B cell development in mice

International Reviews of Immunology

Volumn 15, Issue 3-4, 1997, Pages 207-241

  Kearney, John F ^a   Won, Woong Jai ^a   Benedict, Cindy ^a   Moratz, Chantal ^a   Zimmer, Paul ^a   Oliver, Alyce ^a   Martin, Flavius ^a   Shu, Fengyu ^a  

^a The University of Alabama at Birmingham   (United States)

Author keywords

Antibody diversity; B cells; Fetal liver; Immunoglobulin gene; Ontogeny; Splanchnopleura; Terminal deoxynucleotidyl transferase

Indexed keywords

EID: 0030758567     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189709068177     Document Type: Review

References (168)

1. Allman, D. M., Ferguson, S. E., and Cancro, M. P. (1992) "Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigen and exhibit unique signaling characteristics", J. Immunol., 149, 2533.
2. Allman, D. M., Ferguson, S. E., Lentz, V. M., and Cancro, M. P. (1993) "Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immune developmental intermediate in the production of long-lived marrow-derived B cells", J. Immunol., 151, 4431.
3. + and conventional B lymphocytes", Eur. J. Immunol., 19, 1117.
4. Bandyopadhyay, R. S., Teutsch, M. R., and Wortis, H. H. (1995) "Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA", Curr. Topics Micro. Immunol., 194, 219.
5. Bangs, L. A., Sanz, I. E., and Teale, J. M. (1991) "Comparison of D, Jh and junctional diversity in the fetal, adult, and aged B cell repertoires", J. Immunology, 146, 1996.
6. Bertrand, F. E. III, Billips, L. G., and Schroeder, H. W. Jr. (1995) "Analysis of DHQ52 gene segment transcription and rearrangement during B cell development in human fetal bone marrow", Ann. N. Y. Acad. Sci., 764, 228.
7. Bogue, M., Gilfillan, S., Benoist, C., and Mathis, D. (1992) "Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny", Proc. Natl. Acad. Sci. USA, 89, 11011.
8. Bona, C. A. (1992) "Expression of V gene families during ontogeny and establishment of B cell repertoire", Intern. Rev. Immunol., 8, 83.
9. Brinster, R. L., Ritchie, K. A., Hammer, R. E., O'Brien, R. L., Arp, B., and Storb, U. (1983) "Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice", Nature, 306, 332.
10. Caligaris-Cappio, F. and Janossy, G. (1985) "Surface markers in chronic lymphoid leukemias of B cell type", Sem. Hematol., 22, 1.
11. Cardell, S., Merkenschlager, M., Bodmer, H., Chan, S., Cosgrove, D., Benoist, C., and Mathis, D. (1994) "The immune system of mice lacking conventional MHC class II molecules", Adv. Immunol., 55, 423.
12. Carlsson, L. and Holmberg, D. (1990) "Genetic basis of the neonatal antibody repertoire:, germline V-gene expression and limited N-region diversity", Inter. Immunol., 2, 639.
13. Carmack, C. E., Shinton, S. A., Hayakawa, K., and Hardy, R. R. (1990) "Rearrangement and Selection of Vh11 in the Ly-1 B Cell lineage", J. Exp. Med., 172, 371.
14. + B lymphocytes as cells making antibodies binding multiple self and exogenous molecules", Intern. Rev. Immunol., 3, 17.
15. Chen, C., Nagy, Z., Luning Prak, E., and Weigert, M. (1995) "Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing", Immunity, 3, 747.
16. Cohen, D. P. and Rothstein, T. L. (1991) "Elevated levels of protein kinase C activity and alpha-isoenzyme expression in murine peritoneal B cells", J. Immunol., 146, 2921.
17. Cook, J. L., Ikle, D. N., and Routes, B. A. (1995) "Natural killer cell ontogeny in the athymic rat", J. Immunol., 155, 5512-5518.
