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1
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0031016235
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Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis
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Cheng P, Schmutte C, Cofer KF, Felix JC, Yu MC, Dubeau L: Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis. Br J Cancer 1993, 75:396-402. This study examines differences in global DNA methylation between ovarian cystadenomas, LMP tumors, and carcinomas. The results support the idea that cystadenomas are fundamentally different from the more aggressive tumors at the molecular genetic level.
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Br J Cancer
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Cheng, P.1
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Cofer, K.F.3
Felix, J.C.4
Yu, M.C.5
Dubeau, L.6
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2
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0343618377
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Histologic transformation of benign endometriosis to early epithelial ovarian cancer
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Sainz de la Cuesta R, Eichhorn JH, Rice LW, Fuller AF Jr, Nikrui N, Goff BA: Histologic transformation of benign endometriosis to early epithelial ovarian cancer. Gynecol Oncol 1996, 60:238-244.
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Fuller Jr., A.F.4
Nikrui, N.5
Goff, B.A.6
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3
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0031002034
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Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts
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Jimbo H, Hitomi Y, Yoshikawa H, Yano T, Momoeda M, Sakamoto A, Tsutsumi O, Taketani Y, Esumi H: Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. Am J Pathol 1997, 150:1173-1178.
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Am J Pathol
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Sakamoto, A.6
Tsutsumi, O.7
Taketani, Y.8
Esumi, H.9
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4
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0027476142
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Molecular genetic evidence of a unifocal origin for human serous ovarian carcinoma
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Tsao S-W, Mok C-H, Knapp RC, Oike K, Muto MG, Welch WR, Goodman HM, Sheets EE, Berkowitz RS, Lau CC: Molecular genetic evidence of a unifocal origin for human serous ovarian carcinoma. Gynecol Oncol 1993, 48:5-10.
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Gynecol Oncol
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Tsao, S.-W.1
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Knapp, R.C.3
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Muto, M.G.5
Welch, W.R.6
Goodman, H.M.7
Sheets, E.E.8
Berkowitz, R.S.9
Lau, C.C.10
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5
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0027485172
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Advanced ovarian carcinoma: Molecular evidence of unifocal origin
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Li S, Resnik E, Carcangiu ML, Schwartz PE, Yang-Feng TL: Advanced ovarian carcinoma: molecular evidence of unifocal origin. Gynecol Oncol 1993, 51:21-25.
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Gynecol Oncol
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Li, S.1
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Schwartz, P.E.4
Yang-Feng, T.L.5
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6
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0029874863
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Evidence for unifocal origin in familial ovarian cancer
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Gallion HH, Guarino DA, DePriest PD, van Nagell JR Jr, Vaccarello L, Berek JS, Pieretti M: Evidence for unifocal origin in familial ovarian cancer. Am J Obstet Gynecol 1996, 174:1102-1108.
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Am J Obstet Gynecol
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Gallion, H.H.1
Guarino, D.A.2
DePriest, P.D.3
Van Nagell Jr., J.R.4
Vaccarello, L.5
Berek, J.S.6
Pieretti, M.7
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7
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0030046778
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Concordance of DNA ploidy pattern as measured by flow cytometry in primary, metastatic, and persistent ovarian cancer
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Zanetta GM, Keeney GL, Kimlinger TK, Katzmann JA, Podratz KC: Concordance of DNA ploidy pattern as measured by flow cytometry in primary, metastatic, and persistent ovarian cancer. Gynecol Oncol 1996, 60:213-216. Molecular genetic evidence for a unifocal origin of ovarian epithelial cancer.
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Gynecol Oncol
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Zanetta, G.M.1
Keeney, G.L.2
Kimlinger, T.K.3
Katzmann, J.A.4
Podratz, K.C.5
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8
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0029871876
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Primary peritoneal serous papillary carcinoma: A study of 25 cases and comparison with stage III-IV ovarian serous carcinoma
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Ben-Baruch G, Sivan E, Moran O, Rizel S, Menczer J, Seidman DS: Primary peritoneal serous papillary carcinoma: a study of 25 cases and comparison with stage III-IV ovarian serous carcinoma. Gynecol Oncol 1996, 60:393-396.
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Ben-Baruch, G.1
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Menczer, J.5
Seidman, D.S.6
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9
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0030036738
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Origins of heterogeneous ovarian carcinoma: A molecular cytogenetic analysis of histologically benign, low malignant potential, and fully malignant components
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Wolf NG, Abdul-Karim FW, Schork NJ, Schwartz S: Origins of heterogeneous ovarian carcinoma: a molecular cytogenetic analysis of histologically benign, low malignant potential, and fully malignant components. Am J Pathol 1996, 149:511-520.
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Am J Pathol
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Wolf, N.G.1
Abdul-Karim, F.W.2
Schork, N.J.3
Schwartz, S.4
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10
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0027859004
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Histologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas
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Zheng J, Wan M, Zweizig S, Yu MC, Dubeau L: Histologically benign or low-grade malignant tumors adjacent to high-grade ovarian carcinomas contain molecular characteristics of high-grade carcinomas. Cancer Res 1993, 53:4138-4142.
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Zheng, J.1
Wan, M.2
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Yu, M.C.4
Dubeau, L.5
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0029123053
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Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas
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Zheng J, Benedict WF, Xu H-J, Hu S-X, Kim TM, Velicescu M, Wan M, Cofer KF, Dubeau L: Genetic disparity between morphologically benign cysts contiguous to ovarian carcinomas and solitary cystadenomas. J Natl Cancer Inst 1995, 87:1146-1153. By examining concordance of genetic abnormalities in ovarian carcinomas and contiguous benign-looking cysts, Wolf et al. [9••], Zheng et al. [10•], and Zheng et al. [11••] address the issue of whether or not the benign-looking components are precursors of the malignant components.
