Adverse events after discontinuing medications, in elderly outpatients

Archives of Internal Medicine

Volumn 157, Issue 19, 1997, Pages 2205-2210

  Graves, Taylor ^b   Hanlon, Joseph T ^a   Schmaler, Kenneth E ^b   Landsman, Pamela B ^b   Samsa, Gregory P ^b   Pieper, Carl F ^b   Weinberger, Morris ^b  

^a DURHAM UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIGOUT AGENT; BENZODIAZEPINE DERIVATIVE; CARDIOVASCULAR AGENT; GASTROINTESTINAL AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; TRICYCLIC ANTIDEPRESSANT AGENT;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; HEALTH CARE UTILIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; WITHDRAWAL SYNDROME;

EID: 0030764340     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.157.19.2205     Document Type: Article

References (40)

1. Ouslander JG. Drug therapy in the elderly. Ann Intern Med. 1981;95:711-722.
2. Kroenke K, Pinholt EM. Reducing polypharmacy in the elderly: a controlled trial of physician feedback. J Am Geriatr Soc. 1990;38:31-36.
3. Stewart RB. Polypharmacy in the elderly: a fait accompli? Drug Intell Clin Pharm. 1990;24:321-323.
4. Nolan L, O'Malley K. Prescribing for the elderly, I: sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc. 1988;36:142-149.
5. Hurwitz N. Predisposing factors in adverse reactions to drugs. BMJ. 1969;1: 536-539.
6. Williamson J, Chopin JM. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing. 1980;9:73-80.
7. Montamat SC, Cusack BJ, Vestal RE. Management of drug therapy in the elderly. N Engl J Med. 1989;321:303-309.
8. Hemminski E, Heikkila J. Elderly people's compliance with prescriptions, and quality of medication. Scand J Soc Med. 1975;3:87-92.
9. Hulka B, Cassel J, Kupper L, Burdette JA. Communication, compliance, and concordance between physician and patients with prescribed medications. Am J Public Health. 1976;66:847-853.
10. Vestal RE. Drug use in the elderly: a review of problems and special considerations. Drugs. 1978;16:358-382.
11. Cooper JW. Effect of initiation, termination, and reinitiation of consultant clinical pharmacist services in a geriatric long-term care facility. Med Care. 1985; 23:84-88.
12. Hanlon JT, Schmader K, Lewis I. Adverse drug reactions. In: Delafuente JC, Stewart RB, eds. Therapeutics in the Elderly. 2nd ed. Cincinnati, Ohio: Harvey Whitney Books; 1995:212-227.
13. Hodding GC, Jann M, Ackerman IP. Drug withdrawal syndromes: a literature review. West J Med. 1980;133:383-391.
14. Frishman WH. Beta-adrenergic blocker withdrawal. Am J Cardiol. 1987;59:26F-32F.
15. Busto U, Sellers EM, Naranjo CA, Cappell HD, Sanchez-Craig M, Simpkins J. Withdrawal reaction after long term therapeutic use of benzodiazepines. N Engl J Med. 1986;315:854-859.
16. Hull SM, Mackintosh A. Discontinuation of maintenance digoxin therapy in general practice. Lancet. 1977;2:1054-1055.
17. Taggert AJ, Johnson GD, McDevitt DG. Digoxin withdrawal after cardiac failure in patients with sinus rhythm. J Cardiovasc Pharmacol. 1983;5:229-234.
18. Daly C, Edwards H. Withdrawal of digoxin in general practice in elderly patients. Jr Med J. 1983;76:19-20.
19. Wilkins CE, Khurana MS. Digitalis withdrawal in elderly nursing home patients. J Am Geriatr Soc. 1985;33:850-851.
20. Sueta CA, Carey TS, Burnett CK. Reassessment of indications for digoxin are patients being withdrawn? Arch Intern Med. 1989;149:609-612.
21. Packer M, Gheorghiade M, Young JB, et al. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. N Engl J Med. 1993;329:1-7.
22. Walma EP, Hoes AW, Prins A, Boukes FS, van der Does E. Withdrawing long-term diuretic therapy in the elderly: a study in general practice in the Netherlands. Fam Med. 1993;25:661-664.
23. de Jonge JW, Knottnerus JA, van Zutphen WM, de Bruijne GA. Review: trials of withdrawal of diuretics. Age Ageing. 1993;22:382-388.
24. deJonge JW, Knottnerus JA, van Zutphen WM, et al. Short term effect of withdrawal of diuretic drugs prescribed for ankle oedema. BMJ. 1994;308:511-513.
25. Gerety MB, Cornell JE, Plichta DT, Eimer M. Adverse events related to drugs and drug withdrawal in nursing home residents. J Am Geriatr Soc. 1993;41:1326-1332.
26. Hanlon JT, Weinberger M, Samsa GP, et al. A randomized controlled trial of a clinical pharmacist intervention with elderly outpatients with polypharmacy. Am J Med. 1996;100:428-437.
27. Schmader K, Hanlon JT, Weinberger M, et al. Appropriateness of medication prescribing in ambulatory elderly patients. J Am Geriatr Soc. 1994;42:1241-1247.
28. McEvoy GK, ed. American Hospital Formulary Service Drug Information. Bethesda, Md: American Society of Hospital Pharmacists Inc; 1993.
29. Wilson JD, Braunwald E, Isselbacher KJ, et al, eds. Harrison's Principles of Internal Medicine. 12th ed. New York, NY: McGraw-Hill Book Co; 1991.
30. Olsson G, Hjemdahl P, Rehnqvist N. Rebound phenomena following gradual withdrawal of chronic metoprolol treatment in patients with ischemic heart disease. Am Heart J. 1984;108:454-462.
31. Houston MC, Hodge R. Beta-adrenergic blocker withdrawal syndromes in hypertension and other cardiovascular diseases. Am Heart J. 1988;116:515-523.
32. Higgitt A, Fonagy P, Toone B, Shine P. The prolonged benzodiazepine withdrawal syndrome: anxiety or hysteria. Acta Psychiatr Scand. 1990;82:165-168.
33. Rickels K, Case WG, Schweizer E, Garcia-Espana F, Fridman R. Benzodiazepine dependence: management of discontinuation. Psychopharmacol Bull. 1990;26: 63-68.
34. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-245.
35. Burke LB, Jolson HM, Goetsch RA, Ahronheim JC. Geriatric drug use and adverse drug events reporting in 1991 : a descriptive analysts of two national data bases. Ann Rev Gerontol Geriatr. 1992;12:1-28.
36. International Classification of Diseases, Ninth Revision, Classification Modification. 3rd ed. Washington, DC: Practice Management Information Corp; 1989.
37. Veterans Affairs Medication Classification System. In: USP DI. Rockville, Md: The United States Pharmacopeial Convention Inc; 1990:appendix VI.
38. Hutchinson TA, Flegel KM, Kramer MS, Leduc DG, Kong HH. Frequency, severity, and risk factors for adverse drug reactions in adult out-patients: a prospective study. J Chronic Dis. 1986;39:533-542.
39. Hosmer D, Lemeshow S. Applied Logistic Regression. New York, NY: John Wiley & Sons Inc; 1989.
40. SAS/STAT User's Guide. Gary, NC: SAS Institute Inc; 1993.