18. Cumano, A., Dieterlen-Lievre, F., and Godin, I. (1996) "Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura", Cell, 86, 907.
19. Dauphinee, M., Tovar, Z., and Talal, N. (1988) "B cells expressing CD5 are increased in Sjögren's syndrome", Arthr. Rheum., 31, 642.
20. + lineage of B lympocyte differentiation", J. Immunol., 133, 744.
21. + B cells in immunodeficient CBA/N mice", J. Exp. Med., 166, 804.
22. Deenen, G. J. and Kroese, F. G. (1993) "Kinetics of B cell subpopulations in peripheral lymphoid tissues: evidence for the presence of phenotypically distinct short-lived and long-lived B cell subsets", Inter. Immunol. 5, 735.
23. Delassus, S. and Cumano, A. (1996) "Circulation of hematopoietic progenitors in the mouse embryo", Immunity, 4, 97.
24. Deryugina, E. I. and Müller-Sieburg, C. E. (1993) "Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development?", Critical Rev. Immunol., 13, 115.
25. Ehlich, A., Martin, V., Muller, W., and Rajewsky, K. (1994) "Analysis of the B-cell progenitor compartment at the level of single cells", Curr. Biol., 4, 573-583,
26. Feeney, A. J. (1992) "Comparison of junctional diversity in the neonatal and adult immunoglobulin repertoires", Intern. Rev. Immunol., 8, 113.
27. Forster, I., Gu, H., and Rajewsky, K. (1988) "Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment", EMBO J. 7, 3693.
28. Foy, T. M., Lynch, R. G., and Waldschmidt, T. J. (1992) "Ontogeny and distribution of the murine B cell Fc gamma RII", J. Immunol., 149, 1516.
29. French, L. E., Hahne, M., Viard, I., Radlgruber, G., Zanone, R., Becker, K., Muller, C., and Tschopp, J. (1996) "Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover", J. Cell Biol., 133, 335.
30. Gavin, M. A. and Bevan, M. J. (1995) "Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire", Immunity, 3, 793.
31. Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993) "Receptor editing: an approach by autoreactive B cells to escape tolerance", J. Exp. Med., 177, 999.
32. Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C., and Mathis, D. (1993) "Mice lacking TdT: Mature animals with an immature lymphocyte repertoire", Science, 261, 1175.
33. Gilfillan, S., Waltzinger, C., Benoist, C., and Mathis, D. (1994) "More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase", Inter. Immunol., 6, 1681.
34. Godin, E. I., Dieterlen-Lievre, F., and Cumano, A. (1995b) "Emergence of multipotent hemopoietic cells in the yolk sac and para-aortic splanchnopleura in mouse embryos, beginning at 8.5 days post-coitus", Proc. Natl. Acad. Sci. USA, 92, 773.
35. Godin, I. E., Dieterlen-Lievre, F., and Cumano, A. (1995a) "B-lymphoid potential in pre-liver mouse embryo", Sem. Immunol., 7, 131.
36. Godin, I., Garcia-Porrero, J., Coutinho, A., Dieterlen-Lievre, F., and Marcos, M. (1993) "Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors", Nature, 364, 67.
37. Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., and Raphael, K. (1988) "Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice", Nature, 334, 676.
38. Gosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C., and Mathis, D. (1991) "Mice lacking MHC class II molecules", Cell, 66, 1051.
39. - B lymphocyte subsets", Eur. J. Immunol., 12, 564.
40. Gregoire, K. E., Goldschneider, I., Barton, R. W., and Bollum, F. J. (1979) "Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphopoietic tissues of rat and mouse", J. Immunology, 123, 1347.
41. Greiner, D. L., Goldschneider, I., Komschlies, K. L., Medlock, E. S., Bollum, F. J., and Schultz, L. (1986) "Defective lymphopoiesis in bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice", J. Exp. Med., 164, 1129.
42. Grosschedl, R., Weaver, D., Baltimore, D., and Constantini, F. (1984) "Introduction of a mu immunoglobulin gene into the mouse germline: specific expression in lymphoid cells and synthesis of functional antibody", Cell, 38, 647.
