Insulin receptors in mouse brain: Age-related modifications are corrected by thymus graft

Mechanisms of Ageing and Development

Volumn 98, Issue 1, 1997, Pages 37-46

  Zaia, Annamaria ^a   Piantanelli, Lucio ^a  

^a INRCA   (Italy)

Author keywords

Aging impairment reversibility; Brain insulin receptors; Endocrine thymus; Mouse

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; INSULIN RECEPTOR; RECEPTOR SUBTYPE;

ADRENERGIC SYSTEM; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; KIDNEY CAPSULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; THYMUS GRAFT;

AGING; ANIMALS; BRAIN; HUMANS; MICE; MICE, INBRED BALB C; RECEPTOR, INSULIN; THYMUS GLAND; TISSUE TRANSPLANTATION;

ANIMALIA;

EID: 0030752942     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(97)00066-3     Document Type: Article

References (59)

1. J. Havrankova, D. Schmechel, J. Roth, M.J. Brownstein, Identification of insulin in rat brain, Proc. Natl. Acad. Sci. USA 75 (1978) 5737-5741.
2. J. Havrankova, J. Roth, M.J. Brownstein, Insulin receptors are widely distributed in the central nervous system of the rat, Nature 272 (1978) 827-829.
3. J.M. Hill, M.A. Lesniak, C.B. Pert, J. Roth, Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and lymbic areas, Neuroscience 17 (1986) 1127-1138.
4. S. Gammeltoft, P. Staun-Olsen, B. Ottesen, J. Fahrenkrug, Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system, Peptides 5 (1984) 937-944.
5. W.S. Young III, M.J. Kuhar, J. Roth, M.J. Brownstein, III Radiohistochemical localization of insulin receptors in the adult and developing rat brain, Neuropeptides 1 (1980) 15-22.
6. Y. Oomura, H. Kita, Insulin acting as a modulator of feeding through the hypothalamus, Diabetologia 20 (1981) 290-298.
7. S.C. Woods, E.C. Looter, L.D. Mc Kay, D. Porte Jr., Chronic intracerebroventricular infusion of insulin reduces food intake and body weight in baboons, Nature 282 (1979) 503-505.
8. M.K. McGowan, K.M. Andrews, S.P. Grossman, Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat, Physiol. Behav. 51 (4) (1992) 753-766.
9. M. Barbaccia, D. Chuang, E. Costa, Is insulin a neuromodulator?, Adv. Biochem. Psychopharmacol. 33 (1982) 511-518.
10. T. Hokfelt, O. Johansson, A. Ljungdahl, J.M. Lundberg, M. Schultzberg, Peptidergic neurons, Nature 284 (1980) 515-521.
11. C.C. Yip, M.L. Moule, C.W.T. Yeung, Characterization of insulin receptor subunits in brain and other tissues by photoaffinity labeling, Biochem. Biophys. Res. Commun. 96 (1980) 1671-1678.
12. K.A. Heidenreich, N.R. Zahniser, P. Berhanu, D. Brandenburg, J.M. Olefsky, Structural differences between insulin receptors in the brain and peripheral target tissues, J. Biol. Chem. 258 (1983) 8527-8530.
13. K.A. Heidenreich, D. Brandenburg, Oligosaccharide heterogeneity of insulin receptors. Comparison of N-linked glycosylation of insulin receptors in adipocytes and brain, Endocrinology 118 (1986) 1835-1842.
14. N.R. Zahniser, M.B. Goens, P.J. Hanaway, J.V. Vinyeh, Characterization and regulation of insulin receptors in rat brain, J. Neurochem. 42 (1984) 1353-1362.
15. M.K. Raizada, F.T. Boyd, D.W. Clarke, D. Le Roith, Physiologically unique insulin receptors on neuronal cells, in: M.K. Raizada, M.I. Phillips, D. LeRoith (Eds.), Insulin, Insulin-like Growth Factors and their Receptors in the Central Nervous System, Plenum, New York, 1987, pp. 191-200.
16. A. Zaia, L. Piantanelli, Insulin receptors in the brain: age-related modifications, in: A. Viidik, G. Hofecker (Eds.), Vitality, Mortality and Aging, vol. 5, Facultas Universitatsverlag, Wien, 1996, pp. 147-158.
17. A. Zaia, L. Piantanelli, Alterations of brain insulin receptor characteristics in aging mice, Arch. Gerontol. Geriatr. 23 (1996) 27-37.
