N-glycosylation is not essential for enzyme activity of 11β- hydroxysteroid dehydrogenase type 2

Kidney International

Volumn 52, Issue 3, 1997, Pages 682-686

  Kyossev, Zhetcho N ^a   Reeves, W Brian ^a,b  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

11 hydrozysteroid dehydrogenase; Aldosterone; Colon; Glycosylation; Kidney; Mutagenesis; N glycosylation

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; CORTISONE; DEHYDROCORTICOSTERONE; HYDROCORTISONE; MINERALOCORTICOID; TUNICAMYCIN;

ANIMAL CELL; ARTICLE; CHO CELL; COLON MUCOSA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

EID: 0030762211     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.382     Document Type: Article

References (22)

1. JORNVALL H, PERSSON B, KROOK M, ATRIAN S, GONZALEZ-DUARTE R, JEFFERY J, GHOSH D: Short-chain dehydrogenases/reductases (SDR). Biochemistry 34:6003-6013, 1995
2. FUNDER JW, PEARCE PT, SMITH R, SMITH AI: Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science 242:583-585, 1988
3. LAKSHMI V, MONDER C: Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex. Endocrinology 123: 2390-2398, 1988
4. RUSVAI E, NARAY-FEJES-TOTH A: A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells. J Biol Chem 268: 10717-10720, 1993
5. REEVES WB: NAD-dependent 11β-hydroxysteroid dehydrogenase in cultured human colonic epithelial cells. Am J Physiol 268:C1467-C1473, 1995
6. AGARWAL AK, MONDER C, ECKSTEIN B, WHITE PC: Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. J Biol Chem 264:18939-18943, 1989
7. ALBISTON AL, OBEYESEKERE VR, SMITH RE, KROZOWSKI ZS: Cloning and distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrin 105:R11-R17, 1994
8. ZHOU M-Y, GOMEZ-SANCHEZ EP, COX DL, COSBY D, GOMEZ-SANCHEZ CE: Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11β-hydroxysteroid dehydrogenase. Endocrinology 136:3729-3734, 1995
9. COLE, TJ: Cloning of the mouse 11β-hydroxysteroid dehydrogenase type 2 gene: Tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney. Endocrinology 136:4693-4696, 1995
10. AGARWAL AK, MUNE T, MONDER C, WHITE PC: NAD-dependent isoform of 11β-hydroxysteroid dehydrogenase. J Biol Chem 269: 25959-25962, 1994
11. NARAY-FEJES-TOTH A, FEJES-TOTH G: Expression cloning of the aldosterone target cell-specific 11β-hydroxysteroid dehydrogenase from rabbit collecting duct cells. Endocrinology 136:2579-2568, 1995
12. KROZOWSKI Z, MAGUIRE JA, STEIN-OAKLEY AN, DOWLING J, SMITH RE, ANDREWS RK: Immunohistochemical localization of the 11β-hydroxysteroid dehydrogenase Type II enzyme in human kidney and placenta. J Clin Endocrinol Metab 80:2203-2209, 1995
13. KYOSSEV Z, WALKER PD, REEVES WB: Immunolocalization of NAD-dependent 11β-hydroxysteroid dehydrogenase in human kidney and colon. Kidney Int 49:271-281, 1996
14. WHORWOOD CB, RICKETTS ML, STEWART PM: Epithelial cell localization of Type 2 11β-hydroxysteroid dehydrogenase in rat and human colon. Endocrinology 135:2533-2541, 1994
15. NIKKILA H, TANNIN GM, NEW MI, TAYLOR NF, KALAITZOGLOU G, MONDER C, WHITE PC: Defects in the HSD11 gene encoding 11β-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency. J Clin Endocrinol Metabol 77:687-691, 1993
16. WILSON RC, KROZOWSKI ZS, LI K, OBEYESEKERE VR, RAZZAGHY-AZAR M, HARBIXON MD, WEI JQ, SHACKLETON CHL, FUNDER JW, NEW MI: A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess. J Clin Endocrinol Metabol 80:2263-2266, 1995
17. MUNE T, ROGERSON FM, NIKKILA H, AGARWAL AK, WHITE PC: Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nature Genet 10:394-399, 1995
18. STEWART PM, KROZOWSKI ZS, GUPTA A, MILFORD DV, HOWIE AJ, SHEPPARD MC, WHORWOOD CB: Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene. Lancet 347:88-91, 1996
19. AGARWAL AK, MUNE T, MONDER C, WHITE PC: Mutations in putative glycosylation sites of rat 11β-hydroxysteroid dehydrogenase affect enzymatic activity. Biochim Biophys Acta 1248:70-74, 1995
20. NARAY-FEJES-TOTH A, FEJES-TOTH G: Subcellular localization of the type 2 11β-hydroxysteroid dehydrogenase. J Biol Chem 271:26, 15436-15442, 1996
21. TKACZ JC, LAMPEN JP: Tunicamycin inhibition of polyisoprenyl-n-acetylglucosaminyl pyrophosphate formation in calf-liver-microsomes. Biochem Biophys Res Commun 65:248-257, 1975
22. BROWN RW, CHAPMAN KE, MURAD P, EDWARDS CRW, SECKL JR: Purification of 11β-hydroxysteroid dehydrogenase type 2 from human placenta utilizing a novel affinity labelling technique. Biochem J 313:997-1005, 1996