43. Grossi, C. E., Velardi, A., and Cooper, M. D. (1985) "Postnatal liver hemopoiesis in mice: generation of pre-B cells, granulocytes, and erythrocytes in discrete colonies", J. Immunol., 135, 2303.
44. Grupp, S., Harmony, J., Baluyut, A., and Subbarao, B. (1987) "Early events in B-cell activation: anti-Lyb2, but not BSF-12, induces a phosphatidylinositol response in murien B cells", Cell. Immunol., 110, 131.
45. H joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation", EMBO J., 9, 2133.
46. Hamilton, A. M., Lehuen, A., and Kearney, J. F. (1994) "Immunofluorescence analysis of B-1 cell ontogeny in the mouse", Inter. Immunol., 6, 355.
47. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., and Hayakawa, K. (1991) "Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow", J. Exp. Med., 173, 1213.
48. H gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells", J. Immunol., 142, 3643.
49. Hardy, R. R., Hayakawa, K., Parks, D. R., and Herzenberg, L. A. (1983) "Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-color immunoftuorescence", Nature, 306, 270.
50. Hasegawa, K., Abe, M., Okada, T., Hirose, S., Sato, H., and Shirai, T. (1989) "Are Ly1 B cells responsible for the IL-2-hyperresponsiveness of B cells in autoimmuneprone NZBxNZW F1 mice?", Inter. Immunol., 1, 99.
51. + B cells", Curr. Opin. Immunol., 2, 582.
52. Hayakawa, K., Tarlinton, D., and Hardy, R. R. (1994) "Absence of MHC II expression distinguishes fetal from adult b lymphopoiesis in mice", J. Immunol., 152, 4801.
53. Hayakawa, K., Hardy, R. R., Park, D. R., and Herzenberg, L. A. (1983) "The "Ly-1B" cell subpopulation in normal, immunodefective, and autoimmune mice", J. Exp. Med., 157, 202.
54. Hayakawa, K., Hardy, R. R., Stall, A. M., Herzenberg, L. A., and Herzenberg, L. A., (1986) "Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage" Eur. J. Immunol., 16, 1313.
55. Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D., and Herzenberg, L. A. (1984) "Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies", Proc. Natl. Acad. Sci. USA, 81, 2494.
56. Herzenberg, L. A., Stall, A. M., Lalor, P. A., Sidman, C., Moore, W. A., Parks, D. R., and Herzenberg, L. A. (1986) "The Ly-1 B cell lineage", Immunol. Rev., 93, 81.
57. Herzenberg, Leonore, A., Stall, A. M., Braun, J., Weaver, D., Baltimore, D., Herzenbert, Leonard, A., and Grosschedl, R. (1987) "Depletion of the predominant B cell population in immunoglobulin mu heavy chain transgenic mice", Nature, 329, 71.
58. + B cells", J. Immunol., 144, 4218.
59. Holmberg, D. (1986) "High connectivity, natural antibodies preferentially use 7183 and QUPC 52 VH families", Eur. J. Med., 17, 399.
60. Huang, H. S., Jones, N. H., Strominger, J. L., and Herzenberg, L. A. (1987) "Molecular cloning of Ly-1, a membrane glycoprotein of mouse T lymphocytes and a subset of B cells: Molecular homology to its human counterpart Leu-1/T1 (CD5)", Proc. Natl. Acad. Sci. USA, 84, 204.
61. Huang, H. and Auerbach, R. (1993) "Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo", Proc. Natl. Acad. Sci. USA, 90, 10110.
62. Ikuta, K., Uchida, N., Friedman, J., and Weissman, I. L. (1992) "Lymphocyte development from stem cells. [Review]", Annu. Rev. Immunol., 10, 759.
63. Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y. H., and Weissman, I. L. (1990) "A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells", Cell, 62, 863.
