The prevalence of Fragile-X syndrome in an institution for people with learning disability

Psychiatric Genetics

Volumn 7, Issue 3, 1997, Pages 115-119

  O'Dwyer, J ^a   Holmes, J ^b   Mueller, R ^c   Taylor, G ^c  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

^b SEACROFT HOSPITAL   (United Kingdom)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Fragile X syndrome; Prevalence; Screening

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL GENETICS; CONTROLLED STUDY; DNA DETERMINATION; FAMILY HISTORY; FRAGILE X SYNDROME; HUMAN; HUMAN CELL; INSTITUTIONAL CARE; LEARNING DISORDER; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; PREVALENCE; PRIORITY JOURNAL;

EID: 0030759118     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199723000-00005     Document Type: Article

References (44)

1. Allan WH, Herndon CN and Dudley FC (1944) Some examples of mental deficiency: apparently sex-linked idiocy and microcephaly. American Journal of Mental Deficiencies, 48, 325-334.
2. Arinami T, Kundo I and Nakajima S, (1986) Frequency of the Fragile-X syndrome in Japanese mentally retarded males. Human Genetics, 73, 309-312.
3. Blomquist HK, Gustavson KH, Holmgren G, Nordenson I and Sweins A (1982) Fragile-X chromosomes and X-linked mental retardation in severely retarded boys in a Northern Swedish county. A prevalence study. Clinical Genetics, 21, 209-214.
4. Blomquist HK, Gustavson KH, Holmgren G, Nordenson I and Palsson-Strae U (1983) Fragile-X syndrome in mildly mentally retarded children in a Northern Swedish county. A prevalence study. Clinical Genetics, 24, 393-398.
5. Blomquist HK, Bohman M, Edvinsson S, Gillberg C, Gustavson K, Holmgren G and Wahlstrom J (1985) Frequency of the Fragile-X syndrome in infantile autism. A Swedish multicentre study. Clinical Genetics, 27, 113-117.
6. Bundey S, Webb T, Thake A and Todd J (1985) A community study of severe mental retardation in the West Midlands and the importance of the Fragile-X chromosome in its aetiology. Journal of Medical Genetics, 22, 258-266.
7. Butler MG and Singh DN, (1993) Clinical and cytogenetic survey of institutionalised mentally retarded patients, with emphasis on the Fragile-X syndrome. Journal of Intellectual Disability Research, 37, 131-142.
8. Butler MG, Pratesi R, Watson MS, Breg W and Singh D (1993) Anthropometric and craniofacial patterns in mentally retarded males with emphasis on the Fragile-X syndrome. Clinical Genetics, 44, 129-138.
9. Carpenter NJ, Leichtman LG and Say B (1982) Fragile-X linked mental retardation. A survey of 65 patients with mental retardation of unknown origin. American Journal of Diseases of Children, 136, 392-398.
10. Chudley A and Hagerman R (1987) Fragile-X syndrome. Medical Progress Journal of Pediatrics, 110, 821-831.
11. English C (1986) PhD thesis. Cytogenetic, anthropometric and inheritance studies in the Fragile-X syndrome. University of Newcastle-Upon-Tyne, UK.
12. Froster-Iskenius U, Felsch G, Schirren C and Schwinger E (1983) Screening for Fra(X)(q) in a population of mentally retarded males. Human Genetics, 63, 153-157.
13. Fryns JP (1989) In: The Fragile-X Syndrome (Ed K Davies) pp 1-39. Oxford University Press, Oxford, UK.
14. Fryns JP, Volche P, Haspeslagh M, Beunsen L and Van den Berghe H (1990) A genetic diagnostic survey in an institutionalised population of 262 moderately mentally retarded patients. Journal of Mental Deficiency Research 34, 29-40.
15. Gabarron J, Lopez I, Glover G and Carbonell P (1992) Fragile-X screening programme in a Spanish Region. American Journal of Medical Genetics, 43, 333-338.
16. Gostason R, Wahlstrom J, Johannisson T and Holmquist D (1991) Chromosomal abnormalities in mild mental retardation. Journal Mental Deficiency Research, 35, 240-246.
17. Gustavson HK, Blomquist HK and Holmgren G (1986) Prevalence of Fragile-X syndrome in mentally retarded children in a Swedish county. American Journal of Medical Genetics, 23, 591-597.
18. Herbst DS, Dunn HG, Dill FJ, Kalousek DK and Krywaniuk LW (1981) Further delineation of X-linked mental retardation. Human Genetics, 58, 366-372.
19. Hofstee Y, Arinami T and Hamaguchi H (1994) Comparison between the cytogenetic test for fragile-X and the molecular analysis of the FMR-1 gene in Japanese mentally retarded individuals. American Journal of Medical Genetics, 51, 466-470.
20. Jacobs PA, Glover T, Mayer M, Fox P, Gerrard J, Dunn H and Herbst D (1980) X-linked mental retardation: a study of 7 families. American Journal of Medical Genetics, 7, 471-489.
