Developmental character and long-term consequences of pain in infants and children

Child and Adolescent Psychiatric Clinics of North America

Volumn 6, Issue 4, 1997, Pages 703-724

  Anand, K S ^a   Grunau, R E ^a   Oberlander, T F ^a  

^a BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHILD BEHAVIOR; CHILD DEVELOPMENT; GABAERGIC SYSTEM; MEMORY; NEUROCHEMISTRY; NEUROTRANSMISSION; NOCICEPTION; PAIN; PRIORITY JOURNAL; REVIEW;

EID: 0030754703     PISSN: 10564993     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1056-4993(18)30274-8     Document Type: Review

References (172)

1. Alhaider A.A. Leis Z. Wilcox G.L. Spinal 5-HT3 receptor medicated antinociception Possible release of GABA J Neurosci 11 1991 1881
2. Ader R. Grota L.J. Effects of early experience on adrenocortical reactivity Physiol Behav 4 1969 303
3. Als H. Brazelton T.B. A new model of assessing the behavioral organization in preterm and fullterm infants: Two case studies J Am Acad Child Psychiatry 20 1981 239
4. Anand K.J.S. Analgesia and sedation in ventilated neonates Neonatal Respir Dis 5 1995 1
5. Arland K.J.S. Neonatal stress responses to anesthesia and surgery Clin Perinatol 17 1990 207
6. Anand K.J.S. Relationships between stress responses and clinical outcome in new-borns, infants, and children Crit Care Med 21 1993 358
7. Anand K.J.S. Aynsley-Green A. Measuring the severity of surgical stress in newborn infants J Pediatr Surg 23 1988 297
8. Anand K.J.S. Brown M.J. Causon R.C. Can the human neonate mount an endocrine and metabolic response to surgery? J Pediatr Surg 20 1985 41
9. Anand K.J.S. Carr D.B. The neuroanatomy, neurophysiology and neurochemistry of pain, stress, and analgesia in newborns, infants, and children Pediatr Chin North Am 36 1989 795
10. Anand K.J.S. Craig K.D. Editorial: New perspectives in the definition of pain Pain 66 1996
11. Anand K.J.S. Hickey P.R. Pain and its effects in the human neonate and fetus New Engl J Med 317 1987 1321
12. Anand K.J.S. McGrath P.J. An overview of current issues and their historical background Anand K.J.S. McGrath P.J. Pain in Neonates 1993 Elsevier Science Publishers Amsterdam 1 18
13. Anand K.J.S. McGrath P.J. Future directions Anand K.J.S. McGrath P.J. Pain in Neonates 1993 Elsevier Science Publishers Amsterdam 321 333
14. Andrews K.A. Fitzgerald M. The cutaneous withdrawal reflex in human neonates: Sensitization, receptive fields and the effects of contralateral stimulation Pain 56 1994 95
15. Aslin R.N. Visual and auditory development in infancy Osofsky J.D. Handbook of Infancy, ed 2 1987 John Wiley New York
16. Aynsley-Green A. Pain and stress in infancy and childhood-Where to now? Pediatric Anaesthesia 6 1996 167 172
17. Barr R.G. Pain experience in children: Developmental and clinical characteristics Wall P.D. Melzack R. Textbook of Pain 1994 Churchill Livingstone Edinburgh 739 765
18. Barr R.G. Quek V.S. Cousineau D. Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants Dev Med Child Neural 36 1994 608
19. Basbaum A. Fields H. Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry Ann Rev Neurosci 7 1984 309
20. Beecher H.K. The measurement of pain Pharmacol Rev 9 1957 59
21. Blass E.M. Fitzgerald E. Milk-induced analgesia and comforting in 10-day-old rats: Opioid mediation Pharmacol Biochem Behav 29 1988 9 13
22. Blass E.M. Fillion T.J. Weller A. Separation of opioid from nonopioid mediation of affect in neonatal rates: Nonopioid mechanisms mediate maternal contact influences Behav Neurosci 104 1990 625
23. Blass E.M. Fitzgerald E. Kehoe P. Interactions between sucrose, pain and isolation distress Phar Biochem Behav 26 1987 438
