , pp. 105-112
    • Beers, M.H.1    Ouslander, J.G.2
  • 7
    • 12644294749 scopus 로고
    • Drug-drug, interactions and aging
    • Jarvik, L.F., D.J.Greenblatt, D.Harman (eds.). Raven Press, New York
    • Blaschke T.F., Cohen S.N., Tatro D.S., Rubin P. C.: Drug-drug, interactions and aging. In: Jarvik, L.F., D.J.Greenblatt, D.Harman (eds.). Clinical Pharmacology and the Aged Patient (Aging, Volume 16). Raven Press, New York, 11-26, 1981.
    • (1981) Clinical Pharmacology and the Aged Patient Aging , vol.16 , pp. 11-26
    • Blaschke, T.F.1    Cohen, S.N.2    Tatro, D.S.3    Rubin, P.C.4
  • 8
    • 0000276697 scopus 로고    scopus 로고
    • Effect of subject age on the single dose pharmacokinetics of orally administered gabapentin (CI-945)
    • Boyd R.A., Bockbrader H.N., Türck D., Sedman A.J., Posvar E.L., Chang T.: Effect of subject age on the single dose pharmacokinetics of orally administered gabapentin (CI-945) (abstract). Pharm. Res. 7, Suppl. 9, S-215.
    • Pharm. Res. , vol.7 , Issue.9 SUPPL.
    • Boyd, R.A.1    Bockbrader, H.N.2    Türck, D.3    Sedman, A.J.4    Posvar, E.L.5    Chang, T.6
  • 10
    • 0028997696 scopus 로고
    • Anticonvulsant therapy in the elderly - A need for placebo controlled trials
    • Cameron H., Macphee G.J.A.: Anticonvulsant therapy in the elderly - A need for placebo controlled trials. Epilepsy Res. 21, 149-157, 1995.
    • (1995) Epilepsy Res. , vol.21 , pp. 149-157
    • Cameron, H.1    Macphee, G.J.A.2
  • 11
    • 0028472887 scopus 로고
    • Antiepileptic drugs in the elderly: Pharmaco-epidemiology and pharmacokinetics
    • Cloyd J.C., Lackner T.E., Leppik I.E.: Antiepileptic drugs in the elderly: pharmaco-epidemiology and pharmacokinetics. Arch. Family Med. 3, 589-598, 1994.
    • (1994) Arch. Family Med. , vol.3 , pp. 589-598
    • Cloyd, J.C.1    Lackner, T.E.2    Leppik, I.E.3
  • 12
    • 0028330545 scopus 로고
    • Impact of valproate and phenytoin on cognitive function in elderly patients: Results of a single-blind randomized comparative study
    • Craig I., Tallis R.: Impact of valproate and phenytoin on cognitive function in elderly patients: results of a single-blind randomized comparative study. Epilepsia 35, 381-390, 1994.
    • (1994) Epilepsia , vol.35 , pp. 381-390
    • Craig, I.1    Tallis, R.2
  • 13
    • 0038061358 scopus 로고
    • Clinical Pharmacology
    • Abrams, W.B., M.H. Beers, R. Berkow (eds.): Merck & Co., Whitehouse Station. N. J.
    • Cusack B.J., Vestal R.E.: Clinical Pharmacology. In: Abrams, W.B., M.H. Beers, R. Berkow (eds.): The Merck Manual of Geriatrics, 2nd Edition. Merck & Co., Whitehouse Station. N. J., 255-276, 1995.
    • (1995) The Merck Manual of Geriatrics, 2nd Edition , pp. 255-276
    • Cusack, B.J.1    Vestal, R.E.2
  • 14
    • 0024447750 scopus 로고
    • Clinical pharmacokinetic considerations in the elderly. An update
    • Dawling S., Crome P.: Clinical pharmacokinetic considerations in the elderly. An update. Clin. Pharmacokinet. 17, 236-263, 1989.
    • (1989) Clin. Pharmacokinet. , vol.17 , pp. 236-263
    • Dawling, S.1    Crome, P.2
  • 15
  • 16
    • 0027253819 scopus 로고
    • Seizure disorders of aging; differential diagnosis and patient management
    • Drury I., Beydoun A.: Seizure disorders of aging; differential diagnosis and patient management. Geriatrics, 48, 52-58, 1993.
