Pyridoxine-5'-β-D-glucoside exhibits incomplete bioavailability as a source of vitamin B-6 and partially inhibits the utilization of co-ingested pyridoxine in humans

Journal of Nutrition

Volumn 127, Issue 8, 1997, Pages 1508-1513

  Nakano, Hideko ^a   McMahon, Laura G ^a   Gregory III, Jesse F ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Bioavailability; Humans; Pyridoxine 5' D glucoside; Stable isotope; Vitamin B 6

Indexed keywords

DEUTERIUM; GLUCOSIDE; PYRIDOXIC ACID; PYRIDOXINE; PYRIDOXINE DERIVATIVE;

ADULT; ARTICLE; BIOAVAILABILITY; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INGESTION; ISOTOPE LABELING; MALE; NORMAL HUMAN; URINARY EXCRETION; VITAMIN INTAKE; VITAMIN METABOLISM;

EID: 0030763914     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.8.1508     Document Type: Article

References (29)

1. Andon, M. B., Reynolds, R. D., Moser-Veillon, P. B. & Howard, M. P. (1989) Dietary intake of total and glycosylated vitamin B-6 and vitamin B-6 nutritional status of unsupplemented lactating women and their infants. Am. J. Clin. Nutr. 50: 1050-1058.
2. Banks, M. A. & Gregory, J. F. (1994) Mice, hamsters, and guinea pigs differ in efficiency of pyridoxine-β-D-glucoside utilization. J. Nutr. 124: 406-414.
3. Banks, M. A., Porter, D. W., Martin, W. G. & Gregory, J. F. (1994) Dietary vitamin B-6 effects on the distribution of intestinal mucosal and microbial β-glucosidase activities toward pyridoxine-β-D-glucoside in the guinea pig. J. Nutr. Biochem. 5: 238-242.
4. Cheng, S. & Trumbo, P. R. (1993) Pyridoxine-5′-β-D-glucoside: metabolic utilization in rats during pregnancy and availability to the fetus. J. Nutr. 123: 1875-1879.
5. Coburn, S. P., Lin, C. C., Schaltenbrand, W. E. & Mahuren, J. D. (1982) Synthesis of deuterated vitamin B-6 compounds. J. Labelled Compd. Radiopharm. 19: 703-716.
6. Coburn, S. P., Mahuren, J. D., Erbelding, W. F., Townsend, D. W., Hachey, D. L. & Klein, P.D. (1984) Measurement of vitamin B-6 kinetics in vivo using chronic administration of labeled pyridoxine. Prog. Clin. Biol. Res. 144A: 43-54.
7. Food and Nutrition Board (1989) Recommended Dietary Allowances, 10th ed. National Academy of Sciences. Washington, DC.
8. Gilbert, J. A & Gregory, J. F. (1992) Pyridoxine-5′-β-D-glucoside affects the metabolic utilization of pyridoxine in rats. J. Nutr. 122: 1029-1035.
9. Gregory, J. F. & Ink, S. L. (1987) Identification and characterization of pyridoxine-β-glucoside as a major form of vitamin B-6 in plant-derived foods. J. Agric. Food Chem. 35: 76-82.
10. Gregory, J. F. & Kirk, J. R. (1977) Improved chromatographic separation and fluorometric determination of vitamin B-6 compounds in foods. J. Food Sci. 42: 1073-1076.
11. Gregory, J. F. & Kirk, J. R. (1979) Determination of urinary 4-pyridoxic acid using high performance liquid chromatography. Am. J. Clin. Nutr. 32: 879-883.
12. Gregory, J. F. & Sartain, D. B. (1991) Improved chromatographic determination of free and glycosylated forms of vitamin B-6 in foods. J. Agric. Food Chem. 39: 899-905.