24. Bregman B.S. Development of serotonin immuno-reactivity in the rat spinal cord and its plasticity after neonatal spinal cord lesions Dev Brain Res 34 1987 245
25. Bush J.P. Harkins S.W. Children in Pain: Clinical Issues and Research Issues From a Developmental Perspective 1991 Springer-Verlag New York
26. Bushnell I.V.V.R. Sai F. Mullin J.T. Neonatal recognition of the mother's face Br J Dev Psychol 7 1989 3
27. Caspi A. Henry B. McGee R.O. Temperamental origins of child and adolescent behavior problems: From age three to age fifteen Child Dev 66 1995 55
28. Castro Lopes J.M. Guirimartd N. Harris A. Effects of GABAa and GABAb agonist on a monsynaptic and C-fiber reflex in the rat [abstract] 1996 In Abstracts of the 8th World Congress on Pain, Vancouver British Columbia 355
29. Chan C.W. Dallaire M. Subjective pain sensation is linearly correlated with the flexion reflex in man Brain Res 479 1989 145
30. Chatow U. Davidson S. Reichmart B.L. Development and maturation of the autonomic nervous system in premature and full-term infants using spectral analysis of heart rate fluctuations Pediatr Res 37 1995 294
31. Chay P.C.W. Duffy B.J. Walker J.S. Pharmacokinetic-pharmacodynamic relationships of morphine in neonates Clin Pharmacol Ther 51 1992 334
32. Cook A.J. Woolf C.J. Wall P.D. Dynamic receptive field plasticity in rat spinal cord dorsal horn following C-primary afferent input Nature 325 1987 151
33. Craig K.D. Grunau R.V.E. Neonatal pain perception and behavioral measurement Anand K.J.S. McGrath P.J. Pain in Neonates 1993 Elsevier Science Publishers Amsterdam 67 105
34. Craig KD, Lilley CM, Gilbert CA: Social barriers to optimal pain management in infants and children. Clin J Pain (in press)
35. Craig K.D. Whitfield M.F. Grurtau R.V. Pain in the preterm neonate: Behavioral and physiological indices Pain 52 1993 287
36. Dale J.C. A mutidimensional study of infants' reponses to painful stimuli Pediatr Nurs 12 1986 27
37. DeCasper A.J. Spence M.I. Prenatal maternal speech influences newborns' perception of speech sounds Infant Behav Dev 9 1986 133
38. DeCristofaro J.D. LaGamma E.F. Prenatal exposure to opiates Mental Retardations and Developmental Disabilities Research Reviews 1 1995 177
39. Dixon S. Snyder J. Holye R. Behavioral effects of circumcision with and without anesthesia J Dev Behav Pediatr 5 1984 246
40. Doherty E. Yanni G. Conroy R.M. A comparison of child and parent ratings of disability and pain in juvenile chronic arthritis J Rheumatol 20 1993 1563
41. Emde R.N. Harmon R.J. Metcalf D. Stress and neonatal sleep Psychosom Med 33 1971 491
42. Field T.M. Cohen D. Garcia R. Mother-stranger face discrimination by the newborn Infant Behav Dev 7 1984 19
43. Fiselier T. Monnens L. Moerman E. Influence of the stress of venepuncture on basal levels of plasma renin activity in infants and children Int J Pediatr Nephrol 4 1983 181
44. Jennings E. Fitzgerald M. C-fos can be induced in the neonatal rat spinal cord by both noxious and innocuous peripheral stimulation Pain 68 1996 301
45. Fitzgerald M. C-Fos and the changing face of pain Trends Neurosci 13 1990 439
46. Fitzgerald M. Neurobiology of fetal and neonatal pain Wall P.D. Melzack R. The Textbook of Pain 1994 Churchill Livingstone Edinburgh 153 163
47. Fitzgerald M. Koltzenburg M. The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord Dev Brain Res 24 1986 261
48. Fitzgerald M. Millard C. Mcintosh N. Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia Pain 39 1989 31
49. Fitzgerald M. Shaw A. Macintosh N. Postnatal development of the cutaneous flexor reflex: A comparative study in premature infants and newborn rat pups Dev Med Child Neural 30 1988 520
