Quantitative Evaluation of the Rate of Myocardial Interstitial Fibrosis Using a Personal Computer

Japanese Circulation Journal

Volumn 61, Issue 9, 1997, Pages 781-786

  Kitamura, Masaru ^a   Shimizu, Masami ^a   Kita, Yoshihito ^a   Yoshio, Hiroyuki ^a   Ino, Hidekazu ^a   Misawa, Katsushi ^a   Matsuyama, Tom ^a   Mabuchi, Hiroshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Computer analysis; Hydroxyproline; Myocardial interstitial fibrosis; Point counting method

Indexed keywords

COLLAGEN; HYDROXYPROLINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; FEMALE; HAMSTER; HEART MUSCLE BIOPSY; HEART MUSCLE FIBROSIS; HUMAN; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; IMAGE ANALYSIS; MALE; MICROCOMPUTER; NONHUMAN; OBSERVER VARIATION; RELIABILITY; REPRODUCIBILITY;

ADULT; ANIMALS; CARDIOMYOPATHY, HYPERTROPHIC; CRICETINAE; ENDOMYOCARDIAL FIBROSIS; EVALUATION STUDIES; FEMALE; HUMANS; HYDROXYPROLINE; IMAGE PROCESSING, COMPUTER-ASSISTED; LINEAR MODELS; MALE; MICROCOMPUTERS; MIDDLE AGED; OBSERVER VARIATION; REPRODUCIBILITY OF RESULTS;

EID: 0030758849     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.61.781     Document Type: Article

References (18)

1. Weber K. T.: Cardiac interstitium in health and disease: The fibrillar collagen network. J Am Coll Cardiol 1989; 13: 1637-1652.
2. Weber K. T., Janicki I. S., Shroff S. G., Pick R., Chen R. M., Bashey R. I.: Collagen remodeling of the pressure-overloaded hypertrophied nonhuman primate myocardium. Circ Res 1988; 62: 757-765.
3. Iimoto D. S., Covell J. W., Harper E: Increase in cross-linking of type I and type III collagens associated with volume-overloaded hypertrophy. Circ Res 1988; 21: 399-408.
4. Shimizu M., Umeda K., Sugihara N., Yoshio H., Ino H., Takeda R., et al: Collagen remodeling in myocardia of patients with diabetes. J Clin Pathol 1993; 46, 32-36.
5. Tanamura A., Takeda N., Iwai T., Tuchiya M., Arino T., Nagano M.: Myocardial contractility and ventricular myosin isoenzymes as influenced by cardiac hypertrophy and its regression. Basic Res Cardiol 1993; 74: 72-79.
6. Kawai S., Shimizu M., Okada R., Ih S.: A morphological analysis of chronic myocarditis. Jpn Circ J 1987; 51: 1385-1392.
7. Sugihara N., Genda A., Shimizu M., Suematu T., Kita Y., Horita Y., et al: Quantification of myocardial fibrosis and its relation to function in essential hypertension and hypertrophic cardiomyopathy. Clin Cardiol 1988; 11: 771-778.
8. Unverferth D. V., Baker P. B., Pearce L. I., Lautman J., RobertW. C.: Resional myocyte hypertrophy and increased interstitial myocardial fibrosis in hypertrophic cardiomyopathy. Am J Cardiol 1987; 59: 932-936.
9. Kawai S., Okada R.: Interstitial cell infiltrate and myocardial fibrosis in dilated cardiomyopathy: A special type of cardiomegaly corresponding to sequelae myocarditis. Heart Vessels 1990; 5: 230-236.
10. Van Suylen R. J., Van Bekkum E.E.C., Boersma H., De Kok L. B., Balk A.H.M.M., Bos E., et al: Collagen content and distribution in the normal and transplanted human heart: A postmortem quantitative light microscopic analysis. Cardiovasc Pathol 1996; 5: 61-68.
11. Baandrup U., Olson E. G. J.: Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. I. Morphological and morphometric aspects. Br Heart J 1981; 45: 475-486.
12. Baandrup U., Florio R. A., Rehahn M., Richrdson P. J., Olsan E. G.: Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. II. Comparison of histology and clinical/haemodynamic information. Br Heart J 1981; 45: 487-493.
13. Hoyt R., Erickson E., Collins S. M., Skorton D. J.: Computer-assisted quantification of myocardial fibrosis in histologic sections. Arch Pathol Lab Med 1984; 108: 280-283.
14. Pickering J. G., Bougner D. R.: Fibrosis in the transplanted heart and its relation to donor ischemic time. Assessment with polarized light microscopy and digital image analysis. Circulation 1990; 81: 949-958.
15. Araki T., Shimizu M., Sugihara N., Yoshio H., Ino H., Takeda R.: Effect of angiotensin-converting enzyme inhibitor on myocardial collagen metabolism in cardiomyopathic hamsters. In: Nagano M., Takeda N., Naranjan S., editors. The cardiomyopathic heart, 1994; 15: 137-143.
16. Inayama S., Shibata T., Ohtsuki I. T., Saito S.: A new microanalytical method for determination of hydroxyproline in connective tissues. Keio J Med 1978; 27: 43-46.
17. Stinson E. B., Billingham M. E.: Correlative study of regional left ventricular histology. Am J Cardiol 1977; 39: 378-383.
18. Anderson K. R., Sutton M. G., Lie J. T.: Histopathological types of cardiac fibrosis in myocardial disease. J Pathol 1979; 128: 79-85.