    • (1993) Geriatrics , vol.48 , pp. 52-58
    • Drury, I.1    Beydoun, A.2
  • 18
  • 20
    • 0017848929 scopus 로고
    • The effects of dose, age, and sex on the serum levels of phenobarbital and diphenylhydantoin in epileptic patients
    • Furlanut M., Benetello P., Testa G., Da Ranch A.: The effects of dose, age, and sex on the serum levels of phenobarbital and diphenylhydantoin in epileptic patients. Pharmacol. Res. Comm. 10, 85-89, 1978.
    • (1978) Pharmacol. Res. Comm. , vol.10 , pp. 85-89
    • Furlanut, M.1    Benetello, P.2    Testa, G.3    Da Ranch, A.4
  • 21
    • 0018415172 scopus 로고
    • Reduced serum albumin concentration in the elderly: A report from the Boston collaborative drug surveillance program
    • Greenblatt D.J.: Reduced serum albumin concentration in the elderly: A report from the Boston collaborative drug surveillance program. J. Amer. Geriatr. Soc. 27, 20-22, 1979.
    • (1979) J. Amer. Geriatr. Soc. , vol.27 , pp. 20-22
    • Greenblatt, D.J.1
  • 22
    • 2042539561 scopus 로고
    • Pharmacokinetics in old age: Principles and problems of assessment
    • Jarvik, L.F., D.J.Greenblatt, D.Harman (eds.). Raven Press, New York
    • Greenblatt D.J., Shader R.I.: Pharmacokinetics in old age: Principles and problems of assessment. In: Jarvik, L.F., D.J.Greenblatt, D.Harman (eds.). Clinical Pharmacology and the Aged Patient (Aging, Vol. 16). Raven Press, New York, 27-46, 1981.
    • (1981) Clinical Pharmacology and the Aged Patient Aging , vol.16 , pp. 27-46
    • Greenblatt, D.J.1    Shader, R.I.2
  • 26
    • 0028855054 scopus 로고
    • Seizure control after chronic pharmacotherapy in epileptic disorders beginning after 40 years of age
    • Hasegawa H., Kanner A.M.: Seizure control after chronic pharmacotherapy in epileptic disorders beginning after 40 years of age. Clin. Neuropharmacol. 18, 13-22, 1995.
    • (1995) Clin. Neuropharmacol. , vol.18 , pp. 13-22
    • Hasegawa, H.1    Kanner, A.M.2
  • 27
    • 0026442417 scopus 로고
    • Seizure disorders: The changes with age
    • Hauser W. A.: Seizure disorders: the changes with age. Epilepsia 33, Suppl. 4, S6-S14, 1992.
    • (1992) Epilepsia , vol.33 , Issue.4 SUPPL.
    • Hauser, W.A.1
  • 28
    • 0016432697 scopus 로고
    • Changes in drug metabolism with increasing age: 2. Phenytoin clearance and protein binding
    • Hayes M.J., Longman M.J.S., Short A.H.: Changes in drug metabolism with increasing age: 2. Phenytoin clearance and protein binding. Br. J. Clin. Pharmacol. 2, 73-79, 1975.
    • (1975) Br. J. Clin. Pharmacol. , vol.2 , pp. 73-79
    • Hayes, M.J.1    Longman, M.J.S.2    Short, A.H.3
  • 30
    • 0016721610 scopus 로고
    • Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients
    • Houghton G.W., Richens A., Leighton M.: Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients. Br. J. Clin. Pharmacol. 2, 251-256, 1975.
    • (1975) Br. J. Clin. Pharmacol. , vol.2 , pp. 251-256
    • Houghton, G.W.1    Richens, A.2    Leighton, M.3
  • 32
    • 0017657655 scopus 로고
    • Phenytoin dosage in the elderly
    • Lambie D.C., Caird F.I.: Phenytoin dosage in the elderly. Age and Aging 6, 133-137, 1977.
    • (1977) Age and Aging , vol.6 , pp. 133-137
    • Lambie, D.C.1    Caird, F.I.2
  • 33
    • 0023036214 scopus 로고
    • The elderly and drug interactions
    • Lamy P.P.: The elderly and drug interactions. J. Amer. Geriatr. Soc 34, 586-592, 1986.
    • (1986) J. Amer. Geriatr. Soc , vol.34 , pp. 586-592
    • Lamy, P.P.1
  • 34
    • 0026912808 scopus 로고
    • Changes in renal function with aging. Implications for treatment
    • Lindeman R.D.: Changes in renal function with aging. Implications for treatment. Drugs & Aging 2, 423-431, 1992.