50. Fitzgerald M. Shortland P. The effect of neonatal peripheral nerve section on the somatodendritic growth of sensory projection cells in the rat spinal cord Dev Brain Res 42 1988 129
51. Fuller B.F.L. Potential acoustic measures of infant pain and arousal Tyler C.D. Krane E.J. Advances in Pain Therapy and Research, vol 15. Pediatric Pain 1990 Raven Press New York 137 145
52. Gilles F.H. Shankle W. Dooling E.C. Myelinated tracts: Growth patterns Gilles F.H. Leviton A. Dooling E.C. The Developing Human Brain 1983 Wright Rz Co Boston 117
53. Gliess J. Stuttgen G. Morphologic and functional development of the skin Stave U. Physiology of the Perinatal Period, vol II. 1970 Appleton-Century-Crofts New York 889
54. Greeley W.J. de Bruijn N.P. Changes in sufentanil pharmacokinetics within the neonatal period Anesth Analg 67 1988 86
55. Green M. Solnit A.J. Reaction to the threatened loss of a child: A vulnerable child syndrome Pediatrics 34 1964 58 66
56. Greenough A. Lagercrantz H. Pool J. Plasma catecholamine levels in preterm infants Acta Pediatr Scartd 76 1987 54
57. Greenough A. Nicolaides K.H. Lagercrantz H. Human fetal sympathoadrenal respon-siveness Early Hum Dev 23 1990 9
58. Greisen G.S. Frederiksen P.S. Hertel M. Catecholamine response to chest physio-therapy and endotracheal suctioning in preterm infants Acta Pediatr Scand 74 1985 525
59. Grunau R.V.E. Craig K.D. Facial activity as a measure of neonatal pain expression Tyler D.C. Krane E.J. Advances in Pain Research Therapy, vol 15 1990 Raven Press New York 147 155
60. Grunau R.V.E. Craig K.D. Pain expression in neonates: Facial action and cry Pain 28 1987 395
61. Grunau R.Y.E. Johnston C.C. Craig K.D. Neonatal facial and cry responses to invasive and non-invasive procedures Pain 42 1990 295
62. Grunau RYE, Whitfield MF, Petrie JH: Children's judgements about pain at age 8-10 years: Do extremely low birthweight (1000) children differ from full birthweight peers? (submitted)
63. Grunau R.Y.E. Whitfield M.F. Petrie J.H. Pain sensitivity and temperament in ex-tremely-low-birthweight premature toddlers and preterm and full-term controls Pain 58 1994 341
64. Grunau R.V.E. Whitfield M.F. Petrie J.H. Early pain experience, child and family factors as precursors of somatization: A prospective study of extremely premature and full-term children Pain 56 1994 353
65. Gunnar M. Connors J. Isensee J. Lack of stability in neonatal adrenocortical reactivity because of rapid habituation of the adrenocortical response Dev Psychobiol 22 1989 221
66. Hack M. Taylor H.G. Klein N. School-age outcomes in children with birth weights under 750 g New Engl J Med 331 1994 753
67. Hadjistavropoulos H.D. Craig K.D. Grunau R.V.E. Judging pain in newborns: Facial and cry determinants J Pediatr Psychol 19 1994 485
68. Haxhija E.Q. Rosegger H. Prechtl H.F. Vagal response to feeding tube insertion in preterm infants: Has the key been found? Early Hum Dev 41 1995 15
69. Herzog J.M. The Neonatal Intensive Care Syndrome: A pain complex involving neuroplasticity and psychic trauma Call J.D. Galenson E. Tyson R.L. Frontiers of Infant Psychiatry 1983 Basic Books New York 291 300
70. Hindle A.T. Recent developments in the physiology and pharmacology of 5-hydroxytryptamine Br J Anaesth 73 1994 395
71. Huether G. Thomke F. Adler L. Administration of trytophan-enriched diets to pregnant rats retards the development of the serotonergic system in their offspring Brain Res 68 1992 175
72. Humphrey T. Some correlations between the appearance of human fetal reflexes and the development of the nervous system Prog Brain Res 4 1964 93