13. Gregory, J. F., Trumbo, P. R., Bailey, L. B., Toth, J. P., Baumgartner, T. G. & Cerda, J. J. (1991) Bioavailability of pyridoxine-5′-β-D-glucoside determined in humans by stable-isotopic methods. J. Nutr. 121: 177-186.
14. Hachey, D. L., Coburn, S. P., Brown, L. T., Erbelding, W. F., DeMark, B. & Klein, P. D. (1985) Quantitation of vitamin B-6 in biological samples by isotope dilution mass spectrometry. Anal. Biochem. 151: 159-168.
15. Hansen, C. M., Leklem, J. E. & Miller, L. T. (1996) Vitamin B-6 status indicators decrease in women consuming a diet high in pyridoxine glucoside. J. Nutr. 126: 2512-2518.
16. Ink, S. L., Gregory, J. F. & Sartain, D. B. (1986) Determination of pyridoxine-5′-β-D-glucoside bioavailability using intrinsic and extrinsic labeling in the rat. J. Agric. Food Chem. 34: 857-862.
17. Joseph, T., Tsuge, H., Suzuki, Y. & McCormick, D. B. (1996) Pyridoxine 4′-α-and 5′-α-D-glucosides are taken up and metabolized by isolated rat liver cells. J. Nutr. 126: 2899-2903.
18. Kabir, H., Leklem, J. E. & Miller, L. T. (1983) Measurement of glycosylated vitamin B-6 in foods. J. Food Sci. 48: 1422-1425.
19. Kant A. K. & Block, G. (1990) Dietary vitamin B-6 intake and food sources in the US population: NHANES II, 1976-1980. Am. J. Clin. Nutr. 52: 707-716.
20. Nakano, H. & Gregory, J. F. (1995a) Pyridoxine-5′-β-D-glucoside influences the short-term metabolic utilization of pyridoxine in rats. J. Nutr. 125: 926-932.
21. Nakano, H. & Gregory, J. F. (1995b) Pyridoxine and pyrldoxine-5′-β-D-glucoside exert different effects on tissue B-6 vitamers but similar effects on β-glucosidase activity in rats. J. Nutr. 125: 2751-2762.
22. Nakano, H., Levy, M.-D. & Gregory, J.F. (1995) Isolation and properties of pyridoxine-5′-β-D-glucosidase from pig intestinal mucosa. FASEB J. 9: A986 (abs.).
23. Neter, J., Wasserman, W. & Kutner, M. H. (1985) Applied Linear Statistical Models: Regression, Analysis of Variance, and Experimental Designs, 2nd ed. R. D. Irwin, Inc., Homewood, IL.
24. Shultz, T. D. & Leklem, J. M. (1981) Urinary 4-pyridoxic acid, urinary vitamin B-6 and plasma pyridoxal phosphate as measures of vitamin B-6 status and dietary intake in adults. In: Methods in Vitamin B-6 Nutrition (Leklem, J. E. & Reynolds, R. D., eds.), pp. 397-320, Plenum Press, New York, NY.
25. Trumbo, P. R., Banks, M. A. & Gregory, J. F. (1990) Hydrolysis of pyridoxine-5′-β-D-glucoside by a broad-specificity β-glucosidase from mammalian tissues. Proc. Soc. Exp. Biol. Med. 195: 240-246.
26. Trumbo, P. R. & Gregory, J. F. (1988) Metabolic utilization of pyridoxine-5′-β-D-glucoside in rats: influence of vitamin B-6 status and route of administration. J. Nutr. 118: 1336-1342.
27. Trumbo, P. R., Gregory, J. F. & Sartain, D. B. (1988) Incomplete utilization of pyridoxine-β-glucoside as vitamin B-6 in the rat. J. Nutr. 118: 170-175.
28. Tsuge, H., Maeno, M., Hayakawa, T. & Suzuki, Y. (1996) Comparative study of pyridoxine-α,β- glucosides, and phosphopyridoxyl-lysine as a vitamin B-6 nutrient. J. Nutr. Sci. Vitaminol. 42: 377-386.
29. Zhang, Z., Gregory, J. F. & McCormick, D. B. (1993) Pyridoxine-5′-β-D-glucoside competitively inhibits uptake of vitamin B-6 into rat liver cells. J. Nutr. 123: 85-89.