21. Johnson GE (1897) Contribution to the psychology and pedagogy of feeble-minded children. Journal of Psycho-Astenics, 2, 26-32.
22. Kahkonen M, Leisti J, Wilska M and Varonen S (1983) Marker X-associated mental retardation. A study of 150 retarded males. Clinical Genetics, 23, 397-404.
23. Kahkonen M, Alitalo T, Airaksinen E, Matilainen R, Launiala K, Autio S and Leisti J (1987) Prevalence of the Fragile-X syndrome in four birth cohorts of children of school age. Human Genetics, 77, 85-87.
24. Knight SJL, Ritchie RJ, Chakrabarti L, Cross G, Taylor GR, Mueller RF, Hurst J, Paterson J, Yates JRW, Dow DJ and Davies KE (1996) A Study of FRAXE in mentally retarded individuals referred for Fragile-X (FRAXA) syndrome testing in the United Kingdom. American Journal of Human Genetics, 58, 906-913.
25. Loehr JP, Synhorst DP, Wolfe RR and Hagerman RJ (1986) Aortic root dilatation and mitral valve prolapse in the Fragile-X syndrome. American Journal of Medical Genetics, 23, 189-194.
26. Lubs HA (1969). A marker X-chromosome. American Journal of Human Genetics, 21, 231-244.
27. Martin JP and Bell J (1943) A pedigree of mental defect showing sex-linkage. Journal of Neurological Psychiatry, 6, 154-157.
28. Mattei JF, Mattei MG, Aumeras C, Auger M and Giraud F (1981). X-linked mental retardation with the Fragile-X. A study of 15 families. Human Genetics, 59, 281-289.
29. Mazurezak T, Bocain E, Milewski M, Obersztyn E, Stanezak H, Bal J, Szamotulska K and Karwacki MW (1996) Frequency of the Fragile-X syndrome among institutionalized mentally retarded males in Poland. American Journal of Medical Genetics, 64, 184-186.
30. Nanba E, Kohno Y, Matsuda A, Yano M, Sato C, Hashimoto K, Koeda T, Yoshino K, Kimura M, Maeoka Y et al. (1995) Non-radioactive DNA diagnosis for the fragile-X syndrome in mentally retarded Japanese males. Brain Development, 17, 317-321.
31. Neri G, Sanfilippo S, Pavone L, Mollica F, Barberi I, Giuffre L, Romano C, Mattina T, Cammarata M and Ragusa M (1988) The Fragile-X in Sicily: an epidemiological survey. American Journal of Medical Genetics, 30, 665-672.
32. Nolin S, Snider D, Jenkins E, Dobkin C, Patchell K, Krawczum, Strong G, Colwell M, Victor A and Payyapilli T (1992) New York state screening program for the Fragile-X syndrome, a progress report. American Journal of Medical Genetics, 43, 328-332.
33. Paika IJ, Lai F, McAllister NM and Miller WA (1984) The Fragile-X marker survey: preliminary report of screening of suspected Fragile-X syndrome patients at Ferhald State School. American Journal of Human Genetics, 36, 108S.
34. Piven J, Gayle J, Landa R, Wzorek M and Folstein S (1991) The prevalence of fragile X in a sample of autistic individuals using a standardized interview. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 825-830.
35. Primrose DA, El Matmati R, Boyd E, Gosden C and Newton M (1986) Prevalence of the Fragile-X syndrome in an institution for the mentally handicapped. British Journal of Psychiatry, 148, 655-657.
36. Sutherland GR (1982) Heritable fragile sites on human chromosomes VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. American Journal of Human Genetics, 34, 452-458.
37. Tranebjaerg L and Kure P (1991) Prevalence of fra(X) and other specific diagnoses in autistic individuals in a Danish county. American Journal of Medical Genetics, 38, 212-214.
38. Tranebjaerg L, Hilling S, Jessen J, Lind D and Hansen MS (1994) Prevalence of fra (X) in the county of Funen in Denmark is lower than expected. American Journal of Medical Genetics, 51, 423-427.
39. Turner G, Robinson H, Laing S, van den Berk M, Colley A, Goddard A, Sherman S and Partington M (1992) Population Screening for Fragile-X. Lancet 339, 1210-1213.
40. Verkerk A, Paieretti M, Sutcliffe J, Fu Y-H, Khul D, Pizzuti R, Reiner O, Richards S, Victoria M and Zhang F (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in Fragile-X syndrome. Cell 65, 905-914.
41. Waldstein G and Hagerman R (1988) Aortic hypoplasia and cardiac valvular abnornalities in a boy with Fragile-X syndrome. American Journal of Medical Genetics, 30, 83-98.
42. Webb T, Bundey S, Thake J and Todd A (1986) The frequency of the Fragile-X chromosome among schoolchildren in Coventry. Journal of Medical Genetics, 23, 396-399.
43. Wong VC and Lam ST, (1992) Fragile-X positivity in Chinese children with autistic spectrum disorder. Pediatric Neurology, 8, 272-274.
44. Yanghong G, Ying S, Gibbs RA and Nelson DL (1996) Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nature Genetics, 13, 109-113.