73. Jacquin M.F. Renehan W.E. Klein B.G. Functional consequences of neonatal infraorbital nerve section in rat trigeminal ganglion J Neurosci 6 1986 3706
74. Jemmott J.B. Locke S.E. Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: How much do we know? Psychol Bull 95 1984 78
75. Johnston C.C. Stevens B.J. Experience in a neonatal intensive care unit affects pain response Pediatrics 98 1996 925
76. Johnston C.C. Stevens B.J. Craig K.D. Developmental changes in pain expression in premature, full-term, two- and four-month-old infants Pain 52 1993 201
77. Johnston C.C. Stevens B.J. Yang F. Developmental changes in response to heelstick in preterm infants: A prospective cohort study Dev Med Child Neurol 38 1996 438
78. Johnston C.C. Strada M.E. Acute pain responses in infants: A multidimensional description Pain 24 1986 373
79. Kaas J.H. Merzenich M.M. Killackey H.P. The reorganization of somatosensory cortex following peripheral nerve damage in adult developing mammals Annu Rev Neu-rosci 6 1983 325
80. Kaneko M. Hammond D.L. GABA acting at GABAa receptors in the spinal cord limits the second, but not the first phase response to formalin in the rat [abstract] 1996 In Abstracts of the 8th World Congress on Pain, Vancouver British Columbia 245
81. Killackey H.P. Dawson D.R. Expansion of the central hindpaw representation follow-ing fetal forelimb removal in the rat Eur J Neurosci 1 1989 210
82. Kinney H.C. Ottoson C.K. White V.V.F. Three-dimensional distribution of 3H-naloxone binding to opiate receptors in the human fetal and infant brainstem J Comp Neurol 291 1990 55
83. Klebanov P.K. Brooks-Gunn J. McCormick M.C. School achievement and failure in very low birth weight children Pediatrics 15 1994 248
84. Klebanov P.K. Brooks-Gunn J. McCormick M.C. Classroom behaviour of very low birth weight elementary school children Pediatrics 94 1994 700
85. Korner A.F. Stevenson D.K. Forrest T. Preterm medical complications differen-tially affect neurobehavioral functions: Results from a new neonatal medical index Infant Behav Dev 17 1994 37
86. Lagercrantz H. Nilsson E. Redham I. Plasma catecholamines following nursing procedures in a neonatal ward Early Hum Dev 14 1986 61
87. Landfield P.W. McEwan B.S. Sapolsky R.M. Hippocampal cell death Science 272 1996 1249
88. Lauder J.M. Neurotransmitters as growth regulatory signals: Role of receptors and second messengers Trends Neurosci 16 1993 233
89. Lauder J.M. Ontogeny of neurotransmitter systems: Substrates for developmental disabilities? Mental Retardation and Developmental Disabilities Research Reviews 1 1995 151
90. Lauder J.M. Han V.K. Henerson P. Prenatal ontogeny of the GABAergic system in the rat brain Neuroscience 19 1986 465
91. Lauer J.A. Adams P.M. Johnson K.M. Perinatal diazepam exposure: Behavioral and neurochemical consequences Neurotoxicol Teratol 9 1987 213
92. Levine J.D. Gordon N.C. Pain in pre-lingual children and its evaluation by paininduced vocalisation Pain 14 1982 85
93. Levine S. Infantile experience and resistance to physiological stress Science 126 1957 405
94. Levine S. Plasma-free corticosteroid response to electric shock in rats stimulated in infancy Science 135 1962 795
95. Levine S. Haltmeyer G.C. Karas G.G. Physiological and behavioral effects of infantile stimulation Physiol Behav 2 1967 55
96. Leviton A. Preterm birth and cerebral palsy: Is tumour necrosis factor the missing link? Dev Med Child Neural 35 1993 553
97. Levy D.M. The infant's earliest memory of inoculation: A contribution to public health procedures J Genet Psychol 96 1960 3
