Combined non-enzymatic and enzymatic reduction favors bioactivation of racemic lipoic acid: An advantage of a racemic drug?

Chirality

Volumn 9, Issue 4, 1997, Pages 362-366

  Biewenga, Gerreke Ph ^a,b   Haenen, Guido R M M ^a   Groen, Brenda H ^c   Biewenga, Jeike E ^a   Van Grondelle, Rienk ^c   Bast, Aalt ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Antioxidant; Dihydrolipoamide dehydrogenase; Enantiomers; Lipoic acid; Reduction

Indexed keywords

DIHYDROLIPOAMIDE DEHYDROGENASE; DIHYDROLIPOATE; THIOCTIC ACID;

ANTIOXIDANT ACTIVITY; ARTICLE; CATALYST; CIRCULAR DICHROISM; DRUG ACTIVITY; ENZYME ACTIVITY; GLYCATION; PRIORITY JOURNAL; RACEMIC MIXTURE; REDUCTION;

EID: 0030752894     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:4<362::AID-CHIR8>3.0.CO;2-F     Document Type: Article

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