A comparison of the standard approach and the NONMEM approach in the estimation of bioavailability in man

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 7, 1997, Pages 731-733

  Combrink, M ^a   Mcfadyen, M L ^a   Miller, R ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN;

ANALYTICAL ERROR; ARTICLE; CALCULATION; CLINICAL TRIAL; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DATA ANALYSIS; DRUG BIOAVAILABILITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; TECHNIQUE;

EID: 0030758659     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06101.x     Document Type: Article

References (10)

1. Beal, S. L. (1995) Intermediate Workshop in Population Pharmacokinetic Data Analysis using the NONMEM System. Sweden, October 12-13, 1995
2. Boeckmann, A. J., Sheiner, L. B., Beal, S. L. (1991) NONMEM Users Guide-Part V-Introductory Guide. University of California
3. Bolton, S. (1990) Transformations and outliers. In: Swarbrick, J. (ed.) Pharmaceutical Statistics: Practical and Clinical Applications. 2nd edn, Drugs and the Pharmaceutical Sciences, Vol. 44, Marcel Dekker, New York, pp 356-359
4. Graves, D. A., Chang, I. (1990) Pharmacometrics. Application of NONMEM to routine bioavailability data. J. Pharmacokin. Biopharm. 18: 145-160
5. Kaniwa, N., Aoyagi, N., Ogata, H., Ishii, M. (1990) Application of the NONMEM method to evaluation of the bioavailability of drug products. J. Pharm. Sci. 79: 1116-1120
6. Sheiner, L. B., Beal S. L. (1987) A note on confidence intervals with extended least squares parameter estimates. J. Pharmacokin. Biopharm. 15: 93-99
7. Sheiner, L. B., Beal, S. L. (1980) Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model: routine clinical pharmacokinetic data. J. Pharmacokin. Biopharm. 8: 553-570
8. Sheiner, L. B., Rosenberg, B., Marathe, V. V., Peck, C. (1974) Differences in serum digoxin concentrations between outpatients and inpatients: an effect on compliance. Clin. Pharmacol. Ther. 15: 239-246
9. Vozeh, S., Maitre, P. O., Stanski, D. R. (1990) Pharmacokinetics. Evaluation of population (NONMEM) pharmacokinetic parameter estimates. J. Pharmacokin. Biopharm. 18: 161-173
10. White, D. B., Walawander, C. A., Ying Tung, Grasela, T. H. (1991) Pharmacometrics. An evaluation of point and interval estimates in population pharmacokinetics using NONMEM analysis. J. Pharmacokin. Biopharm. 19: 87-112