Specific Inhibitors of aminopeptidase P: Peptides and pseudopeptides of 2-hydroxy-3-amino acids

Advances in Experimental Medicine and Biology

Volumn 421, Issue , 1997, Pages 31-35

  Stöckel, Angela ^a   Stiebitz, Beate ^a   Neubert, Klaus ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE P; ENZYME INHIBITOR; PSEUDOPEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROLYSIS; INHIBITION KINETICS; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030762840     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9613-1_5     Document Type: Article

References (9)

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2. Simmons, W. H. and Orawski, A. T.: Membrane-bound Aminopeptidase P from Bovine Lung. J. Biol. Chem. 267: 4897-4903, 1992.
3. Prechel, M. M., Orawski, A. T., Maggiora, L. L. and Simmons, W. H.: Effect of a New Aminopeptidase P Inhibitor, Apstatin, on Bradykinin Degradation in the Rat Lung. J. Pharmacol. Exp. Ther. 275:1136-1142, 1995.
4. Rich, D. H., Moon, B. J. and Harbeson, S.: Inhibition of Aminopeptidases by Amastatin and Bestatin Derivates. Effect of Inhibitor Structure on Slow-Binding Processes. J. Med. Chem. 27: 417-422, 1984.
5. Burley, S. K., David, P. R. and Lipscomb, W. N.: Leucine Aminopeptidase: Bestatin Inhibition and a Model for Enzyme-Catalyzed Peptide Hydrolysis. Proc. Natl. Acad. Sci. USA. 88: 6916-6920, 1991.
6. Herranz, R., Castro-Pichel, J., Vinuesa, S. and Garcia-Lopez, M. T.: An Improved One-Pot Method for the Stereoselective Synthesis of the (2S,3R)-3-Amino-2-hydroxy Acids: Key Intermediates for Bestatin and Amastatin. J. Org. Chem. 55:2232-2234, 1990.
7. Stiebitz, B., Stöckel, A., Lasch, J. and Neubert, K.: Development of a Continuous Assay for Aminopeptidase P: Substrate Design and Substrate Specificity. Symposium: Cellular Peptidases in Immune Functions and Diseases: poster - abstract. Magdeburg, 1996.
8. Segel, I. H.: Enzyme Kinetics. p. 170-178, John Wiley & Sons, Inc., New York, 1993.
9. Yoshimoto, T., Orawski, A. T. and Simmons, W. H.: Substrate Specifity of Aminopeptidase P from Escherichia coli: Comparison with Membrane-Bound Forms from Rat and Bovine Lung. Arch. Biochem. Biophys. 311:28-34, 1994.