Structural requirements for potent Na/H exchange inhibitors obtained from quantitative structure-activity relationships of monocyclic and bicyclic aroylguanidines

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 8, 1997, Pages 1282-1286

  Yamamoto, Takeshi ^a   Hori, Manabu ^a   Watanabe, Ikuo ^a   Tsutsui, Hisayoshi ^a   Harada, Kengo ^a   Ikeda, Shoji ^a   Ohtaka, Hiroshi ^a  

^a KANEBO LTD   (Japan)

Author keywords

Aroylguanidine; Na H exchange inhibitor; Quantitative structure activity relationship; Structural requirement

Indexed keywords

GUANIDINE DERIVATIVE; ION TRANSPORT AFFECTING AGENT; N (3 AMINO 6 CHLORO 5 ETHYLISOPROPYLAMINOPYRAZINE 4 CARBONYL)GUANIDINE; UNCLASSIFIED DRUG; SODIUM PROTON EXCHANGE PROTEIN;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; HYDROPHOBICITY; PROTON SODIUM EXCHANGE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ABDOMINAL AORTA; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; MALE; METABOLISM; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VASCULAR SMOOTH MUSCLE; WISTAR RAT;

ANIMALS; AORTA, ABDOMINAL; CHEMISTRY, PHYSICAL; GUANIDINES; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030764331     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1282     Document Type: Article

References (8)

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