Neuroendocrine-specific protein (NSP)-reticulons as independent markers for non-small cell lung cancer with neuroendocrine differentiation: An in vitro histochemical study

Histochemistry and Cell Biology

Volumn 108, Issue 2, 1997, Pages 155-165

  Senden, Nicole ^a   Linnoila, Ilona ^b   Timmer, Erika ^a   Van De Velde, Helgi ^c   Roebroek, Anton ^c   Van De Ven, Wim ^c   Broers, Jos ^a   Ramaekers, Frans ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CALCITONIN; CD57 ANTIGEN; CHROMOGRANIN A; CYTOKERATIN; LAMIN; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; NEUROENDOCRINE SPECIFIC PROTEIN; NEUROFILAMENT PROTEIN; NEURON SPECIFIC ENOLASE; PROTEIN A; RNA; SURFACTANT; VIMENTIN;

ARTICLE; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM; HISTOCHEMISTRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; IN SITU HYBRIDIZATION; LUNG NON SMALL CELL CANCER; NEUROSECRETORY CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; TRANSMISSION ELECTRON MICROSCOPY;

CARCINOMA, NEUROENDOCRINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIFFERENTIATION; ENDOPLASMIC RETICULUM; HISTOCYTOCHEMISTRY; HUMANS; LUNG NEOPLASMS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0030756084     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050157     Document Type: Article

References (51)

