The prothrombinase complex: Assembly and function

Journal of Thrombosis and Thrombolysis

Volumn 4, Issue 3-4, 1997, Pages 357-364

  Spencer, Frederick A ^a   Becker, Richard C ^a   Alexander, John ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 5A; PROTHROMBIN; THROMBIN;

BINDING AFFINITY; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CELL GRANULE; CONFORMATIONAL TRANSITION; ENZYME ANALYSIS; HUMAN; MEMBRANE BINDING; MEMBRANE FLUIDITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; REVIEW; THROMBIN TIME; THROMBOCYTE ACTIVATION;

EID: 0030765674     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008897300003     Document Type: Review

References (46)

1. Mann KG, Lawson JH. The role of the membrane in the expression of the vitamin K-dependent enzymes. Arch Pathol Lab Med 1992;116:1330-1336.
2. Doolittle RF, Feng DF, Johnson MS. Computer-based characterization of epidermal growth factor precursor. Nature 1984;307:558-560.
3. Mann KG, Nesheim ME, Church WR, Haley P, and Krishnaswamy S. Surface-dependent reactions of the vitamin K-dependent enzyme complexes. Blood 1990;76:1-16.
4. Church WR, Boulanger LL, Messier TL, Mann KG. Evidence for a common metal ion-dependent transition in the 4-carboxyglutamic acid domains of several vitamin K dependent proteins. J Biol Chem 1989;264:17882-17887.
5. Malhotra DP, Nesheim ME, Mann KG. The kinetics of activation of normal and gammacarboxyglutamic acid-deficient prothrombins. J Biol Chem 1985;260:279-287.
6. Mann KG, Krishnaswamy S, Lawson JH. Surface dependent hemostasis. Seminars in Hematology 1992;29:213-226.
7. Silverberg SA, Nemerson Y, Zur M. Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. J Biol Chem 1977;252:8481-8488.
8. Krishnaswamy S, Jones KC, Mann KG. Kinetic mechanism of enzyme assembly on phospholipid vesicles. J Biol Chem 1988;263:3823-3834.
9. Nesheim ME, Myrmel KH, Hibbard L, Mann KG. Isolation and characterization of single chain bovine factor V. J Biol Chem 1979;254:508-517.
10. Viskup RW, Tracy PB, Mann KG. The isolation of human platelet factor V. Blood 1987;69:1188-1195.
11. Nesheim ME, NIchols WL, Cole TL, Houston JG, Schenk RB, Mann KG, Bovie EJW Isolation and study of an acquired inhibitor of human coagulation factor V. J Clin Invest 1986;77:405-415.
12. Rand MD, Kalafatis M, Mann KG. Platelet coagulation factor Va: The major secretory platelet phosphoprotein. Blood 1994;83:2180-2190.
13. Tracy PB, Giles AR, Mann KG, Eide LL, Hoogendourn H, Riourd GE. J Clin Invest 1984;74:1221-1228.
14. Bloom JW, Neisheim ME, Mann KG. Phospholipid binding properties of bovine factor V and factor Va. Biochem 1979; 18:4419-4425.
15. Higgins DL, Mann RG. The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles. J Biol Chem 1983;258:6503-6508.
16. Tracy PB, Mann KG. Prothrombinase complex assembly on the platelet surface is mediated through the 74,000 dalton component of factor Va. Proc Natl Acad Sci USA 1983;80: 2380-2384.
17. Kalafahs M, Rand MD, Mann KG. Factor Va membrane interaction is mediated by two regions located on the light chain of the cofactor. Biochem 1994;33:486-493.
18. Krishnaswamy S, Jones KC, Mann KG. Prothrombinase complex assembly on kinetic mechanism of enzyme assembly on phospholipid vesicles. J Biol Chem 1988;263:3823-3834.
19. Krishnaswamy S, Field KA, Edgington TS, Morrissey JH, Mann KG. Role of the membrane surface in the activation of human coagulation factor X. J Biol Chem 1992;267:26110-26120.
20. Pryzdial EL, Mann KG. The association of coagulation factor Xa and factor Va. J Biol Chem 1991;266:8969-8977.
