Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes

Infection and Immunity

Volumn 65, Issue 8, 1997, Pages 3430-3437

  Charoenvit, Yupin ^a   Fallarme, Victoria ^a   Rogers, William O ^a   Sacci Jr , John B ^a,b   Kaur, Manjit ^a   Aguiar, Joao Carlos ^a,c   Yuan, Leo F ^a   Corradin, Giampietro ^d   Andersen, Ellen ^e   Wizel, Benjamin ^a,h   Houghten, Richard A ^f   Oloo, Aggrey ^g   De La Vega, Patricia ^a   Huffman, Stephen L ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c PAN AMERICAN HEALTH ORGANIZATION   (United States)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^f TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^g KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^h UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MALARIA VACCINE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PARASITE ANTIGEN; SPOROZOITE VACCINE;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; IMMUNIZATION; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPOROZOITE; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030760780     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.8.3430-3437.1997     Document Type: Article

References (40)

1. Aidoo, M., A. Lalvani, C. E. M. Allsopp, M. Plebanski, S. J. Meisner, P. Krausa, M. Browning, S. Morris-Jones, F. Gotch, and D. A. Fidock, et al. 1995. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria. Lancet 345:1003-1007.
2. Ak, M., J. H. Bower, S. L. Hoffman, M. Sedegah, A. Lees, M. Carter, R. L. Beaudoin, and Y. Charoenvit. 1993. Monoclonal antibodies of three different immunoglobulin G isotypes produced by immunization with a synthetic peptide or native protein protect mice against challenge with Plasmodium yoelii sporozoites. Infect. Immun. 61:2493-2497.
3. 4)β1-Cer] and cholesterol3-sulfate and its dependence on disulfide bond formation between cysteines in region II. Mol. Biochem. Parasitol. 54:1-12.
4. Charoenvit, Y., W. E. Collins, T. R. Jones, P. Millet, L. Yuan, G. H. Campbell, R. L. Beaudoin, J. R. Broderson, and S. L. Hoffman. 1991. Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence. Science 251:668-671.
5. Charoenvit, Y., M. F. Leef, L. F. Yuan, M. Sedegah, and R. L. Beaudoin. 1987. Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens. Infect. Immun. 55:604-608.
6. Cowan, G., S. Krishna, A. Crisanti, and K. Robson. 1992. Expression of thrombospondin-related anonymous protein in Plasmodium falciparum sporozoites. Lancet 339:1412-1413.
7. Dame, J. B., J. L. Williams, T. F. McCutchan, J. L. Weber, R. A. Wirtz, W. T. Hockmeyer, W. L. Maloy, J. D. Haynes, I. Schneider, D. Roberts, G. S. Sanders, E. P. Reddy, C. L. Diggs, and L. H. Miller. 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593-599.
8. Ey, P. L., S. J. Prowse, and C. R. Jenkin. 1978. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose. Immunochemistry 15:429-436.
9. Geysen, H. M., R. H. Meloen, and S. J. Barteling. 1984. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. USA 81:3998-4002.
10. Hedstrom, R. C., J. R. Campbell, M. L. Leef, Y. Charoenvit, M. Carter, M. Sedegah, R. L. Beaudoin, and S. L. Hoffman. 1990. A malaria sporozoite surface antigen distinct from the circumsporozoite protein. Bull. W. H. O. 68(Suppl.):152-157.
11. Hoffman, S. L., E. D. Franke, M. R. Hollingdale, and P. Druilhe. 1996. Attacking the infected hepatocyte, p. 35-75. In S. L. Hoffman (ed.), Malaria vaccine development: a multi-immune response approach. American Society for Microbiology, Washington, D.C.
12. Hollingdale, M. R., E. H. Nardin, S. Tharavanij, A. L. Schwartz, and R. S. Nussenzweig. 1984. Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; and in vitro assay of protective antibodies. J. Immunol. 132:909-913.
13. Houghten, R. A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82:5131-5135.
14. 13a.Institute of Laboratory Animal Resources. 1996. Guide for the care and use of laboratory animals. Institute of Laboratory Animal Resources, National Research Council, National Academy Press, Washington, D.C.
15. Khusmith, S., Y. Charoenvit, S. Kumar, M. Sedegah, R. L. Beaudoin, and S. L. Hoffmam. 1991. Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein. Science 252:715-718.
16. Khusmith, S., M. Sedegah, and S. L. Huffman. 1994. Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2. Infect. Immun. 62:2979-2983.
17. Lee, J. O., P. Rieu, M. Amin Arnaout, and R. Liddington. 1995. Crystal structure of the A domain from the α-subunit of integrin CR3 (CD11b/ CD18). Cell 80:631-638.
18. Mazier, D., S. Mellouk, R. L. Beaudoin, B. Texier, P. Druilhe, W. Hockmeyer, J. Trosper, C. Paul, Y. Charoenvit, J. Young, F. Miltgen, L. Chedid, J. P. Chigot, B. Galley, O. Brandicourt, and M. Gentilini. 1986. Effect of antibodies to recombinant and synthetic peptides on Plasmodium falciparum sporozoites in vitro. Science 231:156-159.