18. D.W. Clarke, F.T. Boyd Jr., M.S. Kappy, M.K. Raizada, Insulin binds to specific receptors and stimulates 2-deoxy-d-glucose uptake in cultured glial cells from rat brain, J. Biol. Chem. 259 (1984) 11672-11675.
19. D.W. Clarke, F.T. Boyd, M.S. Kappy, M.K. Raizada, Insulin stimulates macromolecular synthesis in cultured glial cells from rat brain, Am. J. Physiol. 249 (1985) C484-C489.
20. F.T. Boyd Jr., D.W. Clarke, T.F. Muther, M.K. Raizada, Insulin receptors and modulation of norepinephrine uptake by insulin in neuronal cells in culture, J. Biol. Chem. 260 (1985) 15880-15884.
21. F.T. Boyd Jr., M.K. Raizada, Effects of insulin and tunicamycin on neuronal insulin receptors in culture, Am. J. Physiol. 245 (1983) C283-C287.
22. W.L. Lowe, F.T. Boyd, D.W. Clarke, M.K. Raizada, C. Hart, D. Le Roith, Development of brain insulin receptors: structural and functional studies of insulin receptors from whole brain and primary cell cultures, Endocrinology 119 (1986) 2535.
23. A. Sauter, M. Goldstein, J. Engel, K. Ueta, Effect of insulin on central catecholamines, Brain Res. 260 (1983) 330-333.
24. P.J. Scarpace, Decreased β-adrenergic responsiveness during senescence, FASEB J. 45 (1986) 51-54.
25. G.S. Roth, Age changes in adrenergic and dopaminergic signal transduction mechanisms: parallels and contrasts, Neurobiol. Aging 9 (1988) 63-64.
26. A. Zaia, C. Viticchi, L. Piantanelli, Differential regulation of brain, β-adrenoceptor subpopulations in aging rodents, Ann. New York Acad. Sci. 673 (1992) 200-205.
27. G. Rossolini, C. Viticchi, A. Zaia, A. Basso, L. Piantanelli, Thymus-induced recovery of age-related decrease of brain cortex α- and β-adrenoceptors, Int. J. Neurosci. 59 (1991) 143-150.
28. C. Viticchi, D. Bulian, W. Pierpaoli, L. Piantanelli, Brain cortex α- and β-adrenoceptors are differentially modulated by pineal graft in aging mice, Ann. New York Acad. Sci. 719 (1994) 448-453.
29. C. Viticchi, L. Piantanelli, F. Rossano, N.H. Spector, Age-related regulation of mouse brain cortex adrenoceptors following camphor vapor exposition, Arch. Gerontol. Geriatr. 23 (1996) 39-46.
30. C. Viticchi, S. Gentile, L. Piantanelli, Aging and thymus-induced differential regulation of β-1 and β-2 adrenoceptors of mouse brain cortex, Arch. Gerontol. Geriatr. 8 (1989) 13-20.
31. P. Fattoretti, C. Viticchi, L. Piantanelli, Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the thymus, Arch. Gerontol. Geriatr. 1 (1982) 229-235.
32. C. Viticchi, L. Piantanelli, Thymus and age modulate the beta-adrenergic mediated adenylate cyclase activity in brain cortex of mice, in: E. Bergamini (Ed.), Protein Metabolism in Aging, Wiley-Liss, New York, 1990, pp. 325-329.
33. C. Pieri, C. Giuli, M. Del Moro, L. Piantanelli, Electron-microscopic morphometric analysis of mouse liver. II. Effect of ageing and thymus transplantation in old animals, Mech. Ageing Dev. 14 (1980) 155-165.
34. C. Pieri, C. Giuli, C. Bertoni-Freddari, L. Piantanelli, I.Z. Nagy, Thymic control on the polyploidization of hepatocytes during aging, Experientia 38 (1982) 680-681.
35. O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
36. 2+ in the regulation of hormone receptor exposure during lymphocyte activation, Biochim. Biophys. Acta 983 (1989) 153-160.
37. R.A. Roth, Bacitracin: an inhibitor of the insulin degrading activity of glutathione-insulin transhy-drogenase, Biochem. Biophys. Res. Commun. 98 (1981) 431-438.
38. P.J. Munson, D. Rodbard, Ligand: a versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107 (1980) 220-239.
39. A. Zaia, L. Piantanelli, Assay of insulin receptors in mouse brain, J. Biol. Res. 72 (3-4) (1996) 95-102.
40. L. Piantanelli, N. Fabris, Hypopituitary dwarf and athymic nude mice and the study of the relationships among thymus hormones and aging, 69n: D.E. Harrison (Ed.), Genetic Effects on Aging. Birth Defects, Original Article Series, A.R. Liss, vol. XIV n.1, New York, 1978, pp. 315-333.