21. Esmon CT. The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity. J Biol Chem 1979; 254:964-973.
22. Nesheim ME, Mann KG Thrombin-catalyzed activation of single chain bovine factor V. J Biol Chem 1979;254:1326-1334.
23. Nesheim ME, Taswell JB, Mann KG. The contribution of bovine factor V and factor Va to the activity of prothrombinase. J Biol Chem 1979;254:10952-10962.
24. Foster BW, Neisheim ME, Mann KG. The factor Xa catalyzed activation of factor V. J Biol Chem 1983;258:13970-13977.
25. Monkovic DD, Tracy PB. Activation of human factor V by Xa and thrombin. Biochemistry 1990;29:1118-1128.
26. Krishnaswamy S, Russell GD, Mann KG. The reassociation of factor Va from its isolated subunits. J Biol Chem 1989; 264:3160.
27. Foster WB, Nesheim ME, Mann KG. The factor Xa catalyzed activation of factor V. J Biol Chem 1983;258:13970-13977.
28. Barton PG, Hanahan DJ. Some lipid protein interactions involved in prothrombin activation. Biochem Biophys Acta 1969;187:319-327.
29. Higgins DC, Callahan PJ, Prendergast FG, Newsheim ME, Mann KG. Lipid mobility in the assembly and expression of the activity of the prothrombinase complex. J Biol Chem 1985;260:3604-3612.
30. Tracy PB, Mann KG. Platelet responses and metabolism. In: Wolmsen H, ed. CRC, 1986:297-394.
31. Tracy PB, Nesheim ME, Mann KG. Coordinate binding of factor Va and factor Xa to the unstimulated platelet. J Biol Chem 1981;256:743-751.
32. Newroth PP, Hundley DA, Esmon CT, et al. Interleuken induces endothelial cell procoagulant activity while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 1986;83:3460-3465.
33. Nesheim ME, Kettner C, Shaw E, Mann KG. Cofactor dependence of factor Xa incorporation into the prothrombinase complex. J Biol Chem 1979;256:6537-6546.
34. Nesheim ME, Eid S, Mann KG. Assembly of the prothrombinase complex in the absence of prothrombin. J Biol Chem 1981;256:9874-9882.
35. Krishnaswamy S, Church WR, Nesheim ME, Mann KG. Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism. J Biol Chem 1987;262:3291-3299.
36. Kane WH, Lindhout MJ, Jackson CM, Majerus PW. Factor Va dependent binding of factor Xa to human platelets. J Biol Chem 1980;255:1170-1174.
37. Miletich JP, Jackson CM, Majerus PW Properties of the factor Xa binding site on human platelets. J Biol Chem 1978;253:6908-6916.
38. Miletich JP, Majerus DW, Majerus PW. Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J Clin Invest 1978;62:824-831.
39. Miletich JP, Kane WH, Hoffman SL, Stanford N, Majerus PW. Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015-1022.
40. Kane WH, Lindhout MJ, Jackson CM, Majerus PW. Factor Va-dependent binding of factor-Xa to human platelets. J Biol Chem 1981;255:1170-1174.
41. Tracy PB, Peterson JM, Nesheim ME, McDuffie FC, Mann KG. Interaction of coagulation factor V and factor Va with platelets. J Biol Chem 1979;254:10354-10361.
42. Tracy PB, Peterson JM, Nesheim ME, McDuffie FC, Mann KG. In: Taylor FB Jr, Mann KG, eds. The Regulation of Coagulation. New York: Elsevier, 1980;237-243.
43. Mann KG, Nesheim ME, Church WR, Huley P, Krishnaswamy S. Surface-dependent reactions of the vitamin K-dependent enzyme complexes. Blood 1990;76:1-16.
44. Krishnaswamy S. Prothrombinase complex assembly: Contributions of protein-protein and protein-membrane interactions towards complex formation. J Biol Chem 1990;265: 3708.
45. Krishnaswamy S, Jones KC, Mann KG. Kinetic mechanism of enzyme assembly on phospholipid vesicles. J Biol Chem 1988;263:3823-3834.
46. Swords NA, Mann KG. The assembly of the prothrombinase complex on adherent platelets. Arteriosclerosis and Thrombosis 1993;13:1602-1612.