Operator interactions by the Bacillus subtilis arginine repressor/activator, AhrC: Novel positioning and DNA-mediated assembly of a transcriptional activator at catabolic sites

Molecular Microbiology

Volumn 26, Issue 1, 1997, Pages 37-48

  Miller, Coleen M ^a   Baumberg, Simon ^a   Stockley, Peter G ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; REGULATOR PROTEIN;

ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DNA FOOTPRINTING; MOLECULAR INTERACTION; NONHUMAN; OPERATOR GENE; PRIORITY JOURNAL;

EID: 0030763298     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.5441907.x     Document Type: Article

References (36)

1. Baumberg, S., and Klingel, U. (1993) Biosynthesis of arginine, proline, and related compounds. In Bacillus subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics. Sonenshein, A.L., Hoch, J. A., and Losick, R. (eds). Washington, DC: American Society for Microbiology, pp. 299-306.
2. Calogero, S., Gardan, R., Glaser, P., Schweizer, J., Rapoport, G., and Débarbouillé, M. (1994) RocR, a novel regulatory protein controlling arginine utilization in Bacillus subtilis, belongs to the NtrC/NifA family of transcriptional activators. J Bacteriol 176: 1234-1241.
3. Carey, J. (1991) Gel retardation. Methods Enzymol 208: 103-117.
4. 54-dependent promoters on linear templates requires intrinsic or induced bending of the DNA. J Mol Biol 261: 348-356.
5. Chen, S-H., Merican, A.F., and Sherratt, D.J. (1997) DNA binding of Escherichia coli arginine repressor mutants altered in oligomeric state. Mol Microbiol 24: 1143-1156.
6. Collado-Vides, J., Magasanik, B., and Gralla, J.D. (1991) Control site location and transcriptional regulation in Escherichia coli. Microbiol Rev 55: 371-394.
7. Cunin, R., Glansdorff, N., Piérard, A., and Stalon, V. (1986) Biosynthesis and metabolism of arginine in bacteria. Microbiol Rev 50: 314-352.
8. Czaplewski, L.G., North, A.K., Smith, M.C.M., Baumberg, S., and Stockley, P.G. (1992) Purification and initial characterization of AhrC; the regulator of arginine metabolism genes in Bacillus subtilis. Mol Microbiol 6: 267-275.
9. 54 from Gram-negative bacteria. Proc Natl Acad Sci USA 88: 9092-9096.
10. Fried, M. G. (1989) Measurement of protein-DNA interaction parameters by electrophoresis mobility shift assay. Electrophoresis 10: 366-376.
11. Gardan, R., Rapoport, G., and Débarbouillé, M. (1995) Expression of the rocDEF, operon involved in arginine catabolism in Bacillus subtilis. J Mol Biol 249: 843-856.
12. Glansdorff, N. (1987) Biosynthesis of arginine and polyamines. In Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. Neidhardt, F.C. (ed.). Washington, DC: American Society for Microbiology, pp. 321-344.
13. Glaser, P., Kunst, F., Arnaud, M., Coudart, M.-P., Gonzales, W., Hullo, M.-F., Ionescu, M., Lubochinsky, B., Marcelino, L., Moszer, I., Presecan, E., Santana, M., Schneider, E., Schweizer, J., Vertes, A., Rapoport, G., Danchin, A. (1993) Bacillus subtilis genome project cloning and sequencing of the 97 kb region from 325′ to 333′. Mol Microbiol 10: 371-384.
14. Grandori, R., Lavoie, T.A., Pflumm, M., Tian, G., Niersbach, H., Maas, W.K., Fairman, R., and Carey, J. (1995) The DNA-binding domain of the hexameric arginine repressor. J Mol Biol 254: 150-162.
15. Guhathakurta, A., Viney, L., and Summers, D. (1996) Accessory proteins impose site selectivity during CoIEI dimer resolution. Mol Microbiol 20: 613-620.
16. Harwood, C.R., and Baumberg, S. (1977) Arginine hydroxamate-resistant mutants of Bacillus subtilis with altered control of arginine metabolism. J Gen Microbiol 100: 177-188.
17. Harwood, C.R., and Cutting, S.M. (1990) Molecular Biological Methods for Bacillus. Chichester: John Wiley & Sons.
18. Kim, J., Zwieb, C., Wu, C., and Adhya, S (1989) Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector. Gene 85: 15-23.
19. Klingel, U., Miller, C.M., North, A.K., Stockley, P.G., and Baumberg, S. (1995) A binding site for activation by the Bacillus subtilis AhrC protein, a repressor/activator of arginine metabolism. Mol Gen Genet 248: 329-340.
20. Lim, D.B., Oppenheim, J.D., Eckhardt, T., and Maas, W.K. (1987) Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor. Proc Natl Acad Sci USA 84: 6697-6701.
21. Maas, W.K. (1994) The arginine repressor of Escherichia coli. Microbiol Rev 58: 631-640.
22. Miller, C.M. (1996) Mechanism and function of the Bacillus subtilis arginine regulatory protein, AhrC. PhD thesis, University of Leeds.
23. Mountain, A., and Baumberg, S (1980) Map locations of some mutations conferring resistance to arginine hydroxamate in Bacillus subtilis 168. Mol Gen Genet 178: 691-701.
24. North, A.K., Smith, M.C.M., and Baumberg, S. (1989) Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor. Gene 80: 29-38.
25. Oehler, S., Eismann, E.R., Krämer, H., and Müller-Hill, B. (1990) The three operators of the lac operon cooperate in repression. EMBO J 9: 973-979.
26. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
27. Schägger, H., and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166: 368-379.
28. Smith, M.C.M., Mountain, A., and Baumberg, S. (1986a) Cloning in Escherichia coli of a Bacillus subtilis arginine repressor gene through its ability to confer structural stability on a fragment carrying genes of arginine biosynthesis. Mol Gen Genet 205: 176-182.
29. Smith, M.C.M., Mountain, A., and Baumberg, S. (1986b) Sequence analysis of the Bacillus subtilis argC promoter region. Gene 49: 5 3-60.
30. Smith, M.C.M., Czaplewski, L., North, A.K., Baumberg, S., and Stockley, P.G. (1989) Sequences required for regulation of arginine biosynthesis promoters are conserved between Bacillus subtilis and Escherichia coli. Mol Microbiol 3: 23-28.
31. Stirling, C.J., Szatmari, G., Stewart, G., Smith, M.C.M., and Sherratt, D.J. (1988) The arginine repressor is essential for plasmid-stabilizing site-specific recombination at the ColEl cer locus. EMBO J 7: 4389-4395.
32. Thompson, J.F., and Landy, A. (1988) Empirical estimation of protein-induced DNA bending angles-applications to λ site-specific recombination complexes. Nucleic Acids Res 20: 9687-9705.
33. Tian, G., and Maas, W.K. (1994) Mutational analysis of the arginine repressor of Escherichia coli. Mol Microbiol 13: 599-608.
34. Tian, G., Lim, D., Carey, J., and Maas, W.K. (1992) Binding of the arginine repressor of Escherichia coli K-12 to its operator sites. J Mol Biol 226: 387-397.
35. Tian, G., Lim, D., Oppenheim, J.D., and Maas, W.K. (1994) Explanation for different types of regulation of arginine biosynthesis in Escherichia coli B and Escherichia coli K-12 caused by a difference between their arginine repressors. J Mol Biol 235: 221-230.
36. Van Duyne, G.D., Ghosh, G., Maas, W.K., and Sigler, P.B. (1996) Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. J Mol Biol 256: 377-391.