Skeletal involvement in female acromegalic subjects: The effects of growth hormone excess in amenorrheal and menstruating patients

Journal of Bone and Mineral Research

Volumn 12, Issue 10, 1997, Pages 1729-1736

  Scillitani, Alfredo ^a   Chiodini, Iacopo ^a   Carnevale, Vincenzo ^a   Giannatempo, Giuseppe M ^a   Frusciante, Vincenzo ^a   Villella, Massimo ^a   Pileri, Mauro ^a   Guglielmi, Giuseppe ^a   Di Giorgio, Anna ^a   Modoni, Sergio ^a   Fusilli, Saverio ^a   Di Cerbo, Alfredo ^a   Liuzzi, Antonio ^a  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM ION; COLLAGEN PEPTIDE; CREATININE; DEOXYPYRIDINOLINE; PYRIDINOLINE; UNCLASSIFIED DRUG;

ACROMEGALY; ADULT; AGED; AMENORRHEA; ARTICLE; BONE DENSITY; BONE MINERALIZATION; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GROWTH HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; MENSTRUATION; QUANTITATIVE DIAGNOSIS; SCORING SYSTEM;

ACROMEGALY; ADULT; AGED; ALKALINE PHOSPHATASE; AMENORRHEA; AMINO ACIDS; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BONE DENSITY; BONE DEVELOPMENT; CALCIUM; CREATININE; ESTROGENS; FEMALE; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MENSTRUATION; MIDDLE AGED; OSTEOCALCIN; PEPTIDE FRAGMENTS; PROCOLLAGEN;

EID: 0030766765     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.10.1729     Document Type: Article

References (45)

