Recruiting the 2-5A system for antisense therapeutics

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 203-206

  Torrence, Paul F ^a   Xiao, Wei ^a   Li, Guiying ^a   Cramer, Hagen ^a   Player, Mark R ^a   Silverman, Robert H ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLIC ACID; ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTIVIRUS AGENT; ENZYME ACTIVATOR; MESSENGER RNA; RIBONUCLEASE;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DNA RNA HYBRIDIZATION; DRUG TARGETING; PRIORITY JOURNAL; RNA CLEAVAGE;

EID: 0030765267     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.203     Document Type: Conference Paper

References (7)

1. CIRINO, N.M., LI, G., XIAO, W., TORRENCE, P.F., and SILVERMAN, R.H. (1997). Targeting RNA for decay in respiratory syncy-tial virus-infected cells with 2′->5′ oligoadenylate antisense. Proc. Natl. Acad. Sci. USA 94, 1937-1942.
2. JOHNSTON, M.I., and TORRENCE, P.F. (1984). The role of interferon-induced proteins, double-stranded RNA and 2′,5′-oligoadenylate in the interferon-mediated inhibition of viral translation. In: Interferon: Mechanism of Production and Action. R.M. Freidman, ed. (Elsevier, Amsterdam), pp. 189-298.
3. LESIAK, K., KHAMMEI, S., and TORRENCE, P.F. (1993). 2′,5′-Oligoadenylate: antisense chimeras - Synthesis and properties. Bioconj. Chem. 4, 467-472.
4. MAITRA, R.K., LI, G., XIAO, W., DONG, B., TORRENCE, P.F., and SILVERMAN, R.H. (1995). Catalytic cleavage of an RNA target by 2-5A antisense and RNase L. J. Biol. Chem. 270, 15071-15075.
5. MARAN, A., MAITRA, R.K., KUMAR, A., DONG, B., XIAO, W., LI, G., WILLIAMS, B.R.G., TORRENCE, P.F., and SILVERMAN, R.H. (1994). Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A. antisense chimeras. Science 265, 789-792.
6. TORRENCE, P.F., MAITRA, R.K., LESIAK, K., KHAMNEI, S., SHOU, A., and SILVERMAN, R.H. (1993). Targeting RNA for degradation with a (2′-5′)oligoadenylate-antisense chimera. Proc. Natl. Acad. Sci. USA 90, 1300-1304.
7. TORRENCE, P.F., XIAO, W., LI, G., LESIAK, K., KHAMNEI, S., MARAN, A., MAITRA, R., DONG, B., and SILVERMAN, R.H. (1994). 2′-5′-OligoadenyIate antisense chimeras for targeted ablation of RNA. In: Carbohydrate Modifications in Antisense Research. Y. S. Sanghvi and P. D. Cool, eds. (American Chemical Society, Washington, DC), pp. 119-132.