Dissociation of effects of glutamate receptor antagonists on excitotoxic and hypoxic neuronal cell death in a novel rat cortical culture system

Brain Research Bulletin

Volumn 44, Issue 2, 1997, Pages 131-139

  Rogers, Derek C ^a   Hunter, A Jackie ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Calcium; Cortex; Excitotoxicity; Glutamate; Hypoxia; Neuronal culture

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DIZOCILPINE; FLUNARIZINE; GLUTAMATE RECEPTOR ANTAGONIST; LACTATE DEHYDROGENASE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NIFEDIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; SB 201823; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL CULTURE; CELL DEATH; CELL POPULATION; CELL PROTECTION; DISSOCIATION; EMBRYO; ENZYME INHIBITION; HYPOXIA; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANOXIA; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYTOLOGICAL TECHNIQUES; GLUTAMIC ACID; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; RATS; RECEPTORS, GLUTAMATE;

EID: 0030756763     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(97)00102-0     Document Type: Article

References (47)

1. Barone F. C., Lysko P. G., Price W. J., Fuerstein G., Albaracanji K. A., Benham C. D., Harrison D. C., Harries M. H., Bailey S. J., Hunter A. J. SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice. Stroke. 26:1995;1683-1689.
2. 2+ antagonist is neuroprotective in two models of ischaemia. Neuropharmacology. 32:1993;1249-1257.
3. Bruno V., Battaglia G., Copani A., Sortino M. A., Canonico P. L., Nicoletti F. Protective action of idebenone against excitotoxic degeneration in cultured neurons. Neurosci. Lett. 178:1994;193-196.
4. Cabaud P. G., Wrobelski F. Colorimetric measurement of lactate dehydrogenase activity of body fluids. Am. J. Clin. Pathol. 30:1958;234.
5. Cai N., Erdo S. L. The effects of kainate and the glutamate agonist, AMPA, are not separable in rat neocortical cultures. Neurosci. Lett. 141:1992;57-60.
6. Cazevielle C., Muller A., Meyner F., Dutrait N., Bonne C. Protection by prostaglandins from glutamate toxicity in cortical neurons. Neurochem. Int. 4:1994;395-398.
7. Choi D. W., Koh J. Y., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J. Neurosci. 8:1988;185-196.
8. Choi D. W., Maulucci-Gedde M., Kriegstein A. R. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7:1987;357-368.
9. Dawson V. L., Dawson T. M., Bartley D. A., Uhl G. R., Snyder S. H. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13:1993;2651-2661.
10. Dawson V. L., Dawson T. M., London E. D., Bredt D. S., Snyder S. H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA. 88:1991;6368-6371.
11. Deupree D. L., Tang X. W., Yarom M., Dickman E., Kirch R. D., Schloss J. V., Wu J.-Y. Studies of NMDA- and non-NMDA-mediated neurotoxicity in cultured neurons. Neurochem. Int. 29:1996;255-261.
12. Farber J. L., Chieu K. R., Mittnacht S. The pathogenesis of irreversible cell injury in ischemia. Am. J. Pathol. 102:1981;271-281.
13. Frandsen A., Drejer J., Schousboe A. Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors. J. Neurochem. 53:1989;297-299.
14. 2+-induced neurotoxicity in primary cortical cultures: Involvement of L-type calcium channels. Brain Res. 654:1994;257-264.
15. Garthwaite G., Garthwaite J. Nitric oxide does not mediate active neurotoxicity, nor is it neuroprotective, in rat brain slices. Neuropharmacology. 33:1994;1431-1438.
16. Goldberg M. P., Choi D. W. Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13:1993;3510-3524.
17. Goldberg M. P., Weiss J. H., Pham P., Choi D. W. N-Methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture. J. Pharmacol. Exp. Ther. 243:1987;784-791.
18. Halliwell R. F., Peters J. A., Lambert J. J. The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: A voltage clamp study on neuronal cells in culture. Br. J. Pharmacol. 96:1989;480-494.
19. Hartley D. M., Choi D. W. Delayed rescue of N-methyl-D-aspartate mediated neuronal injury in cortical culture. J. Pharmacol. Exp. Ther. 250:1989;752-758.
20. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci. 13:1993;1993-2000.
