'Vitamin CE,' a novel prodrug form of vitamin E

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 6, 1997, Pages 1080-1084

  Rosenau, Thomas ^a   Habicher, Wolf Dieter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

5a substituted tocopherol; 5a tocopheryl ascorbate; Ascorbic acid; Prodrug; Vitamin E; tocopherol

Indexed keywords

5ALPHA TOCOPHEROL ASCORBATE; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ASCORBIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ALPHA TOCOPHEROL DEFICIENCY; ARTICLE; DRUG BINDING; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE CELL; MALABSORPTION; VITAMIN INTAKE;

EID: 0030760172     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1080     Document Type: Article

References (26)

1. Rosenau T., Habicher W. D., Tetrahedron, 51, 7919-7926 (1995).
2. Rosenau T., Chen C. L., Habicher W. D., J. Org. Chem., 60, 8120-8121 (1995).
3. Rosenau T., Habicher W. D., Heterocycles, 43, 787-798 (1996); idem, Synlen, 5, 427-429 (1996).
4. Rosenau T., Habicher W. D., Heterocycles, 43, 787-798 (1996); idem, Synlen, 5, 427-429 (1996).
5. Rosenau T., Habicher W. D., Book of Abstracts, 212th ACS National Meeting, Orlando, August 1996, Part 2, ORGN 322.
6. Nelan D. R., Robeson C. D., J. Am. Chem. Soc., 84, 2963-2965 (1962); Schudel P., Mayer H., Metzger J., Rüegg R., Isler O., Helv. Chim. Acta, 46, 636-649 (1963).
7. Nelan D. R., Robeson C. D., J. Am. Chem. Soc., 84, 2963-2965 (1962); Schudel P., Mayer H., Metzger J., Rüegg R., Isler O., Helv. Chim. Acta, 46, 636-649 (1963).
8. Schudel P., Mayer H., Metzger J., Rüegg R., Isler O., Helv. Chim. Acta, 46, 333-343 (1963); John W., Z. Phisiol. Chem., 252, 222-224 (1938).
9. Schudel P., Mayer H., Metzger J., Rüegg R., Isler O., Helv. Chim. Acta, 46, 333-343 (1963); John W., Z. Phisiol. Chem., 252, 222-224 (1938).
10. Gallo-Torres H. E., "Vitamin E: A Comprehensive Treatise," ed. by Machlin L. J., Marcel Dekker, New York, 1980, pp. 170-192.
11. Rosenblum J. L., Keating J. P., Prensky A. L., Nelson J. S., N. Engl. J. Med., 304, 503-508 (1981).
12. Traber M. G., Goldberg I., Davidson E., Lagmay N., Kayden H. J., Gastroenterology, 98, 96-103 (1990).
13. Pearson C., Legge A., Biochim. Biophys. Acta, 288, 404-412 (1972).
14. Vitamin E deficiency was observed in patients with abetalipoproteinemia, cystic fibrosis, cholestasis syndrome, or congenital hemolytic anemia, and treated in early stages with water-soluble vitamin E preparations on a trial basis: Sokol R. J., Heubi J. E., Butler-Simon N., McClung H. J., Lilly J. R., Silverman A., Gastroenterology, 93, 975-985 (1987); Traber M. G., Thellman C. A., Rindler M. J., Kayden H. J., Am. J. Clin. Nutr., 48, 605-611 (1988); Bieri J. G., Corash L., Hubbard V. S., N. Engl. J. Med., 308, 1063-1072 (1983).
15. Vitamin E deficiency was observed in patients with abetalipoproteinemia, cystic fibrosis, cholestasis syndrome, or congenital hemolytic anemia, and treated in early stages with water-soluble vitamin E preparations on a trial basis: Sokol R. J., Heubi J. E., Butler-Simon N., McClung H. J., Lilly J. R., Silverman A., Gastroenterology, 93, 975-985 (1987); Traber M. G., Thellman C. A., Rindler M. J., Kayden H. J., Am. J. Clin. Nutr., 48, 605-611 (1988); Bieri J. G., Corash L., Hubbard V. S., N. Engl. J. Med., 308, 1063-1072 (1983).