98. Lewis M. Thomas D. Cortisol release in infants responding to inoculation Child Dev 61 1990 50
99. Lilley CM, Craig KO, Grunau RE: The expression of pain in infants and toddlers: Developmental changes in facial action. Pain, in press
100. Low J.A. Froese A.B. Smith J.T. Hypotension and hypoxemia in the preterm newborn during the four days following delivery identify infants at risk of echosono-graphically demonstrable cerebral lesions Chin Invest Med 15 1992 60
101. Marine S.L. Jacobsen P.B. Redd W.H. Assessment of acute pediatric pain Do child self-report, parent ratings, and nurse ratings measure the same phenomenon? Pain 48 1992 45
102. Marlow N. Roberts L. Cooke R. Outcome at eight years for children with birth weights of 1250 g or less Arch Dis Child 68 1993 286
103. Marti E. Gibson S.J. Polak J.M. Ontogeny of peptide- and amine-containing neurones in motor, sensory and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin J Comp Neurol 266 1987 332
104. McEwen B.S. The plasticity of the hippocampus is the reason for its vulnerability Neuroscience 6 1994 239
105. McGrath P.A. Pain in Children: Nature, Assessment and Treatment 1990 The Guilford Press New York
106. McGrath P.J. Unruh A.M. Pain in Children and Adolescents Amsterdam 1987 Elsevier Science Publications
107. McIntosh N. Pain in the newborn, a possible new starting point Eur J Pediatr 156 1997 173
108. Meaney M.J. Sharma S. Sarrieau S. Postnatal development and environmental regulation of hippocampal glucocorticoid and mineralocorticoid receptors in the rat Dev Brain Res 43 1988 158
109. Meaney M.J. Tannenbaum B. Bhatnagar S. Early environmental programming hypothalmic-pituitary-adrenal responses to stress Neuroscience 6 1994 247
110. Melzack R. Wall P.D. Evolution of pain theories Wall P.D. Melzack R. Textbook of Pain 1994 Churchill Livingstone Edinburgh 3 34
111. Merskey H. Classification of chronic pain: Descriptions of chronic pain syndromes and definitions of pain terms Pain 3 1986 51
112. Michelsson K. Jarvenpaa A.L. Rinne A. Sound spectrographic analysis of pain cry in preterm infants Early Hum Dev 8 1983 141
113. Miller A. Barr R.G. Young S.N. The cold pressor test in children: Methodological aspects and the analgesic effect of intraoral sucrose Pain 56 1994 175
114. Mouradian L.E. Als H. The influence of neonatal intensive care unit careg1vmg practices on motor functioning of preterm infants Am J Occup Ther 48 1994 527
115. Neveu P.J. Deleplanque B. Puglisi-Allegra S. Influence of early life events on immune reactivity in adult male mice Dev Psychobiol 27 1994 205
116. Nussbaumer J.-C. Yanagisawa M. Otsuka M. Pharmalogical properties of a C-fibre response evoked by saphenous nerve stimulation in an isolated spinal cord-nerve preparation of the newborn rat Br J Pharmacol 98 1989 373
117. Nuwayhid B. Brinkman C.R. Su C. Development of autonomic control of fetal circulation Am J Physiol 228 1975 337
118. Oberlander TF, Barr RG, Young SN: The pharmologic effects of meal composition on acute pain in the newborn period. (manuscript under review)
119. Panneton R.K. Prenatal auditory experience with melodies: Effects on postnatal auditory preferences in human newborns Unpublished doctoral dissertation 1985 University of North Carolina Greensboro
120. Peng Y.B. Ling Q. Willis W.D. Modulation of periaqueductal grey-induced inhibition of spinal dorsal horn neurons: Role of GABA and glycine [abstract] 1996 In Abstracts of the 8th World Congress on Pain, Vancouver British Columbia 474
121. Perlman J. Thach B. Respiratory origin of fluctuations in arterial blood pressure in premature infants with respiratory distress syndrome Pediatrics 81 1988 399