    • (1992) Drugs & Aging , vol.2 , pp. 423-431
    • Lindeman, R.D.1
  • 38
    • 0026794763 scopus 로고
    • A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults
    • Mattson K.H., Cramer J.A., Collins J.F. and The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. N. Engl. J. Med. 327, 765-771, 1992.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 765-771
    • Mattson, K.H.1    Cramer, J.A.2    Collins, J.F.3
  • 39
    • 0020052620 scopus 로고
    • Mis-diagnosis of stroke
    • Norris J.W., Hachinski V.C.: Mis-diagnosis of stroke. Lancet 1, 328-331, 1982.
    • (1982) Lancet , vol.1 , pp. 328-331
    • Norris, J.W.1    Hachinski, V.C.2
  • 40
    • 0013402901 scopus 로고
    • Pharmacokinetics of anticonvulsant drugs in the elderly
    • Wyllie, E. (ed.). Lea & Febiger, Philadelphia
    • Parker B.M., Vestal R.E.: Pharmacokinetics of anticonvulsant drugs in the elderly. In: Wyllie, E. (ed.). The Treatment of Epilepsy: Principles and Practice. Lea & Febiger, Philadelphia, 769-774, 1993.
    • (1993) The Treatment of Epilepsy: Principles and Practice , pp. 769-774
    • Parker, B.M.1    Vestal, R.E.2
  • 44
    • 0025835171 scopus 로고
    • Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers
    • Posner J., Holdich T., Crome P.: Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers. J. Pharm. Med. 1, 121-128, 1991.
    • (1991) J. Pharm. Med. , vol.1 , pp. 121-128
    • Posner, J.1    Holdich, T.2    Crome, P.3
  • 45
    • 0015244465 scopus 로고
    • Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function
    • Reidenberg M.M., Odar-Cederlöf M.I., von Bahr C., Borgå O., Sjöqvist F.: Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function. New Engl. J. Med. 285, 264-267, 1971.
    • (1971) New Engl. J. Med. , vol.285 , pp. 264-267
    • Reidenberg, M.M.1    Odar-Cederlöf, M.I.2    Von Bahr, C.3    Borgå, O.4    Sjöqvist, F.5
  • 47
    • 12644305570 scopus 로고
    • Aging, renal function, and response to drugs
    • L. F. Jarvik, D.J.Greenblatt, D.Harman (eds.). Raven Press, New York
    • Rowe J. W.: Aging, renal function, and response to drugs. In: L. F. Jarvik, D.J.Greenblatt, D.Harman (eds.). Clinical Pharmacology and the Aged Patient (Aging, Vol. 16). Raven Press, New York, 115-130, 1981.
    • (1981) Clinical Pharmacology and the Aged Patient Aging , vol.16 , pp. 115-130
    • Rowe, J.W.1
  • 48
    • 12644273492 scopus 로고
    • Seizures and epilepsy in the elderly
    • Pedley, T. A., Meldrum, B. S. (eds.). Churchill Livingstone, Edinburgh
    • Scheuer M.L.: Seizures and epilepsy in the elderly. In: Pedley, T. A., Meldrum, B. S. (eds.). Recent Advances in Epilepsy, Number Six. Churchill Livingstone, Edinburgh, 247-270, 1995.
    • (1995) Recent Advances in Epilepsy, Number Six , pp. 247-270
    • Scheuer, M.L.1
  • 49
    • 0027383360 scopus 로고
    • Seizures and epilepsy in the elderly
    • Scheuer M.L., Cohen J.: Seizures and epilepsy in the elderly. Neurol. Clinics 4, 787-804, 1993.
    • (1993) Neurol. Clinics , vol.4 , pp. 787-804
    • Scheuer, M.L.1    Cohen, J.2
  • 50
    • 0346479716 scopus 로고
    • Der Einfluss von Alter und Geschlecht auf die Plasmakonzentration von Phenytoin, Phenobarbital und Carbamazepin
    • O. Hallen, J. G. Meyer-Wahl, J. Braun (Hrsg.). Spät- und Residual-Epilepsien Nebenwirkungen von Antikonvulsiva, Einhorn-Presse Verlag, Reinbek
    • Schmidt D., Cornaggia D., Janz D.: Der Einfluss von Alter und Geschlecht auf die Plasmakonzentration von Phenytoin, Phenobarbital und Carbamazepin. In: O. Hallen, J. G. Meyer-Wahl, J. Braun (Hrsg.). Epilepsie 82. Spät- und Residual-Epilepsien Nebenwirkungen von Antikonvulsiva, Einhorn-Presse Verlag, Reinbek, 242-247, 1984.
