The influence of estrogen on growth

Current Opinion in Pediatrics

Volumn 9, Issue 4, 1997, Pages 431-436

  Lee, Peter A ^a   Witchel, Selma F ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; AROMATASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; SEX HORMONE;

BODY GROWTH; BONE GROWTH; BONE MATURATION; ENZYME DEFICIENCY; HUMAN; PRIORITY JOURNAL; PUBERTY; SHORT SURVEY; TALL STATURE; VIRILIZATION;

EID: 0030766189     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199708000-00020     Document Type: Short Survey

References (23)

1. Bachrach BE, Smith EP: The role of sex steroids in bone growth and development. Evolving new concepts. The Endocrinologist 1996, 6:362-368.
2. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS: Estrogen resistance caused by a mutation of the estrogen-receptor gene in a man. N Engl J Med 1994, 331:1056-1061.
3. Conte FA, Greenbach MM, Ito Y, Fisher CR, Simpson ER: A syndrome of female pseudohermaphroditism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom). J Clin Endocrinol Metab 1994, 78:1287-1292.
4. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation in the physiological role of estrogen. J Clin Endocrinol Metab 1995, 80:3689-3698. This report of a novel mutation in the aromatase gene involves a brother and sister. The medical history of the sister is similar to that of the patient reported by Conte et al. (J Clin Endocrinol Metab 1994, 78:1287-1292). The brother's lack of skeletal maturity, continued growth, and tall stature are features similar to those of the male with estrogen-receptor defect. Another model of similar features verifies the role of estrogen in growth.
5. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K: Aromatase deficiency in male and female siblings caused by a novel mutation in the physiological role of estrogen. J Clin Endocrinol Metab 1995, 80:3689-3698. This report of a novel mutation in the aromatase gene involves a brother and sister. The medical history of the sister is similar to that of the patient reported by Conte et al. (J Clin Endocrinol Metab 1994, 78:1287-1292). The brother's lack of skeletal maturity, continued growth, and tall stature are features similar to those of the male with estrogen-receptor defect. Another model of similar features verifies the role of estrogen in growth.
6. Vanderschueren-Lodeweyckx M, Massa G, Maes M, Craen M, van Vliet G, Heinrichs C, Malvaux P: Growth-promoting effect of growth hormone and low dose ethinyl estradiol in girls with Turner's syndrome. J Clin Endocrinol Metab 1990, 70:122-126.
7. Caruso-Nicoletti M, Cassorla F, Skerda M, Ross JL, Loriaux DL, Cutler Jr GB: Short-term, low-dose estradiol accelerates ulnar growth in boys. J Clin Endocrinol Metab 1985, 61:896-898.
8. Laue L, Jones J, Barnes KM, Cutler GB Jr: Treatment of familial male precocious puberty with spironolactone, testolactone and deslorelin. J Clin Endocrinol Metab 1993, 76:151-155.
9. Trollmann R, Dörr HG, Strehl E, Katalinic A, Beyer R, Wenzel D: Growth and pubertal development in patients with meningomyelocele: a retrospective analysis. Acta Paediatr 1996, 85:76-80.
10. Zhang Y, Word RA, Fesmire S, Carr BR, Rainey WE: Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1,2, and 3. J Clin Endocrinol Metab 1996, 81:3594-3598.
11. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, Mendelson CR, Bulun SE: Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocrin Rev 1994, 15:342-355.
12. Zachmann M, Prader A, Sobel EH, Crigler Jr JF, Ritzen EM, Atares M, Ferrandez A: Pubertal growth in patients with androgen insensitivity: indirect evidence for the importance of estrogens in pubertal growth in girls. J Pediatr 1986, 108:694-697.
13. Frank GR: The role of estrogen in pubertal skeletal physiology: Epiphyseal maturation and mineralization of the skeleton. Acta Paediatr 1985, 84:627-630.
14. Tsai MJ, O'Malley BW: Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994, 63:451-486.
15. Bulun SE: Aromatase deficiency in women and men: would you have predicted the phenotypes? J Clin Endocrinol Metab 1996, 81:867-871.
16. Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB Jr: Estrogen levels in childhood determined by an ultra-sensitive recombinant cell bioassay. J Clin Invest 1994, 94:2475-2480.
17. Klein KO, Martha Jr PM, Blizzard RM, Herbst T, Rogol AD: A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. II. Estrogen levels as determined by an ultrasensitive bioassay. J Clin Endocrinol Metab 1996, 81:3203-3207. This longitudinal study showed that estrogen levels in boys were very low during the prepubertal years and steadily increased during puberty to the time of peak growth velocity. Estradiol concentrations closely paralleled testosterone levels. Estradiol concentrations also correlated directly with skeletal age, a finding consistent with the hypothesis that estrogen is a stimulus for skeletal maturation.
18. Turner RT, Riggs BL, Spelsberg TC: Skeletal effects of estrogen. Endocrin Rev 1994, 15:275-300.
19. Holmes SJ, Shalet SM: Role of growth hormone and sex steroids in achieving and maintaining normal bone mass. Horm Res 1996, 45:86-93.
20. Bonjour JP, Theintz G, Buchs B, Slosman D, Rizzoli R: Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 1991, 73:555-563.
21. Carmichael KA, Carmichael DH: Bone metabolism and osteopenia in eating disorders. Medicine (Baltimore) 1995, 74:254-267.
22. Katzenellenbogen BS: Estrogen receptors: bioactivities and interactions with cell signaling pathways. Biol Reprod 1996, 54:287-293.
23. Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, DeMets DL: Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 1992, 1326:852-856.