64. H gene family expression". J. Exp. Med., 168, 589.
65. Jones, N. H., Clabby, M. L., Dialynas, D. P., Huang, H. S., Herzenberg, L. A., and Strominger, J. L. (1986) "Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1", Nature, 323, 346.
66. Jurgens, J. B., Gartland, L. A., Du Pasquier, L., Horton, J. D., Gobel, T. W., and Cooper, M. D. (1995) "Identification of a candidate CD5 homologue in the amphibian Xenopus laevis", J. Immunol., 155, 4218.
67. Kantor, A. (1991) "The development and repertoire of B-1 cells (CD5 B cells)", Immunol. Today, 12, 389.
68. Kantor, A. B., Stall, A. M., Adams, A., Herzenberg, L. A., and Herzenberg, L. A. (1992) "Adoptive transfer of murine B-cell lineages", Ann. N. Y. Acad. Sci., 651, 168.
69. Kantor, A. B., Stall, A. M., Adams, A., Herzenberg, L. A., and Herzenberg, L. A. (1992) "Differential development of progentior activity for three B-cell lineages", Proc. Natl. Acad. Sci. USA, 89, 3320.
70. Kearney, J. F., Bartels, J., Hamilton, A. M., Lehuen, A., Solvason, N., and Vakil, M. (1992) "Development and Function of the Early B Cell Repertoire", Inter. Rev. Immunol., 8, 247.
71. Kearney, J. F., Cooper, M. D., Klein, J., Abney, E. R., Parkhouse, R. M., and Lawton, A. R. (1977) "Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice", J. Exp. Med., 146, 297.
72. Keyna, U., Beck-Engeser, G. B., Jongstra, J., Applequist, S. E., and Jack, H.-M. (1995) "Surrogate light chain-dependent selection of Ig heavy chain V regions", J. Immunol., 155, 5536.
73. Kincade, P. W., Lee, G., Watanabe, T., Sun, L., and Scheid, M. P. (1981) "Antigens displayed on murine B lymphocyte precursors", J. Immunol., 152, 4801
74. Kitamura, D., Kudo, A., Schaal, S., Muller, W., Melchers, F., and Rajewsky, K. (1992) "A critical role of lambda 5 protein in B cell development", Cell, 69, 823.
75. Kolber, D. L., Shulk, L. D., and Rothstein, T. L. (1991) "Phorbol ester responsiveness of murine Ly-1 lineage B cells from normal and viable motheaten mutant mice", Eur. J. Immunol., 21, 721.
76. Komori, T., Okada, A., Steward, V., and Alt, F. W. (1993) "Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes", Science, 261, 1171.
77. Kraal, G. and Janse, M. (1986a) "Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody". Immunology, 58, 665.
78. Kraal, G., Breel, M., Janse, M., and Bruin, G. (1986b) "Langerhans" cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody". J. Exp. Med., 163, 981.
79. Kroese, F. G. M., de Waard, R., and Bos, N.A. (1996) "B-1 cells and their reactivity with the murine intestinal microflora", Sem. Immunol., 8, 11.
80. Lam, K.-P. and Stall, A. M. (1994) "Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny", J. Exp. Med., 180, 507.
81. Lanier, L. L., Warner, N. L., Ledbetter, J. A., and Herzenberg, L. A. (1981) "Expression of Lyt-1 antigen on certain murine B cell lymphomas", J. Exp. Med., 153, 998.
82. Lankester, A. C., van Schijndel G. M. W., Cordell, J. L., van Noesel, C. J. M., and van Lier, R. A. W. (1994) "CD5 is associated with the human B cell antigen receptor complex", Eur. J. Immuol., 24, 812.
83. Ledbetter, J. A., Martin, P. J., Spooner, C. E., Wofsy, D., Tsu, T. T., Betty, P. G., and Gladstone, P. (1985) "Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells", J. Immunol., 135, 2331.
