Acute and long-term effects of the angiotensin-converting enzyme inhibitor, enalapril, on adrenergic activity and sensitivity during exercise in patients with left ventricular systolic dysfunction

American Heart Journal

Volumn 134, Issue 1, 1997, Pages 37-43

  Patten, R D ^a   Kronenberg, M W ^a   Benedict, C R ^a   Udelson, J E ^a   Kinan, D ^a   Stewart, D ^a   Yusuf, S ^a   Smith, J J ^a   Kilcoyne, L ^a   Dolan, N ^a   Edens, T R ^a   Metherall, J ^a   Konstam, M A ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENALAPRIL; PLACEBO;

ADRENERGIC ACTIVITY; ADULT; ARTICLE; CHRONOTROPISM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DYNAMIC EXERCISE; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE OVERLOAD; HEART RATE; HEART VENTRICLE FUNCTION; HUMAN; MAJOR CLINICAL STUDY; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

EID: 0030755391     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(97)70104-2     Document Type: Article

References (31)

1. JN Cohn The sympathetic nervous system in heart failure J Cardiovasc Pharmacol 14 Suppl 5 1989 S57 S61
2. TB Levine GS Francis SR Goldsmith AB Simon JN Cohn Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure Am J Cardiol 49 1982 1659 1666
3. WN Leimbach BG Wallin RG Victor PE Aylward G Sundlf AL Mark Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure Circulation 73 1986 913 919
4. DW Ferguson WJ Berg JS Sanders Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: evidence from direct microneurographic recordings J Am Coll Cardiol 16 1990 1125 1134
5. MR Bristow R Ginsburg W Minobe RS Cubicciotti WS Sageman K Lurie Decreased catecholamine sensitivity and β adrenergic-receptor density in failing human hearts N Engl J Med 307 1982 205 211
6. AR Denniss JD Marsh RJ Quigg JB Gordon WS Colucci β-Adrenergic receptor number and adenylate cyclase function in denervated transplanted and cardiomyopathic human hearts Circulation 79 1989 1028 1034
7. WS Colucci JP Ribeiro MB Rocco RJ Quigg MA Creager JD Marsh Impaired chronotropic response to exercise in patients with congestive heart failure: role of postsynaptic β-adrenergic desensitization Circulation 80 1989 314 323
8. SR Goldsmith GJ Hasking E Miller Angiotensin II and sympathetic activity in patients with congestive heart failure J Am Coll Cardiol 15 1993 1107 1113
9. RJ Cody KW Franklin J Kluger JH Laragh Mechanisms governing the postural response and baroreceptor abnormalities in chronic congestive heart failure: effects of acute and long-term converting-enzyme inhibition Circulation 66 1982 135 142
10. RJ Cody KW Franklin J Kluger JH Laragh Sympathetic responsiveness and plasma norepinephrine during therapy of chronic congestive heart failure with captopril Am J Med 72 1982 791 797
11. The SOLVD Investigators Studies of left ventricular dysfunction (SOLVD): rationale, design and methods: two trials that evaluate the effect of enalapril in patients with reduced ejection fraction Am J Cardiol 66 1990 315 322
12. The SOLVD Investigators Effect of angiotensin converting enzyme inhibition with enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure: results of the treatment trial of the Studies of Left Ventricular Dysfunction (SOLVD); a randomized double blind trial N Engl J Med 325 1991 293 302
13. The SOLVD Investigators Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions N Engl J Med 327 1992 685 691
14. CR Benedict DE Johnstone DH Weiner MG Bourassa V Bittner R Kay Relation of neurohumoral activation to clinical variables and degree of ventricular dysfunction: a report from the registry of Studies of Left Ventricular Dysfunction J Am Coll Cardiol 23 1994 1410 1420
15. GS Francis C Benedict DE Johnstone PC Kirlin J Nicklas C Liang Comparison of neurohormonal activation in patients with left ventricular dysfunction with and without congestive heart failure: a substudy of the Studies of Left Ventricular Dysfunction (SOLVD) Circulation 82 1990 1724 1729
16. CA Chidsey DC Harrison E Braunwald Augmentation of the plasma norepinephrine response to exercise in patients with congestive heart failure N Engl J Med 267 1962 650 654
17. 1 -receptor downregulation in heart failure Circ Res 59 1986 297 309
18. MR Bristow RE Hershberger JD Port EM Gilbert A Sandoval R Rasmussen β-Adrenergic pathways in nonfailing and failing human ventricular myocardium Circulation 82 Suppl I 1990 I-12 I-25
19. AM Feldman AE Caters WB Veazey RE Hershberger MR Bristow KL Baughman Increase of the 40,000-mol wt pertussis toxin substrate (G-protein) in the failing human heart J Clin Invest 82 1988 189 197
20. M Böhm P Gierschik KH Jakobs P Schnabel B Kemkes E Erdmann Localization of a “postreceptor” defect in human dilated cardiomyopathy Am J Cardiol 64 1989 812 814
21. MA Pfeffer E Braunwald LA Moye L Basta EJ Brown TE Cuddy Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction N Engl J Med 327 1992 669 677
22. The CONSENSUS Trial Study Group Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS) N Engl J Med 316 1987 1429 1435
23. K Swedberg P Eneroth J Kjekshus L Wilhelmsen for the CONSENSUS Trial Study Group Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality Circulation 82 1990 1730 1736
24. JGF Cleland HJ Dargie SG Ball G Gillen GP Hodsman JJ Morton Effects of enalapril in heart failure: a double blind study of effects on exercise performance, renal function, hormones, and metabolic state Br Heart J 84 1985 305 312
25. CR Benedict G Francis B Shelton D Johnstone S Kubo P Kirlin Effect of long-term enalapril therapy on neurohormones in patients with left ventricular dysfunction Am J Cardiol 75 1995 1151 1157
26. EM Gilbert A Sandoval P Larrabee DG Renlund JB O’Connell MR Bristow Lisinopril lowers cardiac adrenergic drive and increases β-receptor density in the failing human heart Circulation 88 1993 472 480
27. BP McGrath LF Arnolda Enalapril reduces the catecholamine response to exercise in patients with heart failure Eur J Clin Pharmacol 30 1986 485 487
28. C Morlin BG Wallin BM Eriksson Muscle sympathetic activity and plasma noradrenaline in normotensive and hypertensive man Acta Physiol Scand 119 1983 117 121
29. GJ Hasking MD Esler GL Jennings E Dewar G Lambert Norepinephrine spillover to plasma during steady-state supine bicycle exercise Circulation 78 1988 521 526
30. IT Meredith G Eisenhofer GW Lambert EM Dewar GL Jennings MD Esler Cardiac sympathetic nervous activity in congestive heart failure: evidence for increased neuronal norepinephrine release and preserved neuronal uptake Circulation 88 1993 136 145
31. PF Binkley GJ Haas RC Starling E Nunziata PA Hatton CV Leier RJ Cody Sustained augmentation of parasympathetic tone with angiotensin converting enzyme inhibition in patients with congestive heart failure J Am Coll Cardiol 21 1993 655 661