19. Mellouk, S., N. Berbiguier, P. Druilhe, M. Sedegah, B. Galey, L. Yuan, M. Leef, Y. Charoenvit, C. Paul, S. L. Huffman, and R. Beaudoin. 1990. Evaluation of an in vitro assay aimed at measuring protective antibodies against sporozoites. Bull. W. H. O. 68(Suppl.):52-59.
20. Merrifield, R. B. 1963. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85:2149-2153.
21. Muller, H. M., I. Reckmann, M. R. Hollingdale, H. Bujard, K. J. H. Robson, and A. Crisanti. 1993. Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes. EMBO J. 12:2881-2889.
22. Pacheco, N. D., C. P. A. Strome, F. Mitchell, M. P. Bawden, and R. L. Beaudoin. 1979. Rapid large-scale isolation of Plasmodium berghei sporozoites from infected mosquitoes. J. Parasitol. 65:414-417.
23. Pancake, S. J., G. D. Holt, S. Mellouk, and S. L. Huffman. 1992. Malaria sporozoites and circumsporozoite proteins bind specifically to sulfated glycoconjugates. J. Cell Biol. 117:1351-1357.
24. Reichlin, M. 1980. Use of glutaraldehyde as a coupling agent for proteins and peptides. Methods Enzymol. 70:159-165.
25. Robson, K. J. H., U. Frevert, I. Reckmann, G. Cowan, J. Beier, I. G. Scragg, K. Takehara, D. H. L. Bishop, G. Pradel, R. Sinden, S. Saccheo, H. M. Muller, and A. Crisanti. 1995. Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum: expression during sporozoite ontogeny and binding to human hepatocytes. EMBO J. 14:3883-3894.
26. Robson, K. J. H., J. R. S. Hall, L. C. Davies, A. Crisanti, A. V. Hill, and T. E. Wellems. 1990. Polymorphism of the TRAP gene of Plasmodium falciparum. Proc. R. Soc. Lond. B 242:205-216.
27. Robson, K. J. H., J. R. S. Hall, M. W. Jennings, T. J. R. Harris, K. Marsh, C. I. Newbold, V. E. Tate, and D. J. Weatherall. 1988. A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature 335:79-82.
28. Rogers, W. O., A. Malik, S. Mellouk, K. Nakamura, M. D. Rogers, A. Szarfman, D. M. Gordon, A. K. Nussler, M. Aikawa, and S. L. Hoffman. 1992. Characterization of Plasmodium falciparum sporozoite surface protein 2. Proc. Natl. Acad. Sci. USA 89:9176-9180.
29. Rogers, W. O., M. D. Rogers, R. C. Hedstrom, and S. L. Hoffman. 1992. Characterization of the gene encoding sporozoite surface protein 2, a protective Plasmodium yoelii sporozoite antigen. Mol. Biochem. Parasitol. 53: 45-52.
30. Scarselli, E., R. Tolle, O. Koita, M. Diallo, H. M. Muller, K. Fruh, O. Doumbo, A. Crisanti, and H. Bujard. 1993. Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum. Infect. Immun. 61:3490-3495.
31. Sharma, P., A. Bharadwaj, V. K. Bhasin, V. N. Sailaja, and V. S. Chauhan. 1996. Antibodies to a conserved-motif peptide sequence of the Plasmodium falciparum thrombospondin-related anonymous protein and circumsporozoite protein recognize a 78-kilodalton protein in the asexual blood stages of the parasite and inhibit merozoite invasion in vitro. Infect. Immun. 64:2172-2179.
32. Sinnis, P., P. Clavijo, D. Fenyo, B. T. Chait, C. Cerami, and V. Nussenzweig. 1994. Structural and functional properties of region II-plus of the malaria circurnsporozoite protein. J. Exp. Med. 180:297-306.
33. Templeton, T. J., and D. C. Kaslow. 1997. Cloning and cross-species comparison of the thrombospondin-related anonymous protein (TRAP) gene from Plasmodium knowlesi, Plasmodium vivax and Plasmodium gallinaceum. Mol. Biochem. Parasitol. 84:13-24.
34. Valmori, D., A. Pessi, E. Bianchi, and G. Corradin. 1992. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J. Immunol. 149:717-721.
35. Valmori, D., J. F. Romero, Y. Men, J. L. Maryanski, P. Romero, and G. Corradin. 1994. Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): further enhancement by pre-injection of IFA alone. Eur. J. Immunol. 24:1458-1462.
36. Wang, R., Y. Charoenvit, G. Corradin, P. De la Vega, E. D. Franke, and S. L. Hoffman. 1996. Protection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell- and IFN-γdependent elimination of infected hepatocytes. J. Immunol. 157:4061-4067.
37. Wang, R., Y. Charoenvit, G. Corradin, R. Porrozzi, R. L. Hunter, G. Glenn, C. R. Alving, P. Church, and S. L. Huffman. 1995. Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. J. Immunol. 154:2784- 2793.
38. Wizel, B., R. Houghten, P. Church, J. A. Tine, D. E. Lanar, D. M. Gordon, W. R. Ballou, A. Sette, and S. L. Hoffman. 1995. HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers. J. Immunol. 155:766-775.
39. Wizel, B., R. A. Houghten, K. C. Parker, J. E. Coligan, P. Church, D. M. Gordon, W. R. Ballou, and S. L. Hoffman. 1995. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2. J. Exp. Med. 182:1435-1445.
40. Wizel, B., W. O. Rogers, R. A. Houghten, D. E. Lanar, J. A. Tine, and S. L. Hoffman. 1994. Induction of murine cytotoxic T lymphocytes against Plasmodium falciparum sporozoite surface protein 2. Eur. J. Immunol. 24:1487-1495.