122. Pharoah P.O.D. Stevenson C.J. Cooke R.W.I. Clinical and subclinical deficits at eight years in a geographically defined cohort of low birth weight infants Arch Dis Child 70 1994 264
123. Pharoah P.O.D. Stevenson C.J. Cooke R.W.L. Prevalence of behaviour disorders in low birthweight infants Arch Dis Child 70 1994 271
124. Philbin M.K. Ballweg D.D. Gray L. The effect of an intensive care unit sound environment on the development of habituation in health avian neonates Dev Psychobiol 27 1994 11
125. Pieretti S. d'Amore A. Loizzo A. Long-term changes induced by developmental handling on pain threshold: Effects of morphine and naloxone Behav Neurosci 105 1991 215
126. Pignatelli D. Ribeiro-Silva A. Coimbra A. Onset of synapse formation in the human spinal cord Brain Res 491 1989 33
127. Pinto-Martin J.A. Riolo S. Cnaan A. Cranial ultrasound prediction of disabling and nondisabling cerebral palsy at age two in a low birth weight population Pediatrics 95 1995 249
128. Plotsky P.M. Meaney M.J. Early, postnatal experience alters hypothalmic corticotro-pin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats Mol Brain Res 18 1993 195
129. Pokela M.L. Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures Pediatrics 93 1994 379
130. Porter F.L. Miller R.H. Marshall R.E. Neonatal pain cries: Effect of circumcision on acoustic features and perceived urgency Child Dev 57 1986 790
131. Porter F.L. Porges S.W. Marshall R.E. Newborn pain cries and vagal tone: Parallel changes in response to circumcision Child Dev 59 1988 495
132. Ramaekers V.T. Casaer P. Daniels H. Cerebral hyperperfusion following episodes of bradycardia in the preterm infant Early Hum Dev 34 1993 199
133. Ramenghi L.A. Wood C.H. Griffith G.C. Reduction of pain response in premature infants using intraoral sucrose Arch Dis Child 74 1996 126
134. Ramsay D.S. Lewis M. The effects of birth condition on infants' cortisol response to stress Pediatrics 95 1995 546
135. Reynolds M.L. Fitzgerald M. Long-term sensory hyperirmervation following neonatal skin wounds J Comp Neurol 358 1995 487
136. Richards M.P. Bernal J.F. Brackbill Y. Early behavioral differences: Gender or circum-cision? Dev Psychobiol 9 1976 89
137. Rosenblith J.F. In the Beginnings 1992 Sage London
138. Ross D.M. Ross S.A. Childhood Pain: Current Issues, Research, and Management 1988 Baltimore-Munich Urban & Schwarzenberg
139. Rovee-Collier C. The 'memory system' of pre-linguistic infants Ann N Y Acad Sci 608 1990 517 542
140. Rushforth J.A. Griffiths G. Thorpe H. Can topical lignocaine reduce behavioural response to heel prick? Arch Dis Child 72 1995 49
141. Rushforth J.A. Levene M.I. Behavioral response to pain in healthy neonates Arch Dis Child 70 1994 174
142. Saigal S. Szatmari P. Rosenbaum P. Cognitive abilities and school performance of extremely low birth weight children and matched term control children at age 8 years: A regional study J Pediatr 118 1991 751
143. Satoh O. Oainote K. Kanamata M. Monaminergic and gabaergic modulation in pathological pain following peripheral nerve constriction injury [abstract] 1996 Abstracts of the 8th World Congress on Pain, Vancouver British Columbia 468
144. Shanks N. Larocque S. Meaney M.J. Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: Early illness and later responsivity to stress J Neurosci 15 1995 376
145. Schecter N.L. Berde C.B. Yaster M. Pain in infants, children, and adolescents: An overview Schecter N.L. Berde C.B. Yaster M. Pain in Infants, Children and Adolescents 1993 Williams and Wilkins Baltimore 3 19
