A comparison of the ventilatory response of sleeping newborn lambs to step and progressive hypoxaemia

Journal of Physiology

Volumn 503, Issue 1, 1997, Pages 203-214

  Cohen, Gary ^a   Malcolm, Girvan ^a   Henderson Smart, David ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ANIMAL EXPERIMENT; ARTERIAL OXYGEN SATURATION; ARTICLE; CHEMORECEPTOR REFLEX; HYPERPNEA; HYPOXEMIA; LUNG MINUTE VOLUME; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SLEEP; AGE; COMPARATIVE STUDY; CONTROLLED STUDY; FETUS; LAMB; OXYGEN CHEMOREFLEX; PERINATAL PERIOD; PULSE OXIMETER; RESPIRATORY FUNCTION; STEADY STATE; VENTILATORY RESPONSE;

EID: 0030764828     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.203bi.x     Document Type: Article

References (44)

1. BACON, D. S., AFIFI, M. S., GRIEBEL, J. A. & CAMPORESI, E.M. (1990). Cerebrocortical oxygenation and ventilatory response during sustained hypoxia. Respiration Physiology 80, 245-258.
2. BELENKY, D. A., STANDAERT, T. A. & WOODRUM, D. E. (1979). Maturation of hypoxic ventilatory response of the newborn lamb. Journal of Applied Physiology 47, 927-930.
3. BLANCO, C. E., DAWES, G. S., HANSON, M. A. & MCCOOKE, H. B. (1984). The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs. Journal of Physiology 351, 25-37.
4. BODDY, K., DAWES, G. S., FISHER, R., PINTER, S. & ROBINSON, J. S. (1974). Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. Journal of Physiology 243, 599-618.
5. BONORA, M., MARLOT, D., GAUTIER, H. & DURON, B. (1984). Effects of hypoxia on ventilation during postnatal development in conscious kittens. Journal of Applied Physiology 56, 1464-1471.
6. BRADY, J. P. & CERUTI, E. (1966). Chemoreceptor reflexes in the newborn infant: effects of varying degrees of hypoxia on heart rate and ventilation in a warm environment. Journal of Physiology 184, 631-645.
7. 2 in awake newborn lambs. Journal of Applied Physiology 52, 428-433.
8. BUREAU, M. A., CÔTÉ, A., BLANCHARD, P. W., HOBBS, S., FOULON, P. & DALLE, D. (1986). Exponential and diphasic ventilatory response to hypoxia in conscious lambs. Journal of Applied Physiology 81, 836-842.
9. BUREAU, M. A., LAMARCHE, J., FOULON, P. & DALLE, D. (1985). The ventilatory response to hypoxia in the newborn lamb after carotid body denervation. Respiration Physiology 60, 109-119.
10. BUREAU, M. A., ZINMAN, R., FOULON, P. & BEGIN, R. (1984). Diphasic ventilatory response to hypoxia in newborn lambs. Journal of Applied Physiology 56, 84-90.
11. CARROLL, J. L. & BUREAU, M. A. (1987). Decline in peripheral chemoreceptor excitatory stimulation during acute hypoxia in the lamb. Journal of Applied Physiology 63, 795-802.
12. 2 in the awake lamb: role of the carotid chemoreceptors. Journal of Applied Physiology 71, 2083-2088.
13. COHEN, G. L. & HENDERSON-SMART, D. J. (1990). A modified rebreathing method to study the ventilatory response of the newborn to carbon dioxide. Journal of Developmental Physiology 14, 295-301.
14. CÔTÉ, A., YUNIS, P., BLANCHARD, P. W., MORTOLA, J. P. & BUREAU, M. A. (1988). Dynamics of breathing in the hypoxic awake lamb. Journal of Applied Physiology 64, 354-359.
15. CROSS, K. W. & OPPÉ, T. E. (1952). The effect of inhalation of high and low concentrations of oxygen on the respiration of the premature infant. Journal of Physiology 117, 38-55.
16. DAWES, G. S., MOTT, J. C. & WIDDICOMBE, J. G. (1955). The patency of the ductus arteriosus in newborn lambs and its physiological consequences. Journal of Physiology 128, 361-383.
17. CO2 on the time course of ventilation. Respiration Physiology 3, 367-369.
18. EDEN, G. J. & HANSON, M. A. (1987). Maturation of the respiratory response to acute hypoxia in the newborn rat. Journal of Physiology 392, 1-9.
19. EYZAGUIRRE, C. & ZAPATA, P. (1984). Perspectives in carotid body research. Journal of Applied Physiology 57, 931-957.
20. GOZAL, D., ARENS, R., OMLIN, K. J., MARCUS, C. L. & KEENS T. G. (1994). Maturational differences in step vs. ramp hypoxic and hypercapnic ventilatory responses. Journal of Applied Physiology 76, 1968-1975.
21. HADDAD, G. G., GANDHI, M. R. & MELLINS, R. B. (1982). Maturation of ventilatory response to hypoxia in puppies during sleep. Journal of Applied Physiology 52, 309-314.
