Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron

Hepatology

Volumn 26, Issue 3, 1997, Pages 691-698

  Trinder, Deborah ^a   Morgan, Evan ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; FERRIC CITRATE FE 59; IRON BINDING PROTEIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOCYTOSIS; EXPRESSION VECTOR; HEPATOMA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; IRON TRANSPORT; MICHAELIS CONSTANT; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0030761075     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260322     Document Type: Article

References (29)

1. Baker E, Morgan EH. Iron transport. In: Brock JH, Halliday JJ, Pippard M, Powell L, eds. Iron Metabolism in Health and Disease. London: Saunders, 1994:63-95.
2. Owen D, Kuhn LC. Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron. EMBO J 1987;6:1287-1293.
3. Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: The control of cellular iron metabolism. Cell 1993;72:19-28.
4. Page MA, Morgan EH, Baker E. Transferrin binding and iron uptake by rat hepatocytes in culture. Am J Physiol 1984;246:G26-G33.
5. Trinder D, Zak O, Aisen P. Transferrin receptor independent uptake of diferric transferrin by human hepatoma cells with antisense inhibition of receptor expression. HEPATOLOGY 1996;23:1512-1520.
6. Richardson D, Baker E. Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate. J Biol Chem 1992;267:13972-13979.
7. Chan RYY, Ponka P, Schulman HM. Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells. Exp Cell Res 1992;202:326-336.
8. Trinder D, Morgan E, Baker E. The effects of an antibody to the rat transferrin receptor and of serum albumin on the uptake of diferric transferrin by rat hepatocytes. Biochim Biophys Acta 1988;943:440-446.
9. Zak O, Trinder D, Aisen P. Primary receptor-recognition site of human transferrin is in the C-terminal lobe. J Biol Chem 1994;269:7110-7114.
10. Thorstensen K, Trinder D, Zak O, Aisen P. Uptake of iron from N-terminal half-transferrin by isolated rat hepatocytes: evidence of transferrin receptor-independent iron uptake. Eur J Biochem 1995;232:129-133.
11. Hershko C, Graham G, Bates GW, Rachmilewitz EA. Non specific serum iron in thalassemia: An abnormal serum iron fraction of potential toxicity. Br J Haematol 1978;50:255-263.
12. Batey RG, Lai Chung Fong P, Shamir S, Sherlock S. A non-transferrin bound serum iron in idiopathic hemochromatosis. Dig Dis Sci 1980; 25:340-346.
13. Grootveld M, Bell JD, Halliwell B, Aruoma OI, Bomford A, Sadlier PJ. Non-transferrin bound iron in plasma or serum from patients with idiopathic hemochromatosis. J Biol Chem 1989;264:4417-4422.
14. Craven CM, Alexander J, Eldridge JP, Kushner S, Bernstein S, Kaplan J. Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis. Proc Natl Acad Sci U S A 1987;84:3457-3461.
15. Wright TL, Brissot P, Ma W-L, Weisiger RA. Characterization of non-transferrin-bound iron clearance by rat liver. J Biol Chem 1986;261: 10909-10914.
16. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cell line with differentiated functions in chemically defined medium. Cancer Res 1982;42:3858-3863.
17. Sasaki K, Zak O, Aisen P. Antisense suppression of transferrin receptor gene expression in a human hepatoma cell (HuH-7) line. Am J Hematol 1993;42:74-80.
18. Kuhn LC, McCelland A, Ruddle FH. Gene transfer, expression, and molecular cloning of the human transferrin receptor gene. Cell 1984; 37:95-103.
19. Macfarlane AS. In vivo behavior of 131-fibrinogen. J Clin Invest 1963; 42:346-361.
20. Trinder D, Morgan E, Baker E. The mechanism of iron uptake by fetal rat hepatocytes in culture. HEPATOLOGY 1986;6:852-858.
21. Ghosh RN, Maxfield FR. Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HepG2 cells. J Cell Biol 1995;128:549-561.
22. Thorstensen K. Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin. J Biol Chem 1988;263: 16837-16841.
23. Morgan EH. Membrane transport of non-transferrin iron by reticulocytes. Biochim Biophys Acta 1988;943:428-439.
24. Scheiber B, Goldenberg H. Uptake of iron by isolated rat hepatocytes from a hydrophilic impermeant ferric chelate, Fe(III)-DPTA. Archive Biochem Biophys 1996;326:185-192.
25. Cole ES, Glass J. Transferrin binding and iron uptake in mouse hepatocytes. Biochim Biophys Acta 1983;762:102-110.
26. Wong A. "The effect of iron chelators on hepatocyte iron metabolism." 1995: PhD Thesis. University of Western Australia: Perth, Western Australia.
27. Low H, Sun IL, Navas P, Grebing C, Crane FL, Morre DJ. Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system. Biochim Biophys Res Commun 1986;139:1117-1123.
28. Thorstensen K, Romslo I. Uptake of iron from transferrin by isolated rat hepatocytes: a redox-mediated plasma membrane process. J Biol Chem 1988;263:8844-8850
29. Thorstensen K, Aisen P. Release of iron from diferric transferrin in the presence of rat liver plasma membranes: no evidence of a plasma membrane diferric transferrin reductase. Biochim Biophys Acta 1990; 1052:29-55.