84. Lehuen, A., Monteiro, R. C., and Kearney, J. F. (1992) "Identification of a surface protein (p100) associated with two glycosyl-phosphatidylinositol-linked molecules (Thy-1 and ThB) by natural anti-lymphocyte auto antibodies", Eur. J. Immunol., 22, 2373.
85. Li, Y-S., Hayakawa, K., and Hardy, R. R. (1993) "The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver", J. Exp. Med., 178, 951.
86. Li, Y-S., Hayakawa, K., and Hardy, R. R. (1993) "The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver", J. Exp. Med., 173, 1213.
87. Liu, Y. J., Zhang, , Lane, P. J., Chan, E. Y., and MacLennan, I. C. (1991) "Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens [published erratum appears in Eur. J. Immunol. 1992 Feb. 22(2), 615]", Eur. J. Immunol., 21, 2951.
88. Luo, W., Van de Velde, H., Von Hoegen, I., Parnes, J. R., and Thielemans, K. (1992) "Ly-1 (CD5), a membrane glycoprotien of mouse T lymphocytes and subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72)", J. Immunol., 148, 1630.
89. Müller, A., Medvinsky, A., Strouboulis, J., Grosveld, F., and Dzierzak, E. (1994) "Development of hematopoietic stem cell activity in the mouse embryo", Immunity, 1, 291.
90. MacLennan, I. C. and Liu, Y. J. (1991a) "Marginal zone B cells respond both to polysaccharide antigens and protein antigens. [Review]", Res. Immunol., 142, 346.
91. MacLennan, I. C., Johnson, G. D., Liu, Y. J., and Gordon, J. (1991b) "The heterogeneity of follicular reactions. [Review]", Res. Immunol., 142, 253.
92. Manohar, V., Brown, E., Leiserson, W. M., and Chused, T. M. (1982) "Expression of Lyt-1 by a subset of B Lymphocytes", J. Immunol., 129, 532.
93. h81x transgene bearing B cells in fetus and adult: sites for expansion and deletion in conventional and CD5/B1 cells", Intern. Immunol. in press.
94. Martinez-Valdez, H., Guret, C., de Bouteiller, O., Fugier, I., Banchereau, J., and Liu, Y. J. (1996) "Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2", J. Exp. Med., 183, 971.
95. McAteer, M. J., Lagarde, A., Georgiou, H. M., and Bellgrau, D. (1988) "A requirement for the CD5 antigen in T cell activation", Eur. J. Immunol., 18, 1111.
96. Medvinsky, A., Samoylina, N., Müller, A., and Dzierzak, E. (1993) "An early pre-liver intraembryonic source of CFU-S in the developing mouse", Nature, 364, 64.
97. Medvinsky, A. and Dzierzak, E. (1996) "Definitive hematopoiesis is autonomously initiated by the AGM region", Cell, 86, 897.
98. Meek, K. (1990) "Analysis of junctional diversity during B lymphocyte development", Science, 250, 820.
99. Melchers, F., Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., Ghia, P., and Andersson, J. (1995) "Positive and negative selection events during B lymphopoiesis", Curr. Opin. Immunol., 1, 214.
100. Melchers, F., Haasner, D., Grawunder, U., Kalberer, C., Karasuyama, H., Winkler, T., and Rolink, A. G. (1994) "Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. [Review]", Annu. Rev. Immunol., 12, 209.
101. Miyazaki, T., Wolf, P., Tourne, S., Walzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C., and Mathis, D. (1996) "Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway", Cell, 84, 531.
102. Mond, J. J., Vos, Q., Lees, A., and Snapper, C. M. (1995) "T cell independent antigens. [Review]", Curr. Opin. Immunol., 7, 349.
103. Monroe, J. G. (1996) "Tolerance sensitivity of immature stage B cells", J. Immunol., 156, 2657.
104. Monroe, J. G. (1996) "Tolerance sensitivity of immature-stage B cells - can developmentally regulated B cell antigen receptor (BCR) signal transduction play a role?", J. Immunol., 156, 2657.