1. Abo T, Balch C (1981) A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 127:1024-1029
2. Bepler G, Koehler A, Kiefer P, Havemann K, Beisenherz K, Jaques G, Gropp C, Haeder M (1988) Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines. Differentiation 37:158-171
3. Berendsen HH, Leij L de, Poppema S, Postmus PE, Boes A, Sluiter HJ (1989) Clinical characterization of non-small cell lung cancer tumors showing neuroendocrine differentiation features. J Clin Oncol 7:1614-1620
4. Bridger JM, Kill I, O'Farrell M, Hutchison CJ (1993) Internal lamin structure within G1 nuclei of human dermal fibroblasts. J Cell Sci 104:297-306
5. Broers JLV, Klein Rot M, Oostendorp T, Huysmans A, Wagenaar SSc, Wiersma-Tilburg AJM van, Vooijs G, Ramaekers FCS (1987) Immunocytochemical detection of human lung cancer heterogeneity using antibodies to epithelial, neuronal, and neuroendocrine antigens. Cancer Res 47:3225-3234
6. Broers JLV, Ramaekers FCS, Klein Rot M, Oostendorp T, Huysmans A, Muijen GNP van, Wagenaar SSc, Vooijs GP (1988a) Cytokeratins in different types of human lung cancer as monitored by chain-specific monoclonal antibodies. Cancer Res 48: 3221-3229
7. Broers JLV, Klein Rot M, Oostendorp T, Bepler G, Leij L de, Carney DN, Vooijs GP, Ramaekers FCS (1988b) Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines. J Cell Sci 91:91-108
8. Broers JLV, Mijnheere EP, Klein Rot M, Schaart G, Sijlmans A, Boerman OC, Ramaekers FCS (1991) Novel antigens characteristic of neuroendocrine malignancies. Cancer 67:619-633
9. Broers JLV, Jensen SM, Travis WD, Pass H, Whitsett JA, Singh G, Katyal SL, Gazdar AF, Minna JD, Linnoila RI (1992) Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization. Lab Invest 66: 337-346
10. Broers JLV, Raymond Y, Klein Rot M, Kuijpers H, Wagenaar SSc, Ramaekers FCS (1993) Nuclear A-type lamins are differentially expressed in human lung cancer subtypes. Am J Pathol 143: 211-220
11. Brower M, Carney DN, Oie HK, Gazdar AF, Minna JD (1986) Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Cancer Res 46:798-806
12. Bunn P, Linnoila I, Minna J, Carney D, Gazdar A (1985) Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells. Blood 65:764-768
13. Burke B, Tooze G, Warren G (1983) A monoclonal antibody antibody which recognises each of the nuclear lamin polypeptides in mammalian cells. EMBO J 2:361-367
14. Carbone DP, Koros AMC, Linnoila RI, Jewett P, Gazdar AF (1991) Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenotype and growth morphology. Cancer Res 51:6142-6149
15. Carney DN, Gazdar AF, Bepler G, Guccion JG, Marangos PJ, Moody TW, Zweig MH, Minna JD (1985) Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res 45:2913-2923
16. Deftos LJ, Linnoila RI, Carney DN, Burton DW, Leong SS, O'Connor DT, Murray SS, Gazdar AF (1988) Demonstration of chromogranin A in human neuroendocrine cell lines by immunohistology and immunoassay. Cancer 62:92-97
17. Gazdar AF, Carney DN, Guccion JG, Baylin SB (1981) Small cell carcinoma of the lung: cellular origin and relationship to other pulmonary tumors. In: Greco FA, Oldham RK, Bunn PA (eds) Small cell lung cancer. Grime and Stratton, New York, pp 145-175
18. Gazdar AF, Carney DN, Nau MM, Minna JD (1985) Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties, Cancer Res 45:2924-2930
19. Gazdar AF, Helman LJ, Israel MA, Russell EK, Linnoila I, Mulshine J, Schuller H, Park JG (1988) Expression of neuroendocrine cell markers L-DOPA decarboxylase, chromogranin A and dense core granules in human tumors of endocrine and nonendocrine origin. Cancer Res 48:4078-4082
20. Gazdar AF, Linnoila RI, Hurita Y, Oie HK, Mulshine JL, Clark JC, Whitsett JA (1990) Peripheral airway cell differentiation in human lung cancer cell lines. Cancer Res 50:5481-5487
21. Ginsberg RJ, Kris MG, Armstrong JG (1994) Non-small cell lung cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology. Lippincott, Philadelphia, pp 673-723
22. Graziano SL, Mazid R, Newmann N, Tatum A, Oler A, Mortimer JA, Gullo JJ, DiFino SM, Scalzo AJ (1989) The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small-cell lung cancer. J Clin Oncol 7:1398-1406
23. Graziano SL, Tatum AH, Newman NB, Oler A, Kohman LJ, Veit LJ, Gamble GP, Coleman MJ, Barmada S, O'Lear S (1994) The prognostic significance of neuroendocrine markers and carcinoembryonic antigen in patients with resected stage I and II non-small cell lung cancer. Cancer Res 54:2908-2913
24. Gu J, Linnoila RI, Seibel NL, Gazdar AF, Minna JD, Brooks BJ, Hollis GF, Kirsch IR (1988) A study of myc-related gene expression in small cell lung cancer by in situ hybridization. Am J Pathol 132:13-17
25. Hozák P, Sasseville AM, Raymond Y, Cook PR (1995) Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina. J Cell Sci 108:635-644
26. Ihde DC, Pass HI, Glatstein EJ (1994) Small cell lung cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology. Lippincott, Philadelphia, pp 723-758
27. Jensen SM, Gazdar AF, Cuttitta F, Russell EK, Linnoila RI (1990) A comparison of synaptophysin, chromogranin and L-DOPA decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines. Cancer Res 50:6068-6074
