p-hydroxymethamphetamine enantiomer pharmacokinetics and metabolism in rats: Absence of N-demethylation

Biopharmaceutics and Drug Disposition

Volumn 18, Issue 5, 1997, Pages 423-432

  Hutchaleelaha, A ^a,b   Mayersohn, M ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b PFIZER INC   (United States)

Author keywords

N demethylation; P hydroxymethamphetamine; Pharmacokinetics; Stereoselectivity

Indexed keywords

AMPHETAMINE DERIVATIVE; HYDROXYAMPHETAMINE; PHOLEDRINE;

ARTICLE; DEMETHYLATION; DRUG DISPOSITION; DRUG METABOLISM; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY;

ANIMALS; AREA UNDER CURVE; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DEALKYLATION; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; METHAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0030756280     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199707)18:5<423::AID-BDD30>3.0.CO;2-Y     Document Type: Article

References (13)

1. T. Yamamoto, R, Takano, T. Egashira and Y. Yamanaka, Metabolism of methamphetamine, amphetamine and p-hydroxymethamphetamine by rat-liver microsomal preparation in vitro. Xenobiotica, 14, 869-875 (1984).
2. 14c]methamphetamine in man, the guinea pig and the rat. Biochem. J., 129, 11-22 (1972).
3. A. Hutchaleelaha, J. Sukbuntherng, H. H. Chow and M. Mayersohn, Disposition kinetics of D- and L-amphetamine following intravenous administration of racemic amphetamine to rats. Drug Metab. Deposit., 22, 406-411 (1994).
4. A. Hutchaleelaha, Ph. D. Thesis, The University of Arizona (1995).
5. J. Sukbuntherng, A. Hutchaleelaha, H. H. Chow and M. Mayersohn, Separation and quantitation of the enantiomers of methamphetamine and its metabolites in urine by HPLC: precolumn derivatization and fluorescence detection. J. Anal. Texol., 19, 139-147 (1995).
6. M. L. Rocci and W. J. Jusko, LAGRAN program for area and and moments in pharmacokinetic analysis. Comput. Prog. Biomed., 16, 203-216 (1983).
7. H. G. Boxembaum, S. Riegelman and R. M. Elashoff, Statistical estimations in pharmacokinetics. J. Pharmacokinet. Biopharm., 2, 123-148 (1974).
8. F. C. Lam, C. T. Hung and D. G. Perrier, Estimation of variance of harmonic mean half-life. J. Pharm., Sci., 74, 229-231 (1985).
9. T. Ellison, L. Gutzait and E. J. Van Loon, The comparative metabolism of D-amphetamine-C14 in the rat, dog and monkey. J. Pharmacol. Exp. Ther., 152, 383-387 (1966).
10. 14C]amphetamine (paradrine). Biochem. Soc. Trans., 1, 1158-1159 (1973).
11. J. Caldwell, L. G. Dring and R. T. Williams, Biliary excretion of amphetamine and methamphetamine in the rat. Biochem. J., 129, 25-29 (1972).
12. 14C]-amphetamine in rat brain. J. Neurochem., 9, 161-167 (1962).
13. A. Jori and S. Coccia, Distribution of amphetamine and its hydroxylated metabolites in various area of rat brain. J. Pharm. Pharmacol., 26, 746-748 (1974).