41. W. Pierpaoli, E. Sorkin, Alterations of adrenal cortex and thyroid in mice with congenital absence of thymus, Nature New Biol. 238 (1972) 501.
42. J. Comsa, E.M. Phillip, H. Leonhardt, Effect of thymectomy on the endocrine glands of the rat, Isr. J. Med Sci. 13 (1977) 354.
43. R.W. Rebar, Effects of thymic peptides on hypothalamic-pituitary function, in: A.L. Goldstein (Ed.), Thymic Hormones and Lymphokines, Basic Chemistry and Clinical Applications, Plenum, New York, 1984, pp. 325-334.
44. N.F. Cardarelli, The thymus as an endocrine gland: early studies, in: N.F. Cardarelli (Ed.), The thymus in Health and Senescence. Thymus and Immunity, vol. 1, CRC Press, Boca Raton, FL, 1989, pp. 59-70.
45. D.L. Healy, N.R. Hall, H.M. Schulte eyt al., Pituitary responses to acute administration of thymosin and to thymectomy in prepubertal primates, in: A.L. Goldstein (Ed.), Thymic Hormones and Lymphokines, Basic Chemistry and Clinical Applications, Plenum, New York, 1984, pp. 365-374.
46. E.W. Palaszynski, T.W. Moody, T.L. O'Donobue, A.L. Goldstein, Thymosine alpha 1-like peptides: localization and biochemical characterization in the brain and pituitary gland, Peptides 4 (1985) 463.
47. T. Brink-Johnson, T.F. Dougherty, Effect of cortisol and corticotropin on incorporation of adenine in the lymphatic tissue nucleic acids, Acta Endocrinol. 49 (1965) 471.
48. S. Arrenbrecht, Specific binding of growth hormone to thymocytes, Nature 252 (1974) 255-257.
49. K. Bullock, R.Y. Moore, Innervation of the thymus gland by brainstem and spinal cord in mouse and rat, Ann. J. Anat. 163 (1981) 157.
50. M.P. Dabrowski, B.K. Dabrowska-Bernstein, Thymus and neuro-endocrine immune regulation of homeostasis, in: M.P. Dabrowski, B.K. Dabrowska-Bernstein (Eds.), Immunoregulatory Role of Thymus, CRC Press, Boca Raton, FL, 1990, pp. 97-127.
51. L. Piantanelli, A. Basso, M. Muzzioli, N. Fabris, Thymus-dependent reversibility of physiological and Isoproterenol-evoked age-related parameters in athymic (nude) and old normal mice, Mech. Ageing Dev. 7 (3) (1978) 171-182.
52. C. Viticchi, L. Piantanelli, Aging and thymus modulate the beta-adrenergic responsiveness in the brain cortex of mice, in: L. Roberts, G. Hofecker (Eds.), The Theoretical Basis of Aging Research, Facultas Verlag, Wien, 1990, pp. 259-264.
53. C. Giuli, C. Pieri, L. Piantanelli, N. Fabris, Electron microscopic morphometric analysis of mouse liver. I. Experimental studies on the morphogenetic significance of the thymus in nude and normal mice, Mech. Ageing Dev. 13 (1980) 265-274.
54. F.T. Boyd Jr., D.W. Clarke, M.K. Raizada, Insulin inhibits specific norepinephrine uptake in neuronal cultures from rat brain, Brain Res. 398 (1986) 1-5.
55. R.A. Palovcik, M.I. Phillips, M.S. Kappy, M.K. Raizada, Insulin inhibits pyramidal neurons in hippocampal slices, Brain Res. 309 (1984) 187-191.
56. 1-adrenergic activity in the rat hyppocampus, Brain Res. 550 (1991) 101-107.
57. E.M. Richards, M.K. Raizada, C. Sumners, Insulin downregulates alpha-2 adrenergic receptors in cultured glial cells, in: M.K. Raizada, M.I. Phillips, D. LeRoith (Eds.), Insulin, Insulin-Like Growth Factors and their Receptors in the Central Nervous System, Plenum, New York, 1987, pp. 209-214.
58. B.J. Wilcox, A.M. Matsumoto, D.M. Dorsa, D.G. Baskin, Reduction of insulin binding in the arcuate nucleus of the rat brain after 6-hydroxydopamine treatment, Brain Res. 500 (1989) 149-155.
59. M.I. Phillips, Insulin in the brain: a feedback loop involving brain insulin and circumventricular organs, in: M.K. Raizada, M.I. Phillips, D. LeRoith (Eds.), Insulin, Insulin-Like Growth Factors, and their Receptors in the Central Nervous System, Plenum, New York, 1987, pp. 163-175.