Clinical trials in lung cancer: Nihilism versus enthusiasm

Thorax

Volumn 52, Issue 7, 1997, Pages 598-604

  Spiro, Stephen G ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; ETOPOSIDE; MELPHALAN; SODIUM;

AGE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; META ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; SURVIVAL RATE; TUMOR VOLUME;

EID: 0030760736     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.7.598     Document Type: Conference Paper

References (20)

1. Souhami RL, Geddes DM, Spiro SG, Harper PG, Tobias JS, Mantell BS, et al. Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. BMJ 1984;284:1643-6.
2. Pignon J-P, Arriagada R, Ihde DC, Johnson DH, Perry MC, Souhami RL, et al. A meta-analysis of thoracic radiotherapy for small cell lung cancer. N Engl J Med 1992;327:1618-24.
3. Murray N, Coy P, Pater JL, Hodson I, Arnold A, Zee BC, et al. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small cell lung cancer. J Clin Oncol 1993;11:336-44.
4. Souhami RL, Bradbury I, Geddes DM, Spiro SG, Harper PG, Tobias JS. Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res 1985;45:2878-82.
5. Spiro SG, Souhami RL, Geddes DM, Ash CM, Quinn H, Harper PG, et al. Duration of chemotherapy in small cell lung cancer. Br J Cancer 1980;59:578-83.
6. Medical Research Council Lung Cancer Working Party. Controlled trial of twelve versus six courses of chemotherapy in the treatment of small cell lung cancer. Br J Cancer 1989;59:584-90.
7. Cullen MH, Morgan D, Gregory W, Robinson M, Cox D, McGivern D, et al. Maintenance chemotherapy for anaplastic small cell carcinoma of the bronchus: a randomised controlled trial. Cancer Chemother Pharmacol 1986;17:157-60.
8. Medical Research Council Lung Cancer Working Party. A randomised trial of three or six courses of etoposide, cyclophosphamide, methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC). I: survival and prognostic factors. Br J Cancer 1993;68:1150-6.
9. Earl HM, Rudd RM, Spiro SG, Ash CM, James LE, Law CS, et al. A randomised trial of planned versus as required chemotherapy in small cell lung cancer: a Cancer Research Campaign trial. Br J Cancer 1991;64:566-72.
10. Gower NH, Rudd RM, Ruiz de Elvira M-C, Spiro SG, James LE, Harper PG, et al. Assessment of 'quality of life' using a daily diary card in a randomised trial of chemotherapy in small cell lung cancer. Ann Oncol 1995; 6:575-80.
11. Souhami RL, Rudd R, Ruiz de Elvira M-C, James L, Gower N, Harper PG, et al. Randomised trial comparing weekly versus 3-weekly chemotherapy in small cell lung cancer: a Cancer Research Campaign trial. J Clin Oncol 1994;12: 1806-13.
12. Souhami RL, Finn G, Gregory WM, Birkhead BG, Buckman R, Edwards D, et al. High-dose cyclophosphamide in small cell carcinoma of the lung. J Clin Oncol 1985;3: 958-63.
13. Medical Research Council Lung Cancer Working Party. Comparison of oral etoposide and standard intravenous multi-drug chemotherapy for small cell lung cancer: a stopped multi-centre randomised trial. Lancet 1996;348: 563-6.
14. Souhami RL, Spiro SG, Rudd RM, Ruiz de Elvira M-C, James LE, Gower NH, et al. Five day oral etoposide treatment for advanced small cell lung cancer: a randomised comparison with intravenous chemotherapy. J Natl Cancer Inst 1997;89:577-80.
15. Brown JS, Eraut D, Trask C, Davison AG. Age and the treatment of lung cancer. Thorax 1996;51:564-8.
16. Sepherd FA, Amdemichael E, Evans WK, Chalvardjian P, Hogg-Johnson S, Coates R, et al. Treatment of small cell lung cancer in the elderly. J Am Geriatr Soc 1994;42: 64-70.
17. Fentiman IS, Tirelli U, Monfardini S, Schneider M, Festen J, Cognetti F, et al. Cancer in the elderly: why so badly treated? Lancet 1990;335:1020-2.
18. Muers MF, Haward RA. Management of lung cancer. Thorax 1996; 51: 557-60.
19. Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non small cell lung cancer: a meta-analysis using updated data in individual patients from 52 randomised clinical trials. BMJ 1995; 311: 899-909.
20. Department of Health, Welsh Office. A policy framework for commissioning cancer services. A report of the expert advisory group on cancer to the Chief Medical Officer of England and Wales. London: Department of Health, 1995.