21. Hewett S. J., Muir J. K., Lobner D., Symons A., Choi D. W. Potential of oxygen-glucose deprivation-induced neuronal death after induction of iNOS. Stroke. 27:1996;1586-1591.
22. Kaku D. A., Giffard R. G., Choi D. W. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science. 260:1993;1516-1518.
23. Koh J. Y., Choi D. W. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods. 20:1987;83-90.
24. Koh J. Y., Choi D. W. Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death. Brain Res. 548:1991;318-321.
25. Koh J. Y., Cotman C. W. Programmed cell death: Its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res. 587:1992;233-240.
26. Koh J. Y., Goldberg M. P., Hartley D. M., Choi D. W. Non-NMDA receptor-mediated neurotoxicity in cortical culture. J. Neurosci. 10:1990;693-705.
27. Koretz B., Ahern K. B., Wang N., Lustig H. S., Greenberg D. A. Pre- and post-synaptic modulators of excitatory neurotransmission: Comparative effects on hypoxia/hypoglycemia in cortical cultures. Brain Res. 643:1994;334-347.
28. Kusumoto M., Dux E., Paschen W., Hossman K.-A. Susceptibility of hippocampal and cortical neurons to argon-mediated in vitro ischemia. J. Neurochem. 67:1996;1613-1621.
29. Lippert K., Welsch M., Krieglstein J. Over-additive protective effect of dizocilpine and NBQX against neuronal damage. Eur. J. Pharmacol. 253:1994;207-213.
30. Lustig H. S., von Brauchitsch K. L., Chan J., Greenberg D. A. A novel inhibitor of glutamate release reduces excitotoxic injury in vitro. Neurosci. Lett. 143:1992;229-232.
31. Michaels R. L., Rothman S. M. Glutamate neurotoxicity in vitro: Antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10:1990;283-292.
32. Moudy A. M., Yamada K. A., Rothman S. M. Rapid desensitization determines the pharmacology of glutamate neurotoxicity. Neuropharmacology. 33:1994;953-962.
33. Nozawa M., Toki S., Matsuda Y. The neuroprotective properties of ES-242s, novel NMDA receptor antagonists, in neuronal cell culture toxicity studies. Eur. J. Pharmacol. 236:1993;263-268.
34. Pauwels P. J., Leysen J. E. Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus. Neurosci. Lett. 143:1992;27-30.
35. 2+-mediated neuronal death in rat brain neuronal cultures by veratridine: Protection by flunarizine. Mol. Pharmacol. 36:1989;525-531.
36. 2+ entry blockers prevent glutamate-induced neurotoxicity. Eur. J. Pharmacol. 209:1991;169-173.
37. Prehn J. H. M., Lippert K., Krieglstein J. Are NMDA or AMPA/kainate receptor antagonists more efficacious in the delayed treatment of excitotoxic neuronal injury? Eur. J. Pharmacol. 292:1995;179-189.
38. Priestly T., Horne A. L., McKernan R. M., Kemp J. A. The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures. Brain Res. 531:1990;183-188.
39. Randall R. D., Thayer S. A. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J. Neurosci. 12:1992;1882-1895.
40. Regan R. F., Choi D. W. The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture. Brain Res. 633:1994;236-242.
41. Rothman S. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J. Neurosci. 4:1984;1884-1891.
42. Sheardown M. J., Nielsen E. O., Hansen A. J., Jacobsen P., Honore T. 2,3-D-hydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia. Science. 247:1990;571-574.
43. Simon R. P., Griffith T., Evans M. C., Swan J. H., Meldrum B. S. Calcium overload in selectively vulnerable neurons of the hippocampus during and after ischemia: An electron microscope study in the rat. J. Cereb. Blood Flow Metab. 4:1984;350-361.
44. Uto A., Dux E., Hossman K.-A. Effect of serum on intracellular calcium homeostasis and survival of primary cortical and hippocampal CA1 neurons following brief glutamate treatment. Metab. Brain Dis. 9:1994;333-345.
45. G-nitro-L-arginine of L-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy. Neuroscience. 55:1993;83-901.
46. Weiss J. H., Hartley D. M., Koh J. Y., Choi D. W. The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science. 247:1990;1474-1477.
47. Zinkand W. C., DeFeo P. A., Thompson C., Hargrove H., Salama A. I., Patel J. Quisqualate neurotoxicity in rat cortical cultures: pharmacology and mechanisms. Eur. J. Pharmacol. 212:1992;129-136.