Analytical profile of polymorphism of LR-B 0/81

Bollettino Chimico Farmaceutico

Volumn 136, Issue 5, 1997, Pages 474-481

  Notarangelo, D ^a   Ghetti, P ^a   Stradi, R ^a   Salimbeni, A ^b   Pini, E ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Lusochimica SpA   (Italy)

Author keywords

antihypertensive drug; DSC; IR; micronization; polymorphism; stability relationship; XRD

Indexed keywords

ANTIHYPERTENSIVE AGENT; LRB 081; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; FOURIER TRANSFORMATION; INFRARED SPECTROPHOTOMETRY; THERMAL ANALYSIS; X RAY DIFFRACTION;

EID: 0030765051     PISSN: 00066648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. R. Cirillo, A. Renzetti, P. Cucchi, M. Guelfi, A. Salimbeni, S. Caliari, A. Castellucci, S. Evangelista, A. Subissi, A. Giacchetti: "Pharmacology of LR-B 0/81, a new highly potent, selective and orally active, nonpeptide angiotensin II AT1 receptor antagonist" British J. Pharm, 1995, 114, 1117-24.
2. A. Salimbeni, R. Canevotti, F. Paleari, D. Poma, S. Caliari, F. Fici, R. Cirillo, A. Renzetti, A. Subissi, L. Belvisi, G. Bravi, C. Scolastico, A. Giacchetti: "N-3-Substituted Pyrimidinones as potent, orally active AT1 selective angiotensin II receptor antagonist" J.Med.Chem, 1995, vol 38.
3. M. di Muro "Aspetti regolatori" Pharmaceutical solid state congress, Museo della scienza e della tecnica, Milano 19-10-1995.
4. P. Ghetti, A. Ghidini, R. Stradi: "Analyitical potential of FT-IR Thermomicroscopy: application to some cases of polymorphism" Bollettino. chim. farm. ecc.
5. A. Burger, R. Ramberger: "On the polymorphism of pharmaceuticals and other molecular crystals". Mikrochimica Acta 1979, II 259-71.
6. A. Salimbeni: communication.