Gentamicin inhibits rat renal cortical homotypic endosomal fusion: Role of megalin

American Journal of Physiology - Renal Physiology

Volumn 272, Issue 1 41-1, 1997, Pages

  Hammond, Timothy G ^a,b   Majewski, Rebecca R ^b   Kaysen, James H ^a   Goda, Fatima O ^a   Navar, Gabriel L ^a   Pontillon, Francoise ^c   Verroust, Pierre J ^c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Wisconsin Health   (United States)

^c HÔPITAL TENON   (France)

Author keywords

Drug toxicity; Flow cytometry; Peptide; Receptor

Indexed keywords

GENTAMICIN; GLYCOPROTEIN;

ANIMAL TISSUE; ARTICLE; CELL VACUOLE; DRUG RECEPTOR BINDING; ENDOSOME; FLOW CYTOMETRY; KIDNEY CORTEX; MALE; NEPHROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0030761241     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.272.1.f117     Document Type: Article

References (27)

1. Banks, B. C. Trough levels of gentamicin do not indicate tissue accumulation. Biochem. Soc. Trans. 19: 128s, 1991.
2. Beauchamp, D., P. Gourde, and M. G. Bergeron. Subcellular distribution of gentamicin in proximal tubular cells determined by immunogold labeling. Antimicrob. Agents Chemother. 35: 2173-2179, 1991.
3. Beauchamp, D., G. Laurent, P. Maldague, S. Abid, B. K. Kishore, and P. M. Tulkens. Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by coadministration of poly-L-aspartic acid. J. Pharmacol. Exp. Ther. 255: 858-866, 1990.
4. Bennett, M. K., and R. H. Scheller. The molecular machinery for secretion is conserved from yeast to neurons. Proc. Natl. Acad. Sci. USA 90: 2559, 1993.
5. Bennett, W. M. Aminoglycoside nephrotoxicity. Nephron 35: 73-77, 1983.
6. Braell, W. A. Fusion between endocytic vesicles in a cell-free system. Proc. Natl. Acad. Sci. USA 84: 1137-1141, 1987.
7. De Broe, M. E., G. J. Paulus, G. A. Verpooten, F. Roels, N. Buyssens, R. Wedeen, F. van Hoof, and P. M. Tulkens. Early effects of gentamicin, tobramycin and amikacin on the human kidney. Kidney Int. 25: 643-652, 1984.
8. Golbert, D. N., C. A. Wood, S. J. Kohlhepp, P. W. Kohnen, D. C. Houghton, H. C. Finkbeiner, J. Lindsley, and W. M. Bennett. Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity. J. Infect. Dis. 159: 945-953, 1989.
9. Gruenberg, J. E., and K. E. Howell. Reconstitution of vesicle fusions occurring in endocytosis with a cell-free system. EMBO J. 5: 3091-3101, 1986.
10. Hammond, T. G., R. R. Majewski, D. J. Morre, K. Schell, and L. W. Morrissey. Forward scatter pulse width signals resolve multiple populations of endosomes. Cytometry 14: 411-420, 1993.
11. Hammond, T. G., R. R. Majewski, K. E. Muse, T. D. Oberley, L. W. Morrissey, and A. M. Amendt-Raduege. Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F1021-F1033, 1994.
12. Hammond, T. G., P. J. Verroust, R. R. Majewski, K. E. Muse, and T. D. Oberley. Heavy endosomes isolated from the rat renal cortex have attributes of intermicrovillar clefts. Am. J. Physiol. 267 (Renal Fluid Electrolyte Physiol. 36): F516-F527, 1994.
13. Jo, I., H. W. Harris, Jr., A. M. Amendt-Raduege, R. R. Majewski, and T. G. Hammond. Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of anti-diuretic hormone (ADH) water channel-containing endosomes in vitro. Proc. Natl. Acad. Sci. USA 92: 1876-1880, 1995.
14. Kishore, B. K., Z. Kallay, P. Lambright, G. Laurent, and P. M. Tulkens. Mechanism of protection afforded by polyaspartic acid against gentamicin induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro. J. Pharmacol. Exp. Ther. 255: 867-874, 1990.
15. Laurent, G., G. Toubeau, J. A. Heuson-Stiennon, P. M. Tulkens, and P. Maldague. Kidney tissue repair after nephrotoxic injury: biochemical and morphological characterization. CRC Crit. Rev. Toxicol. 19: 147-183, 1988.
16. Matter, K., E. M. Yamamoto, and I. Mellman. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells. J. Cell Biol. 126: 991-1004, 1994.
17. Moestrup, S. K. The α2-macroglobulin receptor and epithelial glycoprotein 330: Two giant receptors mediating endocytosis of multiple ligands. Biochim. Biophys. Acta 1197: 197-213, 1994.
18. Moestrup, S. K., S. Cui, H. Vorum, C. Bregengaard, S. E. Bjoørn, K. Norris, J. Gliemann, and E. I. Christensen. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 96: 1404-1413, 1995.
19. Nishimoto, I. The IGF-II receptor system: a G protein-linked mechanism. Mol. Reprod. Dev. 35: 398-407, 1993.
20. Raychowdhury, R., J. L. Niles, R. T. McCluskey, and J. A. Smith. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science Wash. DC 244: 1163-1165, 1989.
21. Rothman, J. E., and G. Warren. Implications of the SNARE hypothesis for intracellular membrane topology and dynamics. Curr. Biol. 4: 220-233, 1994.
22. Sahali, D., N. Mulliez, F. Chatelet, C. Laurentwinter, D. Citadelle, J. C. Sabourin, C. Roux, P. Ronco, and P. J. Verroust. Comparative immunochemistry and ontogeny of two closely related coated pit proteins: the 280kd target of teratogenic antibodies and the 330-kd target of nephritogenic antibodies. Am. J. Pathol. 142: 1654-1667, 1993.
23. Saito, A., S. Pietromonaco, A. K.-C. Loo, and M. G. Farquhar. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA 91: 9725-9729, 1994.
24. Wagner, M. C., B. Barylko, and J. P. Albanesi. Tissue distribution and subcellular localization of mammalian myosin I. J. Cell Biol. 119: 163-170, 1992.
25. Wedeen, R. P., V. Batuman, C. Cheeks, E. Marquet, and H. Sobel. Transport of gentamicin in rat proximal tubule. Lab. Invest. 48: 212-223, 1983.
26. Yamamoto, T., C. G. Davis, M. S. Brown, W. J. Schneider, M. L. Casey, J. L. Goldstein, and D. W. Russell. The human LDL receptor: a cysteine rich protein with multiple Alu sequences in its mRNA. Cell 39: 27-38, 1984.
27. Young, I. T. Proof without prejudice: use of the Kolgomorov-Smirnov test for the analysis of histograms from flow systems and other sources. J. Histochem. Cytochem. 25: 935-941, 1977.