28. Kibbelaar RE, Moolenaar KEC, Michalides RJAM, Bodegom PC van, Vanderschueren RGJRA, Wagenaar SSc, Dingemans KP, Bitter-Suerman D, Dalesio O, Zandwijk N van, Mooi WJ (1991) Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma. Eur J Cancer 27:431-435
29. Klück P, Muijen GNP van, Kamp AWM van der, Tibboel D, Hoorn WA van, Warnaar SO, Molenaar JC (1984) Hirschsprung's disease studied with antineurofilament antibodies on tissue sections. Lancet I:652-654
30. Lan MS, Russell EK, Lu J, Johnson BE, Notkins AL (1993) IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res 53:4169-4171
31. Linnoila RI, Becker KL, Silva OL, Snider RH, Moore CF (1984) Calcitonin as a marker for diethyl-nitrosamine induced pulmonary endocrine cell hyperplasia in hamsters. Lab Invest 51: 39-45
32. Linnoila RI, Mulshine JL, Steinberg SM, Funa K, Matthews MJ, Catelingam JD, Gazdar AF (1988) Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol 90:641-652
33. Linnoila RI, Jensen SM, Steinberg SM, Mulshine JL, Eggleston JC, Gazdar AF (1992) Peripheral airway cell marker expression in non-small cell lung carcinoma. Anat Pathol 97: 233-243
34. Linnoila RI, Piantadosi S, Ruckdeschel JC (1994) Impact of neuroendocrine differentiation in non-small cell lung cancer. Chest (Suppl) 06:367-371
35. Linnoila RI, Aisner SC (1995) Pathology of lung cancer: an exercise in classification. In: Johnson BE, Johnson DH (eds) Lung cancer. Wiley-Liss, New York, pp 73-95
36. Muijen GNP van, Ruiter DJ, Leeuwen C van, Prins FA, Rietsema K, Warnaar SO (1984) Cytokeratin and neurofilament in lung carcinomas. Am J Pathol 116:363-369
37. Påhlman S, Esscher T, Nilsson K (1986) Expression of γ-subunit of enolase, neuron specific enolase in human non-endocrine tumors and derived cell lines. Lab Invest 54:554-560
38. Ramaekers FCS, Huysmans A, Schaart G, Moesker O, Vooijs P (1987) Tissue distribution of keratin 7 as monitored by a monoclonal antibody. Exp Cell Res 170:235-249
39. Roebroek AJM, Velde HJK van de, Bokhoven HJ van, Broers JLV, Ramaekers FCS, Ven WJM Van de (1993) Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product. J Biol Chem 268:13439-13447
40. Senden NHM, Velde HJK Van de, Broers JLV, Timmer EDJ, Roebroek AJM, Ven WJM Van de, Ramaekers FCS (1994a) Cluster 10 lung cancer antibodies recognize NSPs, novel neuroendocrine proteins associated with membranes of the endoplasmic reticulum. Int J Cancer Suppl 8:84-88
41. Senden NHM, Velde HJK Van de, Broers JLV, Timmer EDJ, Kuijpers HJH, Roebroek AJM, Ven WJM Van de, Ramaekers FCS (1994b) Subcellular localization and supramolecular organization of neuroendocrine-specific protein B (NSP-B) in small cell lung cancer. Eur J Cell Biol 65:341-353
42. Senden NHM, Timmer EDJ, Boers JE, Velde HJK Van de, Roebroek AJM, Ven WJM Van de, Broers JLV, Ramaekers FCS (1996) Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A. Eur J Cell Biol 69:197-213
43. Senden NHM, Timmer EDJ, Bruïne A de, Wagenaar SS, Velde HJK van de Roebroek AJM, Ven WJM Van de, Broers JLV, Ramaekers FCS (1997) A comparison of NSP-reticulons with conventional neuroendocrine markers in immunophenotyping of lung cancers. J Pathol 181 (in press)
44. Shaw GL, Gazdar AF, Phelps R, Linnoila RI, Ihde DC, Johnson BE, Oie HK, Pass HI, Steinberg SM, Ghosh BC, Walsh TE, Nesbitt JC, Cotelingham JD, Minna JD, Mulshine JL (1993) Individualized chemotherapy for patients with non-small cell lung cancer determined by prospective identification of neuroendocrine markers and in vitro drug sensitivity testing. Cancer Res 53:5181-5187
45. Skov BG, Sorensen JB, Hirsch FR, Larsson LI, Hansen HH (1991) Prognostic impact of histologic demonstration of chromogranin A and neuron-specific enolase in pulmonary adenocarcinoma. Ann Oncol 2:355-360
46. Stahel RA, Gilks WR, Lehmann HP, Schenker T (1994) Third international workshop on lung tumour and differentiation antigens: overview of the results of the central data analysis. Int J Cancer Suppl 8:6-26
47. Tötsch M, Müller LC, Hittmair A, Offner D, Gibbs A, Schmid KW (1992) Immunohistochemical demonstration of chromogranins A and B in neuroendocrine tumors of the lung. Hum Pathol 23:312-316
48. Velde HJK van de, Roebroek AJM, Senden NHM, Ramaekers FCS, Ven WJM Van de (1994a) NSP-reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum. J Cell Sci 107: 2403-2416
49. Velde HJK van de, Roebroek AJM, Leeuwen FW van, Ven WJM Van de (1994b) Molecular analysis of expression in rat brain of NSP-A. a novel neuroendocrine-specific protein of the endoplasmic reticulum. Mol Brain Res 23:81-92
50. Velde HJK van de, Senden NHM, Roskams TAD, Broers JLV, Ramaekers FCS, Roebroek AJM, Ven WJM Van de (1994c) NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. Cancer Res 54: 4769-4776
51. Zatloukal K, Denk H, Spurej G, Hutter H (1992) Modulation of protein composition of nuclear lamina-reduction of lamins-B1 and lamins-B2 in livers of griseofulvin-treated mice. Lab Invest 66:589-597