105. Morales-Alcelay, S., Gaspar, M. L., Godin, I., Dieterlen, L., Copin, S. G., and Marcos, M. A. R. (1995) "How B-cell developmental pathways are implicated in building mouse B-cell compartments", Methods: Compn. Meth. Enzymol., 8, 27.
106. Morris, D. and Rothstein, T. L. (1993) "Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes", J. Exp. Med., 177, 857.
107. Morris, D. and Rothstein, T. L. (1994) "Decreased surface IgM receptor-mediated activation of phospholipase Oγ2 in B-1 lymphocytes", Inter. Immunol., 6, 1011.
108. Murphy, T. P., Kobler, D. L., and Rothstein, T. L. (1990) "Elevated expression of Pgp-1 (Ly-24) by murine peritoneal B lymphocytes", Eur. J. Immunol., 20, 1137.
109. Nakajima, P. B., Datta, S. K., Schwartz, R. S., and Huber, B. T. (1979) "Localization of spontaneously hyperactive B cells of NZB mice to a specific B cell subset", Proc. Natl. Acad. Sci. USA, 76, 4613.
110. Nakayama, K., Negishi, I., Kuida, K., Shinkai, Y., Louie, M. C., Fields, L. E., Lucas, P. J., Stewart, V., Alt, F. W. et al. (1993) "Disappearance of the lymphoid system in bcI-2 homozygous mutant chimeric mice", Science, 261, 1584.
111. Nemazee, D. A. and Burki, K. (1989) "Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes", Nature, 337, 562.
112. Nishimura, Y., Bierer, B. E., Jones, W. K., Jones, N. H., Strominger, J. L., and Burakoff, S. J. (1988) "Expression and function of a CD5 cDNA in human and murine T cells", Eur. J. Immunol., 18, 747.
113. Ogawa, M., Nishikawa, S., Ikuta, K., Yamamura, F., Naito, M., Takahishi, K., and Nisbikawa, S. (1988) "B cell ontogeny in murine embryo studies by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than, in the yolk sac", EMBO J., 7, 1337.
114. Oliver, A., Martin, F., and Kearney, J. F. [Submitted].
115. Oliver, A., Martin, F., and Kearney, J. F. (1997) "Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells", J. Immunol., 158, 1108.
116. Owen, J. J. T., Cooper, M., and Raff, M. C. (1974) In vitro generation of B lymphocytes in mouse foetal liver, a mammalian "bursa equivalent" Nature, 249, 361.
117. + (CD5) B cells", Eur. J. Immunol., 19, 2115.
118. + B Cell Lymphomas", J. Immunol., 141, 2788.
119. Plater-Zyberk, C., Maini, R. N., Lam, K., Kennedy, T. D., and Janossy, G. (1985) "A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia", Arthr. Rheum., 28, 971.
120. Radic, M. Z., Erikson, J., Litwin, S., and Weigert, M. (1993) "B lymphocytes may escape tolerance by revising their antigen receptors", J. Exp. Med., 177, 1165.
121. + B cells predominant in peripheral tissues of rabbit", J. Immunol., 149, 3858,
122. Rodewald, H. R. (1995) "Pathways from hematopoietic stem cells to thymocytes", Curr. Opin Immunol., 7, 176.
123. Rodewald, H. R., Krekzschmar, K., Takeda, S., Hohl, C., and Dessing, M. (1994) "Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization", EMBO J., 13, 4229.
124. Rodewald, H. R., Kretzschmar, K., Swat, W., and Takeda, S. (1995) "Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo", Immunity, 3, 313.
125. Rolink, A., Grawunder, U., Winkler, T. H., Karasuyama, H., and Melchers, F. (1994) "IL-2 receptor α chain (CD25, TAC) expression defines a crucial stage in pre-B cell development", Inter. Immunol., 6, 1257.