1. Inzucchi SE, Robbins RJ 1994 Effects of growth hormone on human bone biology. J Clin Endocrinol Metab 79:691-694.
2. Raisz LG 1988 Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med 318:818-828.
3. Canalis E 1993 Sistemic and local factors and the mainteinance of bone quality. Calcif Tissue Int 53: (Suppl 1):S90-S93.
4. Stracke H, Schultz A, Moeller D, Rossol S, Schaltz H 1984 Effect of GH on osteoblasts and demonstration of somatomedin CAGF-I in bone organ culture. Acta Endocrinol (Copenh) 107:16-24.
5. Maor G, Hochberg Z, Mark K, Heinegard D, Silbermann M 1989 Human growth hormone enhances chondrogenesis and osteogenesis in a tissue culture system of chondro-progenitor cells. Endocrinology 125:1239-1245.
6. Slootweg MC, van Buul-Offers SC, Herrmann-Erlee MPM, Duursma SA 1988 Direct stimulatory effect of growth hormone on DNA synthesis of fetal chicken osteoblasts in culture. Acta Endocrinol (Copenh) 18:294-299.
7. Barnard R, Ng NW, Martin TJ, Waters MJ 1991 Growth hormone (GH) receptors in clonal osteoblast-like cells mediate a mitogenic response to GH. Endocrinology 128:1459-1464.
8. Scheven BBA, Hamilton NJ, Fakkeldij TMV, Duursma SA 1991 Effects of recombinant human insulin-like growth factor I and II (IGF-I/II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regul 1:160-167.
9. Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen EF 1993 Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int 52:222-226.
10. Nilsson A, Swolin D, Enerbach S, Ohlsson C 1995 Expression of functional growth hormone receptors in cultured human osteoblast-like cells. J Clin Endocrinol Metab 80:3483-3488.
11. Ernst N, Froesch ER 1988 Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local syntesis of insuline-like growth factor I. Biochem Biophys Res Commun 151:142-147.
12. Hock JM, Centrella M, Canalis E 1988 Insulin-like growth factor I (IGF-I) has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260.
13. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med 323:1-6.
14. van der Veen EA, Netelenbos JC 1990 Growth hormone (replacement) therapy in adults:bone and calcium metabolism. Horm Res 33 (Suppl 4):65-68.
15. Bouillon R 1991 Growth hormone and bone. Horm Res 36 (Suppl 1):49-55.
16. Wüster C 1993 Growth hormone and bone metabolism. Acta Endocrinol 128 (Suppl 2): 14-18.
17. Slootweg MJ 1993 Growth hormone and bone. Horm Metab Res 25:335-347.
18. Corpas E, Harman SM, Blackman MR 1993 Human growth hormone and human aging. Endocr Rev 14:20-39.
19. Brixen K, Nielsen HK, Mosekilde L, Flyvbjerg A 1990 A short course of human growth hormone treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers. J Bone Miner Res 5:609-618.
20. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM 1990 Effects of short-term administrations of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 70:519-527.
21. Saggese G, Baroncelli GI, Bertelloni S, Cinquanta L, Di Nero G 1993 Effects of long-term treatment with growth hormone in bone and mineral development in children with growth hormone deficiency. J Pediatr 122:37-45.
22. Rosén T, Hansson T, Granhed H, Szucs J, Bengtsson B-Å 1993 Reduced bone mineral content in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh) 129:201-206.
23. Rudman D 1985 Growth hormone, body composition and aging. J Am Geriatr Soc 33:800-807.
24. Kelijman M 1991 Age-related alterations of the growth hormone/insulin-like-growth-factor I axis. J Am Geriatr Soc 39: 295-307.
25. Romagnoli E, Minisola S, Carnevale V, Scarda A, Rosso R, Scarnecchia L, Pacitti MT, Mazzuoli G 1993 Effect of estrogen deficiency on IGF-I plasma levels: Relationship with bone mineral density in perimenopausal women. Calcif Tissue Int 53:1-6.
26. Halse J, Gordeladze JO 1981 Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects. Acta Endocrinol 96:451-457.
27. De la Piedra C, Larranaga ECJ, Castro N, Horcajada C, Rapado A, Herrera Pombo JL 1988 Correlation among plasma osteocalcin, growth hormone, and somatomedin C in acromegaly. Calcif Tissue Int 43:44-45.
28. Ezzat S, Melmed S, Endres D, Eyre DR, Singer FR 1993 Biochemical assessment of bone formation and resorption in acromegaly. J Clin Endocrinol Metab 76:1452-1457.
29. Kotzmann H, Bernecker P, Hübsch P, Pietschmann P, Woloszczuk W, Svoboda T, Geyer G, Luger A 1993 Bone mineral density and parameters of bone metabolism in patients with acromegaly. J Bone Miner Res 8:459-465.
30. Seeman E, Wahner HW, Offord P, Kumar R, Johnson WJ, Riggs BL 1982 Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest 69:1302-1309.
31. Diamond T, Nery L, Posen S 1989 Spinal and peripheral bone mineral densities in acromegaly: the effects of excess growth hormone and hypogonadism. Ann Intern Med 111:567-573.
32. Ho JP, Fig LM, Barkan AL, Shapiro B 1992 Bone mineral density of the axial skeleton in acromegaly. J Nucl Med 33:1608-1612.
33. Riggs BL, Randall RV, Wahner HW, Jowsey J, Kelly PJ, Singh M 1972 The nature of the metabolic bone disorder in acromegaly. J Clin Endocrinol Metab 34:911-918.
34. Halse J, Melsen F, Mosekilde L 1981 Iliac crest bone mass and remodelling in acromegaly. Acta Endocrinol (Copenh) 97: 18-22.
35. Guglielmi G, Giannatempo GM, Blunt BA, Grampp S, Gluer CC, Cammisa M, Genant HK 1995 Spinal bone mineral density by quantitative CT in a normal Italian population. Eur Radiol 5:269-275.
36. Harris WH, Heaney RP 1969 Effect of growth hormone on skeletal mass in adult dogs. Nature 223:403-404.
37. Johansson AG, Burman P, Westermark K, Ljunghall S 1992 The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I. J Intern Med 232:447-452.
38. Binnerts A, Swart GR, Wilson JHP, Hoogerbrugge N, Pols HAP, Birkenhager JC, Lamberts SWJ 1992 The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf) 37:79-87.
39. Whitehead HM, Boreham C, Mc Ilrath EM, Sheridan B, Kennedy L, Atkinson AB, Hadden DR 1992 Growth hormone treatment of adults with growth hormone deficiency: Results of a 13-month placebo controlled cross over study. Clin Endocrinol (Oxf) 36:45-52.
40. Degerblad M, Elgindy N, Hall K, Sjoberg HE, Thoren M 1992 Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinol (Copenh) 126:387-393.
41. O'Halloran DJ, Tsatsoullis A, Whitehouse RW. Holmes SJ, Adams JE, Shalet SM 1993 Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab 76: 1344-1348.
42. Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG 1994 The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Clin Endocrinol (Oxf) 40:383-391.
43. Beshyah SA, Kyd P, Thomas E, Fairney A, Johnston DG 1995 The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults. Clin Endocrinol (Oxf) 42:249-254.
44. Mann DR, Rudman CG, Akinbami MA, Gould KG 1992 Preservation of bone mass in hypogonadal female monkeys with recombinant human growth hormone administration. J Clin Endocrinol Metab 74:1263-1269.
45. Schlechter NL, Russell SM, Spencer EM, Nicoll CS 1986 Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc Natl Acad Sci USA 83:7932-7934.