Magnesium and the N-methyl-D-aspartate receptor antagonist dizocilpine maleate neither increase glucose use nor induce a 72-kilodalton heat shock protein expression in the immature rat brain

Pediatric Research

Volumn 42, Issue 4, 1997, Pages 472-477

  Gilland, Eric ^a   Bona, Elsa ^a   Levene, Malcolm ^b   Hagberg, Henrik ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIZOCILPINE MALEATE; HEAT SHOCK PROTEIN; MAGNESIUM SULFATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEMALE; GLUCOSE UTILIZATION; HIPPOCAMPUS; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; TOXICITY TESTING;

EID: 0030765652     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199710000-00008     Document Type: Article

References (52)

1. Tan WKM, Williams CE, Gunn AJ, Mallard CE, Gluckman PD 1992 Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep. Ann Neurol 32:677-682
2. Hattori H, Morin AM, Schwartz PH, Fujikawa DG, Wasterlain CG 1989 Posthypoxic treatment with MK801 reduces hypoxic-ischemic damage in the neonatal rat. Neurology 39:713-718
3. Olney JW 1993 Role of excitotoxins in developmental neuropathology. APMIS 40:103-112
4. Johnston MV 1993 Cellular alterations associated with perinatal asphyxia. Clin Invest Med 16:122-132
5. Hagberg H, Gilland E, Diemer NH, Andiné P 1994 Hypoxia-ischemia in the neonatal rat brain: histopathology after post-treatment with NMDA and non-NMDA receptor antagonists. Biol Neonate 66:206-213
6. Iseri LT, French JH 1984 Magnesium: nature's physiologic calcium blocker. Am Heart J 108:188-193
7. Nadler JL, Goodson S, Rude RK 1987 Evidence that prostacyclin mediates the vascular action of magnesium in humans. Hypertension 9:379-383
8. Reinhart RA 1991 Clinical correlates of the molecular and cellular actions of magnesium on the cardiovascular system. Am Heart J 121:1513-1521
9. Schanne FAX, Gupta RK, Stanton PK 1993 31P-NMR study of transient ischemia in rat hippocampal slices in vitro. Biochim Biophys Acta 1158:257-263
10. Altura BM, Barbour RL, Dowd TL, Wu F, Altura BT, Gupta RK 1993 Low extracellular magnesium induces intracellular free Mg deficits, ischemia, depletion of high-energy phosphates and cardiac failure in intact working rat hearts. Biochim Biophys Acta 1182:329-332
11. Ascher P, Nowak L 1987 Electrophysiological studies on NMDA receptors. Trends Neurosci 10:284-288
12. Nowak L, Bregestovski P, Ascher P 1984 Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307:462-465
13. Harrison NL, Simmonds MA 1985 Quantitative studies on some antagonists of N-methyl-D-aspartate in slices of rat cerebral cortex. Br J Pharmacol 84:381-391
14. Morrisett RA, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS 1990 Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Dev Brain Res 56:257-262
15. McIntosh TK, Vink R, Yamaki I, Faden AI 1989 Magnesium protects against neurological deficit after brain injury. Brain Res 482:252-260
16. Izumi Y, Roussel S, Pinard E, Seylaz J 1991 Reduction of infarct volume by magnesium after medial cerebral artery occlusion in rats. J Cereb Blood Flow Metab 11:1025-1030
17. Tsuda T, Kogure K, Nishioka K, Watanabe T 1991 Mg2+ administered up to twenty-four hours following reperfusion prevents ischemic damage of the CA1 neurons in the rat hippocampus. Neuroscience 44:335-341
18. McDonald JW, Silverstein FS, Johnston MV 1990 Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett 109:234-238
19. Spandou E, Soubasi V, Guiba-Tziampiri O, Karkavelas C, Kaiki-Astara A, Doukas V 1995 Magnesium monotherapy or in combination with ketamine in perinatal hypoxic-ischemic brain damage (preliminary study). Pediatr Res 38:455
20. Thordstein M, Bågenholm R, Thiringer K, Kjellmer I 1993 Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxicischemic brain damage in the rat. Pediatr Res 34:23-26
21. Nelson KB, Grether JK 1995 Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants? Pediatrics 95:263-269
22. Levene M, Blennow M, Whitelaw A, Hankö E, Fellman V, Hartley R 1995 Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia. Arch Dis Child 73:174-177
23. Crosby G, Crane AM, Sokoloff L 1982 Local changes in cerebral glucose utilization during ketamine anesthesia. Anesthesiology 56:437-443
24. Weissman AD, Dam M, London ED 1987 Alterations in local cerebral glucose utilization induced by phencyclidine. Brain Res 435:29-40
