β-Tubulin genes and the basis for benzimidazole sensitivity of the opportunistic fungus Cryptococcus neoformans

Microbiology

Volumn 143, Issue 6, 1997, Pages 2003-2008

  Cruz, Maria Cristina ^a   Edlind, Thomas ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Benzimidazole; Cryptococcus neoformans; Drug resistance; Microtubule; Tubulin

Indexed keywords

ALBENDAZOLE; ANTIFUNGAL AGENT; BENZIMIDAZOLE; BETA TUBULIN; COMPLEMENTARY DNA; FUNGAL DNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG SENSITIVITY; FUNGAL GENETICS; FUNGUS MUTANT; GENE EXPRESSION; INTRON; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; START CODON;

FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 0030764657     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-6-2003     Document Type: Article

References (27)

1. Cooley, R. N. & Caten, C. E. (1993). Molecular analysis of the Septoria nodorum β-tubulin gene and characterization of a benomyl-resistance mutation. Mol Gen Genet 237, 58-64.
2. Cruz, M. C., Barlett, M. S. & Edlind, T. D. (1994). In vitro susceptibility of the opportunistic fungus Cryptococcus neoformans to anthelmintic benzimidazoles. Antimicrob Agents Chemother 38, 378-380.
3. Davidse, L. C. & Flach, W. (1977). Differential binding of methyl benzimidazole-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans. J Cell Biol 72, 174-193.
4. Davis, L. G., Dibner, M. D. & Battey, J. F. (1986). Basic Methods in Molecular Biology. New York: Elsevier.
5. Edman, J. C. & Kwon-Chung, K. J. (1990). Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation. Mol Cell Biol 10, 4538-4544.
6. Fujimara, M. K., Oeda, M., Inoue, H. & Kato, T. (1992). A single amino-acid substitution in the β-tubulin gene of Neurospora crassa confers both carbendazim resistance and diethofencarb sensitivity. Curr Genet 21, 399-404.
7. Goldman, G. H., Temmerman, W., Jacobs, D., Contreras, R., Van Montagu, M. & Herrrera-Estrella, A. (1993). A nucleotide substitution in one of the β-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate. Mol Gen Genet 240, 73-80.
8. Hay, J. R. (1991). Clinical manifestations and management of cryptococcoses in the compromised patient. In Fungal Infection in the Compromised Patient. Edited by D. W. Warnock & M. D. Richardson. New York: John Wiley.
9. Jung, M. K. & Oakley, B. R. (1990). Identification of an amino acid substitution in the benA β-tubulin gene of Aspergillus nidulans that confers thiabendazole resistance and benomyl super-sensitivity. Cell Motil Cytoskel 17, 87-94.
10. Jung, M. K., Wilder, I. B. & Oakley, B. R. (1992). Amino acid alterations in the benA (β-tubulin) gene of Aspergillus nidulans that confer benomyl resistance. Cell Motil Cytoskel 22, 170-174.
11. Katiyar, S. K. & Edlind, T. D. (1994). β-Tubulin genes of Trichomonas vaginalis. Mol Biochem Parasitol 64, 33-42.
12. Katiyar, S. K., Gordon, V. R., McLaughlin, G. L. & Edlind, T. D. (1994). Antiprotozoal activities of benzimidazoles and correlations with β-tubulin sequence. Antimicrob Agents Chemother 38, 2086-2090.
13. Kozak, M. (1986). Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44, 283-292.
14. Lacey, E. (1988). The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of resistance to benzimidazoles. Int J Parasitol 18, 885-936.
15. Lewis, S. A., Gilmartin, M. E., Hall, J. L. & Cowan, N. J. (1985). Three expressed sequences within the human β-tubulin multigene family each define a distinctive isotype. J Mol Biol 182, 11-20.
16. Li, J., Katiyar, S. K. & Edlind, T. D. (1996). Site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin: interaction between residue 167 and benzimidazole compounds. FEBS Lett 385, 7-10.
17. May, S. G., Tsang, M. L. S., Smith, H., Fidel, S. & Morris, N. R. (1987). Aspergillus nidulans β-tubulin genes are unusually divergent. Gene 55, 231-243.
18. Moore, T. D. E. & Edman, J. C. (1993). The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol 13, 1962-1970.
19. Ohrbach, M. J., Porro, E. B. & Yanofsky, C. (1986). Cloning and characterization of the gene for β-tubulin from a benomyl resistant mutant of Neurospora crassa and its use as a dominant selectable marker. Mol Cell Biol 6, 2452-2461.
20. Panther, L. A. & Sande, M. A. (1990). Cryptococcal meningitis in the acquired immunodeficiency syndrome. Semin Respir Infect 5, 138-145.
21. Powderly, W. G. (1992). Therapy for cryptococcal meningitis in patients with AIDS. Clin Infect Dis 14, S54-S59.
22. Russo, P., Juuti, J. T. & Raudaskoski, M. (1992). Cloning, sequence and expression of a β-tubulin-encoding gene in the homobasidiomycete Schizophyllum commune. Gene 119, 175-182.
23. Sirawaraporn, W., Cao, M., Santini, D. V. & Edman, J. C. (1993). Cloning, expression, and characterization of Cryptococcus neoformans dihydrofolate reductase. J Biol Chem 268, 8888-8892.
24. Sugar, A. M., Stern J. J. & Dupont, B. (1990). Overview: treatment of cryptococcal meningitis. Rev Infect Dis 12, S338-S348.
25. Thomas, J. H., Neff, N. F. & Botstein, D. (1985). Isolation and characterization of mutations in the β-tubulin gene of Saccharomyces cerevisiae. Genetics 112, 715-734.
26. Tolkacheva, T., McNamara, P., Piekarz, E. & Courchesne, W. (1994). Cloning of a Cryptococcus neoformans gene, GPA1, encoding a G-protein α-subunit homolog. Infect Immun 62, 2849-2856.
27. Williamson, P. R. (1994). Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J Bacteriol 176, 656-664.