    • (1984) Epilepsie 82 , pp. 242-247
    • Schmidt, D.1    Cornaggia, D.2    Janz, D.3
  • 51
    • 8544266079 scopus 로고
    • Altersepilepsie unter besonderer Berücksichtigung der Therapie
    • W. Fröscher (Hrsg.). Ueberreuter Wissenschaft, Wien
    • Schumm F.: Altersepilepsie unter besonderer Berücksichtigung der Therapie. In: W. Fröscher (Hrsg.). Aspekte der Epilepsie-Therapie, Ueberreuter Wissenschaft, Wien, 27-36, 1989.
    • (1989) Aspekte der Epilepsie-Therapie , pp. 27-36
    • Schumm, F.1
  • 52
    • 0002389317 scopus 로고    scopus 로고
    • Treatment of epilepsy in the elderly patient
    • S. Shorvon, F.Dreifuss, D.Fish, D. Thomas (eds.). Blackwell Science, London
    • Tallis R.: Treatment of epilepsy in the elderly patient. In: S. Shorvon, F.Dreifuss, D.Fish, D. Thomas (eds.). The Treatment of Epilepsy, Blackwell Science, London, 227-237, 1996.
    • (1996) The Treatment of Epilepsy , pp. 227-237
    • Tallis, R.1
  • 53
    • 0038608486 scopus 로고
    • Multicentre trial of valproate and phenytoin in elderly patients with newly diagnosed epilepsy
    • Tallis R., Easter D., Craig I.: Multicentre trial of valproate and phenytoin in elderly patients with newly diagnosed epilepsy (abstract). Age & Aging 23, Suppl. 2, P5, 1994.
    • (1994) Age & Aging , vol.23 , Issue.2 SUPPL.
    • Tallis, R.1    Easter, D.2    Craig, I.3
  • 54
    • 0016231322 scopus 로고
    • Zur Pharmakokinetik von Phenobarbital bei Erwachsenen und Greisen
    • Traeger A., Kiesewetter R., Kunze M.: Zur Pharmakokinetik von Phenobarbital bei Erwachsenen und Greisen. Dtsch. Ges.-wesen, 29, 1040-1042, 1974.
    • (1974) Dtsch. Ges.-wesen , vol.29 , pp. 1040-1042
    • Traeger, A.1    Kiesewetter, R.2    Kunze, M.3
  • 55
    • 0141557186 scopus 로고    scopus 로고
    • Status epilepticus in the elderly: Nosology and therapy
    • Rowan, A.J., Ramsay, R.E. (eds.): Butterworth-Heinemann, Boston, Oxford
    • Treiman D.M., Meyers P.D., Walton N.Y.: Status epilepticus in the elderly: nosology and therapy. In: Rowan, A.J., Ramsay, R.E. (eds.): Seizures and Epilepsy in the Elderly. Butterworth-Heinemann, Boston, Oxford, 207-215, 1997.
    • (1997) Seizures and Epilepsy in the Elderly , pp. 207-215
    • Treiman, D.M.1    Meyers, P.D.2    Walton, N.Y.3
  • 58
    • 0021200499 scopus 로고
    • Effect of age and sex on the plasma binding of acidic and basic drugs
    • Verbeeck R.K., Cardinal J.A., Wallace S.M.: Effect of age and sex on the plasma binding of acidic and basic drugs. Eur. J. Clin. Pharmacol. 27, 91-97, 1984.
    • (1984) Eur. J. Clin. Pharmacol. , vol.27 , pp. 91-97
    • Verbeeck, R.K.1    Cardinal, J.A.2    Wallace, S.M.3
  • 59
    • 0028801338 scopus 로고
    • The effect of age on pharmacokinetics of antiepileptic drugs
    • Willmore L.J.: The effect of age on pharmacokinetics of antiepileptic drugs. Epilepsia 36, 14-21, 1995.
    • (1995) Epilepsia , vol.36 , pp. 14-21
    • Willmore, L.J.1
  • 60
    • 0000345248 scopus 로고
    • Use of antiepileptic drugs in children and the elderly (general principles)
    • Levy R.H., Mattson R.H., Meldrum B.S. (eds.). Raven Press, New York
    • Willmore L.J., Dulac O.: Use of antiepileptic drugs in children and the elderly (general principles). In: Levy R.H., Mattson R.H., Meldrum B.S. (eds.). Antiepileptic Drugs, fourth edition. Raven Press, New York, 231-242, 1995.
    • (1995) Antiepileptic Drugs, Fourth Edition , pp. 231-242
    • Willmore, L.J.1    Dulac, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.