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J Natl Cancer Inst
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Zheng, J.1
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Velicescu, M.6
Wan, M.7
Cofer, K.F.8
Dubeau, L.9
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0031014476
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Analysis of loss of heterozygosity and Kras2 mutations in ovarian neoplasms: Clinicopathological correlations
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Chenevix-Trench G, Kerr J, Hurst T, Shih Y-C, Purdie D, Bergman L, Friedlander M, Sanderson B, Zournazi A, Coombs T, et al.: Analysis of loss of heterozygosity and Kras2 mutations in ovarian neoplasms: clinicopathological correlations. Genes Chromosome Cancer 1997, 18:75-83. This paper compares allelotypes of ovarian cystadenomas, LMP tumors, and carcinomas, and examines ras mutations in the same tumors. The results provide further evidence that these three tumor subtypes are mechanistically different.
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Genes Chromosome Cancer
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Chenevix-Trench, G.1
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Friedlander, M.7
Sanderson, B.8
Zournazi, A.9
Coombs, T.10
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Mutations of K-ras proto-oncogene in human ovarian epithelial tumors of borderline malignancy
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Mok SC-H, Bell DA, Knapp RC, Fishbaugh PM, Welch WR, Muto MG, Berkowitz RS, Tsao S-W: Mutations of K-ras proto-oncogene in human ovarian epithelial tumors of borderline malignancy. Cancer Res 1993, 53:1489-1492
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Mok, S.C.-H.1
Bell, D.A.2
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Muto, M.G.6
Berkowitz, R.S.7
Tsao, S.-W.8
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0027182705
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p53 and Ki-ras gene mutations in epithelial ovarian neoplasms
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Teneriello MG, Ebina M, Linnoila RI, Henry M, Nash JD, Park RC, Birrer MJ: p53 and Ki-ras gene mutations in epithelial ovarian neoplasms. Cancer Res 1993, 53:3103-3108.
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Teneriello, M.G.1
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Henry, M.4
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Park, R.C.6
Birrer, M.J.7
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15844408830
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Potential role of the inactivated X chromosome in ovarian epithelial tumor development
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Cheng PC, Gosewehr JA, Kim TM, Velicescu M, Wan M, Zheng J, Felix JC, Cofer KF, Luo P, Biela BH, et al.: Potential role of the inactivated X chromosome in ovarian epithelial tumor development. J Natl Cancer Inst 1996, 88:510-518. This study compares the frequencies of losses of heterozygosity in ovarian cystadenomas, LMP tumors, and carcinomas, and formulates a genetic model of ovarian tumor development based on the findings.
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J Natl Cancer Inst
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Cheng, P.C.1
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Felix, J.C.7
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Luo, P.9
Biela, B.H.10
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Subclassification of serous borderline tumors of the ovary into benign and malignant types: A clinicopathologic study of 65 advanced stage cases
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Seidman JD, Kurman RJ: Subclassification of serous borderline tumors of the ovary into benign and malignant types: a clinicopathologic study of 65 advanced stage cases. Am J Surg Pathol 1996, 20:1331-1345. This paper formulates provocative thoughts on the subclassification and biologic behavior of LMP tumors based on the results of a clinicopathologic study of advanced cases.
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Am J Surg Pathol
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Seidman, J.D.1
Kurman, R.J.2
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Identification of two candidate tumor suppressor genes on chromosome 17p13.3
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Schultz DC, Vanderveer L, Berman DB, Hamilton TC, Wong AJ, Godwin AK: Identification of two candidate tumor suppressor genes on chromosome 17p13.3. Cancer Res 1996, 56:1997-2002.
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Godwin, A.K.6
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Identification of zinc finger mRNAs using domain-specific differential display
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Johnson SW, Lissy NA, Miller PD, Testa JR, Ozols RF, Hamilton TC: Identification of zinc finger mRNAs using domain-specific differential display. Anal Biochem 1996, 236:348-352.
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Nm23 expression in advanced and borderline ovarian carcinoma
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Schneider J, Romero H, Ruiz R, Centeno MM, Rodriguez-Escudero FJ: Nm23 expression in advanced and borderline ovarian carcinoma. Anticancer Res 1996, 16:1197-1202.
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Elevated nm23 protein expression is correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma
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Srivatsa PJ, Cliby WA, Keeney GL, Dodson MK, Suman VJ, Roche PC, Podratz KC: Elevated nm23 protein expression is correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma. Gynecol Oncol 1996, 60:363-372. This study provides evidence that nm23 protein expression is a prognostic determinant for ovarian cancer.
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Gynecol Oncol
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Srivatsa, P.J.1
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Podratz, K.C.7
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SPARC, an extracellular matrix protein with tumor-suppressing activity in ovarian epithelial cells
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Mok SC, Chan WY, Wong KK, Muto MG, Berkowitz RS: SPARC, an extracellular matrix protein with tumor-suppressing activity in ovarian epithelial cells. Oncogene 1996, 12:1895-1901.
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Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q
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A novel 4-cM minimally deleted region on chromosome 11p15.1 associated with high grade nonmucinous epithelial ovarian carcinomas
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Lu KH, Weitzel JN, Kodali S, Welch WR, Berkowitz RS, Mok SC: A novel 4-cM minimally deleted region on chromosome 11p15.1 associated with high grade nonmucinous epithelial ovarian carcinomas. Cancer Res 1997, 57:387-390.
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Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer
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Davis M, Hitchcock A, Foulkes WD, Campbell IG: Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer. Cancer Res 1996, 56:741-744.
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Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2
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Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression
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