25. Nehls DG, Kurumaji A, Park CK, McCulloch J 1988 Differential effects of competitive and non-competitive N-methyl-D-aspartate antagonists on glucose use in the limbic system. Neurosci Lett 91:204-210
26. Olney JW, Labruyere J, Madelon TP 1989 Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362
27. Sharp FR, Jasper P, Hall J, Noble L, Sagar SM 1991 MK-801 and ketamine induced heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol 30:801-809
28. Hargreaves RJ, Rigby M, Smith D, Hill RG, Iversen LL 1993 Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism. Neurochem Res 18:1263-1269
29. Olney JW, Farber NB 1995 NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia. Neuropharmacology 13:335-345
30. Sprang GK, Brown IR 1987 Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization. Mol Brain Res 3:89-93
31. Vass K, Welch WJ, Nowak Jr. TS 1988 Localisation of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropathol 77:128-135
32. Ferriero DM, Soberano HQ, Simon RP, Sharp FR 1990 Hypoxia-ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain. Dev Brain Res 53:145-150
33. Dwyer BE, Nishimura RN, Brown IR 1989 Synthesis of the major inducible heat shock protein in rat hippocampus after neonatal hypoxia-ischemia. Exp Neurol 104:28-31
34. Sharp FR, Butman M, Wang S, Koistinaho J, Graham SM, Sager SM, Noble L, Berger P, Longo FM 1992 Haloperidol prevents induction of tsp 70 heat shock gene in neurones injured by phencyclidine (PCP), MK801, and ketamine. J Neurosci Res 33:605-616
35. Farber NB, Wozniak DF, Price MT, Labruyere J, Huss J, St. Peter H, Olney JW 1995 Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia? Biol Psychiatry 38:788-796
36. Romijn HJ, Hofman MA, Gramsbergen A 1991 At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby? Early Hum Dev 26:61-67
37. Rice JE, Vannucci RC, Brierley JB 1981 The influence of immaturity on hypoxicischemic brain damage in the rat. Ann Neurol 9:131-141
38. Andiné P, Thordstein M, Kjellmer I, Nordborg C, Thiringer K, Wennberg E, Hagberg H 1990 Evaluation of brain damage in a rat model of neonatal hypoxicischemia. J Neurosci Methods 35:253-260
39. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M 1977 The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916
40. Gilland E, Hagberg H 1996 NMDA-receptor dependent increase of cerebral glucose utilization after hypoxia-ischemia in the neonatal rat. J Cereb Blood Flow Metab 16:1005-1013
41. Vannucci RC, Christensen MA, Stein DT 1989 Regional cerebral glucose utilization in the immature rat: effect of hypoxia-ischemia. Pediatr Res 26:208-214
42. Lowry OH, Passonneau JV 1972 A Flexible System of Enzymatic Analysis. Academic Press, New York, pp 174-177
43. Sherwood NM, Timiras PS 1970 A Stereotaxic Atlas of the Developing Rat Brain. University California Press, Los Angeles, pp 24-69
44. McRae A, Gilland E, Bona E, Hagberg H 1995 Microglia activation after neonatal hypoxic-ischemia. Dev Brain Res 84:245-252
45. 44b. Gilland E, Puka-Sundvall M, Hillered L, Hagberg H 1997 NMDA-receptor dependent mitochondrial dysfunction and sustained energy utilization after hypoxiaischemia in the immature rat. J Cereb Blood Flow Metab 17(suppl 1): S146
46. Thoresen M, Bågenholm R, Løberg EM, Apricena F, Kjellmer I 1996 Posthypoxic cooling of neonatal rats provides protection against brain injury. Arch Dis Child 74:F3-F9
47. Dehaan HH, Gunn AJ, Williams CE, Heymann MA, Gluckman PD 1997 Magnesium sulfate therapy during asphyxia in near term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol 176:18-27
48. Edvinsson L, MacKenzie ET, McCulloch J 1993 Cerebral Blood Flow and Metabolism. Raven Press, New York, pp 487-491
49. Olney JW 1994 Neurotoxicity of NMDA receptor antagonists: an overview. Psychopharmacol Bull 30:533-540
50. Miller MW, Robertson RT 1993 Development of cingulate cortex: proteins, neurons, and afferents. In: Vogt BA, Gabriel M (eds) Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook. Birkhäuser, Boston, pp 151-180
51. Marshall BE, Longnecker DE 1990 General anesthetics. In: Gilman AG, Rall TW, Nies AS, Taylor P (eds) The Pharmacological Basis of Therapeutics. Pergamon Press, New York, pp 306-307
52. Constantine-Paton M 1994 Effects of NMDA receptor antagonists on the developing brain. Psychopharmacol Bull 30:561-565