126. Rolink, A., Ten Boekel, E., Melchers, F., Fearon, D. T., Krop, I., and Anderson, J. (1996) "A subpopulation of B220 positive cells in murine bone marrow does not express CD19 and contains NK progenitors", J. Exp. Med., 183, 187-194.
127. Rothstein, T. L. and Kolber, D. L. (1988b) "Anti-Ig antibody inhibits the phorbol ester-induced stimulation of peritoneal B cells", J. Immunol., 141, 4089.
128. Rothstein, T. L., and Kolber, D. L. (1988a) "Peritoneal B cells respond to phorbo! esters in the absence of co-mitogen", J. Immunol., 140, 2880.
129. Sherr, D. H., Dorf, M. E., Gibson, M., and Sidman, C. L. (1987) "Ly-1 B helper cells in autoimmune viable motheaten mice", J. Immunol., 139, 1811.
130. Shu, F., Holzmann, B., and Kearney, J. F. Identification of an activation epitope expressed by murine integrin α4 subunits. J. Biol. Chem. [Submitted].
131. + B cells in viable motheaten and normal mice", Science, 232, 1423.
132. Snapper, C. M., Yamada, H., Smoot, D., Sneed, R., Lees, A., and Mond, J. J. (1993) "Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells", J. Immunol., 150, 2737.
133. Snook, T. (1964) Anat. Rec., 148, 149.
134. Solvason, N., Lehuen, A., and Kearney, J. (1991) "An embryonic source of Ly1 but not conventional B cells", Inter. Immunol., 3, 543.
135. Stall, A. L., Farinas, M. C., Tarlinton, D. M., Lalor, P. A., Herzenberg, L. A., Strober, S., and Herzenberg, L. A. (1988) "Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals", Proc. Natl. Acad. Sci. USA, 85, 7312.
136. Stall, A. R., Adams, S., Herzenberg, L. A., and Kantor, A. B. (1992) "Characteristics and development of the murine B-1b (Ly-1 B sister) cell population", Ann. N. Y. Acad. Sci., 651, 33.
137. Storb, U., Pinkert, C., Arp, B., Engler, P., Gollahon, K., Manz, J., Brady, W., and Brinster, R. L. (1986) "Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies", J. Exp. Med., 164, 627.
138. Subbarao, B. and Mosier, D. (1983) "Induction of B lymphocyte proliferation by monoclonal anti-Lyb-2 antibody", J. Immunol., 130, 2033.
139. Subbarao, B. and Mosier, D. E. (1982) "Lyb antigens and their role in B lymphocyte activation", Immunol. Rev., 69, 81.
140. Talal, N. (1987) "Overview of Sjögren's syndrome", J. Den. Res., 66, 672.
141. Taniguchi, H., Toyoshima, T., Fukao, K., and Nakauchi, H. (1996) "Presence of hematopoietic stem cells in the adult liver", Nature Med., 2, 198.
142. Taniguchi, H., Toyoshima, T., Fukao, K., and Nakauchi, H. (1996) "Presence of hematopoietic stem cells in the adult liver [see comments]", Nature Med., 2, 198.
143. Tarakhovsky, A., Kanner, S. B., Hombach, J., Ledbetter, J. A., Muller, W., Killeen, N., and Rajewsky, K. (1995) "A role for CD5 in kTCR-mediated signal transduction and thymocyte selection", Science, 269, 535.
144. Tarakhovsky, A., Muller, W., and Rajewsky, K. (1994) "Lymphocyte populations and immune responses in CD5-deficient mice", Eur. J. Immunol., 24, 1678.
145. + Ly-1 B clones of (NZBxNZw)F1 mice", EMBO J., 7, 3705.
146. Teutsch, M., Higer, M., Wang, D., and Wortis, H. (1995) "Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin", Inter. Immunol., 7, 381.
147. Tiegs, S. L., Russell, D. M., and Nemazee, D. (1993) "Receptor editing in self-reactive bone marrow B cells", J. Exp, Med., 177, 1009.
