Inhibition of hela cell proliferation by 4-hydroxynonenal is associated with enhanced expression of the c-fos oncogene

Cancer Biotherapy and Radiopharmaceuticals

Volumn 12, Issue 2, 1997, Pages 131-136

  Kreuzer, Thomas ^a   Žarković, Neven ^b   Grube, Regina ^a   Schaur, Rudolf Jörg ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

4 hydroxynonenal; c fos; Carcinoma; Cell proliferation; Growth control; HeLa; Oncogenes; Oxidative stress; Serum

Indexed keywords

4 HYDROXYNONENAL; ALDEHYDE; MESSENGER RNA;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL;

EID: 0030760411     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.1997.12.131     Document Type: Article

References (35)

1. Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 1997;22:269-285
2. Chai YC, Howe PH, Dicorleto PE, Chisolm GM. Oxidized low density lipoproteins and lysophosphatidylcholine stimulate cell cycle entry in vascular smooth muscle cells - evidence for release of fibroblast growth factor-2. J Biol Chem 1996;271:17791-17797.
3. Schauenstein E, Esterbauer H, Zollner H. Aldehydes in biological systems; their natural occurence and biological activities. Pion Ltd, London, 1977.
4. Massotti L, Casali E, Galeotti T. Lipid peroxidation in tumor cells. Free Radical Biol Med 1988;4:377-386.
5. Floyd RA. Role of oxygen free radicals in cancerogenesis and brain ischemia. FASEB J 1990;4:2587-2597.
6. Esterbauer H, Zollner H, Schaur RJ. Aldehydes formed by lipid peroxidation: me-chanisms of formation, occurence, and determination In: Membrane Lipid Oxidation, Vol. I(Vigo-Pelfrey C., ed) CRC Press, Inc: Boca Raton, Florida, 1990, pp239-268.
7. Toyokuni S, Uchida K, Hattori-Nakakuki Y, et al. Formation of 4-hydroxy-2-none-nal-modified proteins in renal proximal tubules of rats treated with renal carcinogen, ferric nitrilotriacetate Proc Natl Acad Sci USA 1994;91:2616-2620.
8. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal. malonaldehyde and related aldehydes. Free Radical Biol Med 1991;11:81-128.
9. Schaur RJ, Zollner H, Esterbauer H. Biological effects of aldehydes with particular attention to 4-hydroxynonenal and malonaldehyde. In: Membrane lipid oxidation, Vol. III (Vigo-Pelfrey C., ed) CRC Press, Inc: Boca Raton, Florida, 1991, pp 141-163.
10. 2 N, Schlag G, Redl H, Waeg G. Brain damage secondary to hemorrhagic shock in baboons In: Shock, Sepsis and Organ Failure, 5th Wiggers Bernard Conference (Schlag G, Redl H, Traber DL, eds.), Springer-Verlag, Heidelberg, 1997, pp. 146-160.
11. Strohmaier H, Hinghofer-Szalkay H, Schaur RJ. Detection of 4-hydroxynonenal (HNE) as a physiological component in human plasma. J Lipid Mediators Cell Signalling 1995;11:51-61.
12. Allevi P, Anastasia M, Cajone F, Ciuffreda P, Sanvito AM. Structural requirements of aldehydes produced in LPO for the activation of the heat shock genes in HeLa cells. Free Radic Biol Med 1995;18:107-116.
13. Dianzani MU, Poli RA, Canuto MA, et al. New data on kinetics of lipid peroxidation in experimental hepatomas and preneoplastic nodules. Toxicol Pathol 1986;14:404-410.
14. Tillian HM, Hammer A, Kink E, et al. Iron-induced lipid peroxidation and inhibition of proliferation of Ehrlich ascites tumor cells. J Cancer Res Clin Oncol 1989;115:79-83.
15. Fazio VM, Rinaldi M, Ciafre S, et al. Control of neoplastic cell proliferation and differentiation by restoration of 4-hydroxynonenal physiological concentrations. Molec Aspects Med 1993;14:217-228.