146. Shemer A. Whitaker-Azmitia P.M. Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat Pharmacol Biochem Behav 30 1988 847
147. Smith D. Gallage R. GABA D. benzodiazepine and serotonergic receptor development in the dorsal raphe nucleus: Electrophysiological studies Dev Brain Res 35 1987 191
148. Stevens B.J. Johnston C.C. Horton L. Factors that influence the behavioral pain responses in premature infants Pain 59 1994 101
149. Stifter C.A. Fox N.A. Infant reactivity: Physiological correlates of newborn and five-month temperament Dev Psychol 26 1990 582
150. Stifter C.A. Fox N.A. Porgus S.W. Facial expressivity and heart rate variability in five-and ten-month-old infants Infant Behav Dev 12 1989 127
151. Stifter C.A. Jain A. Psychophysiological correlates of infant temperament: Stability of behavior and autonomic patterning from 5 to 18 months Dev Psychobiol 29 1996 379
152. Taddio A. Katz J. Ilersich A.L. Effect of neonatal circumcision on pain response during subsequent routine vaccination Lancet 349 1997 599
153. Teplin S.W. Burchinal M. Johnson M.N. Neurodevelopmental, health, and growth status at age six years of children with birth weights less than 1001 grams J Pediatr 118 1991 768
154. Verloove-Vanhorick S.P. School performance in very preterm infants The Lancet 342 1993 550
155. Volpe I.I. Neurology of the Newborn 1995 WB Saunders Philadelphia
156. Wako G.A. Cassidy R.C. Schechter N.L. Pain, hurt, and harm: The ethics of pain control in infants and children New Engl J Med 331 1994 541
157. Wall P.D. Stability and instability of central pain mechanisms Dubner R. Gebhart G.F. Bond M.R. Proceedings of the Fifth World Congress on Pain 1988 Elsevier Science Amsterdam 13
158. Wasz-Hockert O. Lind J. Vuorenkoski V. The infant cry: A spectrographic and auditory analysis Clin Dev Med 2 1968 9
159. Whitaker-Azmitia P.M. Druse M. Walker P. Serotonin as a developmental signal Behav Brain Res 73 1996 19
160. Whitfield MF, Grunau RVE, Holsti L: Extreme prematurity (800g) at school age: Multiple areas of hidden disability. Arch Dis Child, 1997
161. Wiertelak E.P. Smith K.P. Furness L. Acute and conditioned hyperalgesic responses to illness Pain 56 1994 227
162. Willer J.C. Comparative study of perceived pain and nociceptive flexion reflex in man Pain 3 1977 69
163. Willer J.C. Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man Brain Res 331 1985 105
164. Willer J.C. Bussell B: Evidence for a direct spinal mechanism in morphine-induced inhibition of nociceptive reflexes in man Pain 3 1980 69
165. Williams S. Evan G. Hunt S.P. Spinal c-fos induction by sensory stimulation in neonatal rats Neurosci Lett 109 1990 309
166. Woolf C.H. Wall P.D. Morphine-sensitive and morphine-insensitive actions of C-fibre input on the rat spinal cord Neurosci Lett 64 1986 221
167. Yanagisawa M. Murakoshi T. Tamai S. Tail pinch method in vitro and the effects of some antinociceptive compounds Eur J Pharmacol 106 1985 231
168. Yaster M. The dose response of fentanyl in neonatal anesthesia Anesthesiology 66 1987 433
169. Yi D.K. Barr G.A. The induction of fos-like immunoreactivity by noxious thermal, mechanical and chemical stimuli in the lumbar spinal cord of infant rats Pain 60 1995 257
170. Zernikow B. Michel E. Kohlmann G. Cerebral autoregulation of preterm neonates-a non-linear control system? Arch Dis Child 70 1994 166
171. Zeskind P.L. Sale J. Adult perceptions of pain and hunger cries: A synchrony of arousal Child Dev 56 1985 549
172. Zupan V. Gonzalez P. Lacaze-Masmonteil T. Periventricular Leukomalacia: Risk factors revisited Dev Med Child Neural 38 1996 1061