148. Tseng, J. (1981) "Transfer of lymphocytes of Peyer's patches between immunoglobulin allotype congenic mice: repopulation of the IgA plasma cells in the gut lamina propria", J. Immunol., 127, 2039.
149. Tseng, J. (1984) "A population of resting IgM-IgD double-bearing lymphocytes in Peyer's patches: the major precursor cells for IgA plasma cells in the gut lamina propria", J. Immunol., 132, 2730.
150. Tsubata, T. and Nishikawa, S-I. (1991) "Molecular and cellular aspects of early B-cell development", Curr. Opin. Immunol., 3, 186.
151. Vakil, M. and Kearney, J. F. (1986) "Functional characterization of monoclonal autoanti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice", Eur. J. Immunol., 16, 1151.
152. Vakil, M. and Kearney, J. F. (1986) "Functional characterization of monoclonal auto-anti-idiotype antibodies isolated from the early B cell repertoire of BALB/c mice", Eur. J. Immunol., 16, 1151.
153. Vakil, M., Sauter, H., Paige, C., and Kearney, J. F. (1986) "In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire", Eur. J. Immunol., 16, 1159.
154. Van de Velde, H., von Hoegen, I., Luo, W., Parnes, J. R., and Thielmans, K. (1991) "The B-cell surface protein CD72/Lyb-2 is the ligand for CD5", Nature, 351, 662.
155. Veis, D. J., Sorenson, C. M., Shutter, J. R., and Korsmeyer, S. J. (1993) "Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair", Cell, 75, 229-240.
156. Velardi, A. and Cooper, M. D. (1984) "An immunofluorescence analysis of the ontogeny of myeloid, T, and B lineage cells in mouse hemopoietic tissues", J. Immunol., 133, 672.
157. bright B cells", Eur. J. Immunol., 24, 585.
158. Waldschmidt, T. J., Conrad, D. H., and Lynch, R. G. (1988) "The expression of B cell surface receptors. I. The ontogeny and distribution of the murine B cell IgE Fc receptor", J. Immunol., 140, 2148.
159. Wells, S. M., Kantor, A. B., and Stall, A. M. (1994) "CD43 (S7) expression identifies peripheral B cell subsets", J. Immunol., 5503.
160. Williams, A. F. and Gagnon, J. (1982) "Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin. [Review]", Science, 216, 696.
161. Wofsy, D. and Chiang, N. Y. (1987) "Proliferation of Ly-1 B cells in autoimmune NZB and (NZBxNZW)F1 mice", Eur. J. Immunol., 17, 809.
162. Wortis, H. H., Teutsch, M., Higer, M., Zheng, J., and Parker, D. C. (1995) "B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes", Proc. Natl. Acad. Sci. USA, 92, 3348.
163. Xu, B. and Seising, E. (1994) "Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene", Science, 265, 1590.
164. Yakura, H., Shen, F. W., Kaemmer, M., and Boyse, E. A. (1981) "Lyb-2 system of mouse B cells: evidence for a role in the generation of antibody forming cells", J. Exp. Med., 153, 129.
165. Ying-zi, C., Rabin, E., and Wortis, H. (1991) "Treatment of murine CDS B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways", Inter. Immunol., 3, 467.
166. Yoshida, T., Ikuta, K., Sugaya, H., Maki, K., Takagi, M., Kanazawa, H., Sunaga, S., Kinashi, T., Yoshimura, K., Miyazaki, J., Takaki, S., and Takatsu, K. (1996) "Defective B-1 cell development and impaired immunity against angiostrongylus cantonensis in IL-6R alpha-deficient mice", Immunity, 4, 483.
167. Zhang, Y., Cado, D., Asarnow, D. M., Komori, T., Alt, F. W., Raulet, D. H., and Allison, J. P. (1995) "The role of short homology repeats and Tdt in generation of the invariant gammadelta antigen receptor repertoire in the fetal thymus", Immunity, 3, 439.
168. - B cells: requirement for special stimuli", Eur. J. Immunol., 24, 1426.