16. Vitamin E deficiency was observed in patients with abetalipoproteinemia, cystic fibrosis, cholestasis syndrome, or congenital hemolytic anemia, and treated in early stages with water-soluble vitamin E preparations on a trial basis: Sokol R. J., Heubi J. E., Butler-Simon N., McClung H. J., Lilly J. R., Silverman A., Gastroenterology, 93, 975-985 (1987); Traber M. G., Thellman C. A., Rindler M. J., Kayden H. J., Am. J. Clin. Nutr., 48, 605-611 (1988); Bieri J. G., Corash L., Hubbard V. S., N. Engl. J. Med., 308, 1063-1072 (1983).
17. Guggenheim M., Ringel S., Silverman A., Grabert B., J. Pediat., 100, 51-58 (1982); Sokol R. J., Heubi J. E., Iannaconne S., Bove K. E., Harris R. E., Balistreri W. F., Gastroenterology, 85, 1172-1182 (1983); Jeffrey G., Muller D., Burroughs A., J. Hepatol., 4, 307-317 (1987).
18. Guggenheim M., Ringel S., Silverman A., Grabert B., J. Pediat., 100, 51-58 (1982); Sokol R. J., Heubi J. E., Iannaconne S., Bove K. E., Harris R. E., Balistreri W. F., Gastroenterology, 85, 1172-1182 (1983); Jeffrey G., Muller D., Burroughs A., J. Hepatol., 4, 307-317 (1987).
19. Guggenheim M., Ringel S., Silverman A., Grabert B., J. Pediat., 100, 51-58 (1982); Sokol R. J., Heubi J. E., Iannaconne S., Bove K. E., Harris R. E., Balistreri W. F., Gastroenterology, 85, 1172-1182 (1983); Jeffrey G., Muller D., Burroughs A., J. Hepatol., 4, 307-317 (1987).
20. Bennett M., Medwadowski B., Am. J. Clin. Nutr., 20, 415-421 (1967); Harries J., Muller D., Arch. Dis. Child., 46, 341-344 (1971); Farrell P., Bieri J., Fratantoni J., Wood R., Di Sant'Agnese P., J. Clin. Invest., 60, 233-241 (1977); Stead R. J., Muller D. P. R., Matthews S., Hodson M. E., Batten J. C., Gut., 27, 714-718 (1986).
21. Bennett M., Medwadowski B., Am. J. Clin. Nutr., 20, 415-421 (1967); Harries J., Muller D., Arch. Dis. Child., 46, 341-344 (1971); Farrell P., Bieri J., Fratantoni J., Wood R., Di Sant'Agnese P., J. Clin. Invest., 60, 233-241 (1977); Stead R. J., Muller D. P. R., Matthews S., Hodson M. E., Batten J. C., Gut., 27, 714-718 (1986).
22. Bennett M., Medwadowski B., Am. J. Clin. Nutr., 20, 415-421 (1967); Harries J., Muller D., Arch. Dis. Child., 46, 341-344 (1971); Farrell P., Bieri J., Fratantoni J., Wood R., Di Sant'Agnese P., J. Clin. Invest., 60, 233-241 (1977); Stead R. J., Muller D. P. R., Matthews S., Hodson M. E., Batten J. C., Gut., 27, 714-718 (1986).
23. Bennett M., Medwadowski B., Am. J. Clin. Nutr., 20, 415-421 (1967); Harries J., Muller D., Arch. Dis. Child., 46, 341-344 (1971); Farrell P., Bieri J., Fratantoni J., Wood R., Di Sant'Agnese P., J. Clin. Invest., 60, 233-241 (1977); Stead R. J., Muller D. P. R., Matthews S., Hodson M. E., Batten J. C., Gut., 27, 714-718 (1986).
24. IUPAC-IUB, Eur. J. Biochem., 123, 473-480 (1982).
25. Baczyk S., Swidzinska K., Mikrochim. Acta., 2, 259-264 (1975); Dabrowski K., Hinterleitner S., Analyst, 11, 83-87 (1989).
26. Baczyk S., Swidzinska K., Mikrochim. Acta., 2, 259-264 (1975); Dabrowski K., Hinterleitner S., Analyst, 11, 83-87 (1989).