22. HENDERSON-SMART, D. J. & COHEN, G. L (1988). Chemical control of breathing in early life. In Sudden Infant Death Syndrome: Cardio-Respiratory Mechanisms and Interventions, ed. SCHWARTZ, P. J., SOUTHALL, D. P. & VALDES-DEPENA, M., pp. 276-289. New York Academy of Sciences, New York.
23. HENDERSON-SMART, D. J. & READ, D. J. C. (1979). Ventilatory responses to hypoxaemia during sleep in the newborn. Journal of Developmental Physiology 1, 195-208.
24. HUNT, C. E. (1992). Sudden infant death syndrome. In Respiratory Control Disorders in Infants and Children, ed. BROUILLETTE, R. T. & HUNT, C. E., pp. 190-211. Williams & Wilkins, Baltimore, MD, USA.
25. JEFFERY, H. E. & READ, D. J. C. (1980). Ventilatory responses of newborn calves to progressive hypoxia in quiet and active sleep. Journal of Applied Physiology 48, 892-895.
26. JOHNSTON, B. M. & GLUCKMAN, P. D. (1993). Peripheral chemoreceptors respond to hypoxia in pontine-lesioned fetal lambs in utero. Journal of Applied Physiology 75, 1027-1034.
27. KUMAR, P. & HANSON, M. A. (1988). Re-setting of the hypoxic sensitivity of aortic chemoreceptors in the new-born lamb. Journal of Developmental Physiology 11, 199-206.
28. LAFRAMBOISE, W. A., GUTHRIE, R. D., STANDAERT, T. A. & WOODRUM, D. (1983). Pulmonary mechanics during ventilatory response to hypoxemia in the newborn monkey. Journal of Applied Physiology 55, 1008-1014.
29. LAFRAMBOISE, W. A., STANDAERT, T. A., WOODRUM, D. & GUTHRIE, R. D. (1981). Occlusion pressures during the ventilatory response to hypoxaemia in the newborn monkey. Journal of Applied Physiology 51, 1169-1174.
30. LAHIRI, S. (1983). Some aspects of the regulation of chemosensory function of arterial chemoreceptors. In Modelling and Control of Breathing, ed. WHIPP, B. J. & WIBERO, D. M., pp. 20-28. Elsevier, New York.
31. MCBRIDE, B. & WHITELAW, W. A. (1981). A physiological stimulus to upper airway receptors in humans. Journal of Applied Physiology 51, 1189-1197.
32. MAHUTTE, C. K. & REBUCK, A. S. (1978). Influence of rate of induction of hypoxia on the ventilatory response. Journal of Physiology 284, 219-227.
33. MARCHAL, F., BAIRAM, A., HAOUZI, P., CRANCE, J. P., DI GIULIO, C., VERT, P. & LAHIRI, S. (1992). Carotid chemoreceptor response to natural stimuli in the newborn kitten. Respiration Physiology 87, 183-193.
34. NEUBAUER, J. A., SANTIAGO, T. V., POSNER, M. A. & EDELMAN, N. H. (1985). Ventral medullary pH and ventilatory responses to hyper-perfusion and hypoxia. Journal of Applied Physiology 58, 1659-1668.
35. PRAUD, J., CANET, E., KIANICKA, I., GAULTIER, C. & BUREAU, M. (1993). Vagal and chemoreceptor influences on abdominal muscle activity in awake lambs during hypoxia. Journal of Applied Physiology 74, 1689-1696.
36. PURVES, M. J. (1966). The effects of hypoxia in the newborn lamb before and after denervation of the carotid chemoreceptors. Journal of Physiology 185, 60-77.
37. RAHILLY, P. M. (1980). Effects of 2% carbon dioxide, 0·5% carbon dioxide anil 100% oxygen on cranial blood flow in the human neonate. Pediatrics 233, 45-62.
38. REBUCK, A. S. & SLUTSKY, A. S. (1981). Measurement of ventilatory responses to hypercapnia and hypoxia. In Regulation of Breathing, Part II, ed. HORNBEIN, T. F., pp. 745-772. Marcel Dekker, New-York.
39. RIGATTO, H., BRADY, J. P. & DE LA TORRE VERDUZCO, R. (1975). Chemoreceptor reflexes in preterm infants: I. The effect of gestational and postnatal age on the ventilatory response to inhalation of 100% and 15% oxygen. Pediatrics 55, 604-613.
40. 2 in preterm infants. American Review of Respiratory Diseases in Children 143, 101-104.
41. TAYLOR, M. B. & WHITWAM, J. G. (1988). The accuracy of pulse oximeters. Anaesthesia 43, 29-232.
42. WALKER, A. M. & DE PREU, N. D. (1991). Preterm birth in lambs: sleep patterns and cardiorespiratory changes. Journal of Developmental Physiology 16, 139-145.
43. 2 in newborn piglets. Journal of Physiology 456, 39-48.
44. WOODRUM, D. E., STANDAERT, T. A., MAYOCK, D. E. & GUTHRIE, D. E. (1981). Hypoxic ventilatory response in the newborn monkey. Pediatric Research 15, 367-370.