16. 2 N, Iliæ Z, Jurin M, Schaur RJ, Puhl H, Esterbauer H. Stimulation of HeLa cell growth by physiological concentrations of 4-hydroxynonenal. Cell Biochemistry and Function 1993;11: 279-286
17. 2N, Schaur RJ, Puhl H, et al. Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro. Free Radical Biol Med 1994;16:877-884
18. 2 N, Tillian MH, Schaur RJ, Waeg G, Jurin M, Esterbauer H. Inhibition of melanoma B16-F10 growth by lipid peroxidation product 4-hydoxynonenal. Cancer Biotherapy 1995;10:153-156.
19. Cahill MA, Janknecht R, Nordheim A Signal uptake by the c-fos serum response element In Inducible gene expression, Vol. II ( Baeuerle PA, Ed ), Birkhauser, Boston-Basel-Berlin, 1995, pp 39-72.
20. Camandola S, Scavazza A, Leonarduzzi G, Biasi F, Chiarpotto E, Azzi A, Poli G. Biogemc 4-hydoxy-2-nonenal activates transcription factors AP-1 but not NF-KB in cells of the macrophage lineage. BioFactors 1997; in press
21. Esterbauer H, Weger W. Über die wirkungen von aldehyden auf gesunde und maligne zellen; synthese von homologen 4-hydroxy-2-alkenalen. Chem Monthly 1967;98:1884-1891.
22. Crawford D, Zbinden I, Amstad P, Cerutti P Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cell. Oncogene 1988;3:27-33.
23. 2 N, Schaur RJ. Impaired proliferation and DNA synthesis of a human tumour cell line (HeLa) caused by a short treatment with anti-anaemic drug Jectofer (ferric-sorbitol-citrate) and the lipid peroxidation product 4-hydroxynonenal. J Exp Therap and Oncology 1997: in press
24. Colotta F, Polentarutti N, Sironi M, Mantovani A. Expression and involvement of c-fos and c-jun proto-oncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 1992;267:18278-18283.
25. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson LM, Curran T, Morgan JI. Continuos c-fos expression precedes programmed cell death in vivo. Nature 1993;363:166-169.
26. Fazio VM, Barrera G, Martinotti S, Farace MG, Giglioni B, Frati L, Manzari V, Dianzani MU. 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells. Cancer Res 1992;52:4866-4871.
27. Barrera G, Pizzimenti S, Muraca R, Barbiero G, Bonelli G, Baccino FM, Fazio VM, Dianzani MU Effect of 4-hydoxynonenal on cell cycle progression and expression of differentiation-associated antigens in HL-60. Free Radic Biol Med 1996;20:455-462
28. Pan ZH, Perzepolo R. Role of nerve growth factor in oxidant homeostasis-glutathione metabolism J Neurochemistry 1993;61:1713-1721.
29. Göktürk E, Turgut A, Baycu C, Günal I, Seber S, Gülbas Z. Oxygen-free radicals impair fracture healing in rats. Acta Orthop Scand 1995;66:473-475.
30. Barcelloshoff MH, Dix TA Redox-mediated activation of latent transforming growth factors-beta-1. Molecular Endocrinol 1996;10:1077-1083.
31. Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF. NGF, BDNF and NT-5, but not NT-3 protect against MPP(+) toxicity and oxidative stress in neonatal animals. Brain Res 1996;713:178-185.
32. Ding GH, Vangoor H, Ricardo SD, Orlowski N, Diamond JR. Oxidized LDL stimulates the expression of TGF-beta and fibronectin in human glomerulal epithelial cells. Kidney Inter 1997;51:147-154.
33. Chen Q, Esterbauer H, Jürgens G. Studies on epitopes on low-density lipoprotein modified by 4-hy-droxynonenal. Biochem J 1992;288:249-254.
34. Waeg G, Dimsity G, Esterbauer H. Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. Free Rad Res 1996;15:149-158.
35. 2 N, Waeg G. Histological aspects of sepsis-induced brain changes in a baboon model. In: Shock, Sepsis and Organ Failure, 5th Wiggers Bernard Conference (Schlag G, Redl H, Traber DL, eds.), Springer-Verlag, Heidelberg, 1997:pp 3-17.