Daily fluoxetine administration impairs avoidance learning in the rat without altering sensory thresholds

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 6, 1997, Pages 1043-1057

  Nelson, Christina J ^a,b   Jordan, Wesley P ^a   Bohan, Rose T ^a  

^a ST MARY'S COLLEGE OF MARYLAND   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

Avoidance learning; Escape learning; Fluoxetine; Rats

Indexed keywords

FLUOXETINE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PERCEPTIVE THRESHOLD; RAT;

ANALGESIA; ANIMALS; AVOIDANCE LEARNING; ELECTROSHOCK; ESCAPE REACTION; FLUOXETINE; HEAT; MALE; MOTIVATION; MOTOR ACTIVITY; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030762879     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(97)00097-3     Document Type: Article

References (32)

1. ARCHER, T., ÖGREN, S., JOHANSSON, G., and ROSS, S. (1984) The effect of acute zimelidine and alaproclate administration on the acquisition of two-way active avoidance: Comparison with other antidepressant agents, tests of selectivity and sub-chronic studies. Psychopharmacology 84: 188-195.
2. BRAIN, P., and AL-HAZMI, M. A. (1991) Studies of the effects of ethyl alcohol on rodent behavior in diverse tests. In T. Archer and S. Hansen (Eds.) Behavioral biology: Neuroendocrine axis. Hillsdale, NJ: Erlbaum.
3. CALLAWAY, C., WING, L., NICHOLS, D. and GEYER, M. (1993) Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release. Psychopharmacology 111: 169-178.
4. COX, B. J., SWINSON, R. P., MORRISON, B., and LEE, P. S. (1993) Clomipramine, fluoxetine, and behavior therapy in the treatment of obsessive-compulsive disorder: A meta-analysis. J Behav Ther and Exp Psychiat 24: 149-153.
5. DURCAN, M. J., LISTER, R. G., ECKARDT, M. J., and LINNOILA, M. (1988). Behavioral interactions of fluoxetine and other 5-hydroxytryptamine uptake inhibitors with ethanol in tests of anxiety, locomotion, and exploration. Psychopharmacol 96: 528-533.
6. DAVIS, M. (1979) Diazepam and flurazepam: Effects on conditioned fear as measured with the potentiated startle effect. Psychopharmacology 61: 1-7.
7. FLOOD, J. F., and CHERKIN, A. (1987). Fluoxetine enhances memory processing in mice. Psychopharmacol 93: 36-43.
8. GEBHART, M., and LORENS, S. (1980) Attenuation of pethidine-induced antinociception by zimelidine, an inhibitor of 5-hydroxytryptamine reuptake. Br J Pharmacol 70: 411-414.
9. GEOFFROY, M., SCHEEL-KRÜGER, J., and CHRISTENSEN, A. (1990) Effect of imipramine in the "learned helplessness" model of depression in rats is not mimicked by combinations of specific reuptake inhibitors and scopolamine. Psychopharmacology 101: 371-375.
10. HANDLEY, S. (1995). 5-hydroxytryptamine pathways in anxiety and its treatment. Pharmac Ther 66: 103-148.
11. HARVEY, J., and SIMANSKY, K. (1979) The role of serotonin in modulation of nociceptive reflexes. In B. H. Haber, S. Gabay, M. R. Issidorides, and S. G. A. Alivisatos (Eds.) Serotonin: Currents aspects of neurochemistry and function. New York: Plenum.
12. HOEHN-SARIC, R., LIPSEY, J., and MCLEOD, D. (1990) Apathy and indifference in patients on fluvoxamine and fluoxetine. J Clin Psychopharmacol 10: 343-345.
13. HYNES, M., LOCHNER, M., BEMIS, K., and HYMSON, D. (1985) Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors. Life Sci 36: 2317-2323.
14. INTROINI-COLLISON, I., TO, S., and MCGAUGH, J. (1992) Fluoxetine effects on retention of inhibitory avoidance: Enhancement by systemic but not intra-amygdala injections. Psychobiology 20: 28-32.
15. JOLY, D., and SANGER, D. J. (1986) The effects of fluoxetine and zimelidine on the behavior of olfactory bulbectomized rats. Pharmacol Biochem Behav 24: 199-204.
16. LIN, M., CHANDRA, A., CHI, M., and KAU, C. (1980) Effects of increasing serotonergic receptor activity in brain on analgesic activity in rats. Exp Neurol 68: 548-554.
17. 1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior. J Pharmacol Exp Ther 250: 60-70.
18. MARTIN, P., PICHAT, P., MASSOL, J., SOUBRIE, P., LLOYD, K., and PUECH, A. (1982) Decreased GABA B receptors in helpless rats: Reversal by tricyclic antidepressants. Pharmacol Biochem Behav 16: 449-454.
19. MARTIN, P., SOUBRIE, P., and PUECH, A. (1990) Reversal of helpless behavior by serotonin uptake blockers in rats. Psychopharmacology 101:403-407.
20. MARTIN, P., SOUBRIE, P., and SIMON, P. (1987) The effect of mono-amine oxidase inhibitors compared with classical tricyclic antidepressants on learned helplessness paradigm. Prog Neuro-psychopharmacol and Biol Psychiat 11: 1-7.
21. MASSOL, J., MARTIN, P., and PUECH, A. (1989) Antidepressant effects of tricyclic antidepressants and selective serotonin-uptake blockers in diabetic rats. Diabetes 38: 1161-1164.
22. MCELROY, J., DUPONT, A., and FELDMAN, R. (1982) The effects of fenfluramine and Fluoxetine on the acquisition of a conditioned avoidance response in rats. Psychopharmacology 77: 356-359.
23. MENESES, A., and HONG, E. (1995) Effect of fluoxetine on learning and memory involves multiple 5-HT systems. Pharmacol Biochem Behav 52: 341-346.
24. MESSING, R., FISHER, L., PHEBUS, L., and LYTLE, L. (1976) Interaction of diet and drugs in the regulation of brain 5-hydroxyindoles and the response to painful electric shock. Life Sci 18: 707-714.
25. OVERMIER, J., and SELIGMAN, M. (1967) Effects of inescapable shock upon subsequent escape and avoidance responding. J Comp Physiol Psychol 63: 28-33.
26. PETERSON, C., MAIER, S., and SELIGMAN, M. (1993) Learned helplessness: A theory for the age of personal control. New York: Oxford University Press.
27. PRESKORN, S. (1994). Targeted pharmacotherapy in depression management: comparative pharmacokinetics of fluoxetine, paraxetine and sertraline. Internat Clin Psychopharmacol 9 Suppl 3: 13-19.
28. RAY, O., and KSIR, C. (1996) Drugs, society, and human behavior. New York: Mosby.
29. SEIDEN, L., DAHMS, J., and SHAUGHNESSY, R. (1985) Behavioral screen for antidepressants: The effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule. Psychopharmacology 86: 55-60.
30. SHERMAN, A.D., SACQUITNE, J. L., and PETTY, F. (1989) Specificity of the learned helplessness model of depression. Neuropsychobiology 22: 220-224.
31. TOLLEFSON, G. D., HOLMAN, S. L., SAYLER, M. E., and POTVIN, J. H. (1994) Fluoxetine, placebo, and tricyclic antidepressants in major depression with and without anxious features. J Clin Psychiat 55: 50-59.
32. WILLNER, P. (1984) The validity of animal models of depression. Psychopharmacology 83: 1-16.