Cytosolic NADPH-UQ reductase-linked recycling of cellular ubiquinol: Its protective effect against carbon tetrachloride hepatotoxicity in rat

Molecular Aspects of Medicine

Volumn 18, Issue SUPPL., 1997, Pages 71-77

  Kishi, T ^a   Takahashi, T ^a   Okamoto, T ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Antioxidant; Carbon tetrachloride; Lipid peroxidation; Rat liver; Ubiquinol

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CARBON TETRACHLORIDE; GLUTATHIONE; LIVER ENZYME; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATITIS; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALIA;

EID: 0030759031     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0098-2997(97)00030-7     Document Type: Conference Paper

References (14)

1. Bertelli, A., Giovannini, L., Bertelli, A. A., Maltinti, G., Scalori, V. and Romano, M. R. (1986). Tissue concentrations of coenzyme Q in liver of rats intoxicated by carbon tetrachloride. International Journal of Tissue Reactions, 8, 343-346.
2. Beyer, R. E. (1988). Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems. Free Radicals in Biology and Medicine, 5, 297-303.
3. Ernster, L. and Dallner, G. (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochimica Biophysica Acta, 1271, 195-204.
4. Ernster, L. and Forsmark-Andrée, P. (1993). Ubiquinol: an endogenous antioxidant in aerobic organisms. The Clinical Investigator, 71, S60-S65.
5. Frei, B., Kim, M. C. and Ames, B. N. (1990). Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences of the USA, 87, 4879-4883.
6. Kalén, A., Appelkvist, E.-L., Chojnacki, T. and Dallner, G. (1990). Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver. Journal of Biological Chemistry, 265, 1158-1164.
7. Mukai, K., Morimoto, H., Kikuchi, S. and Nagaoka, S. (1993). Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solution. Biochimica Biophysica Acta, 1157, 313-317.
8. Rechnagel, R. O. and Glende, E. A. Jr. (1973). Carbon tetrachloride hepatotoxicity: an example of lethal cleavage. CRC Critical Reviews in Toxicology, 2, 263-297.
9. Takahashi, T., Shitashige, M., Okamoto, T., Kishi, T. and Goshima, K. (1992). A novel ubiquinone reductase activity in rat liver cytosol. FEBS Letters, 314, 331-334.
10. Takahashi, T., Okamoto, T., Mori, K., Sayo, H. and Kishi, T. (1993). Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids, 28, 803-809.
11. Takahashi, T., Yamaguchi, T., Shitashige, M., Okamoto, T. and Kishi, T. (1995). Reduction of ubiquinone in membrane lipids by rat liver cytosol and its involvement in the cellular defence system against lipid peroxidation. Biochemical Journal, 309, 883-890.
12. Takahashi, T., Okamoto, T. and Kishi, T. (1996a). Characterization of NADPH-depentent ubiquinone reductase activity in rat liver cytosol: effect of various factors on ubiquinone-reacting activity and discrimination from other quinone reductases. Journal of Biochemistry (Tokyo), 119, 256-263.
13. Takahashi, T., Sugimoto, N., Takahata, K., Okamoto, T. and Kshi, T. (1996b). Cellular antioxidant defense by a ubiquinol-regenerating system coupled with cytosolic NADPH-dependent ubiquinone reductase: protective effect against carbon tetrachloride-induced hepatotoxicity in the rat. Biological and Pharmaceutical Bulletin, 19, 1005-1012.
14. Yamamoto, Y., Komuro, E. and Niki, E. (1990). Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome. Journal of Nutritional Science and Vitaminology, 36, 505-511.