Body composition and physical fitness are major determinants of the growth hormone-insulin-like growth factor axis aberrations in adult Turner's syndrome, with important modulations by treatment with 17β-estradiol

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 8, 1997, Pages 2570-2577

  Gravholt, Claus Højbjerg ^a   Naeraa, Rune Weis ^a   Fisker, Sanne ^a   Christiansen, Jens Sandahl ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ESTRADIOL; GAMMA GLUTAMYLTRANSFERASE; GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; LIVER ENZYME; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN; SOMATOMEDIN B;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FITNESS; GROWTH HORMONE RELEASE; HORMONE SUBSTITUTION; HUMAN; LIVER FUNCTION; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TRANSDERMAL DRUG ADMINISTRATION; TURNER SYNDROME;

ADULT; AGING; BODY COMPOSITION; CARRIER PROTEINS; ESTRADIOL; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; KARYOTYPING; LIVER; OXYGEN CONSUMPTION; PHYSICAL FITNESS; TREATMENT OUTCOME; TURNER SYNDROME;

EID: 0030752864     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.8.2570     Document Type: Article

References (56)

1. Massarano AA, Brook CG, Hindmarsh PC, et al. 1989 Growth hormone secretion in Turner's syndrome and influence of oxandrolone and ethinyl oestradiol. Arch Dis Child. 64:587-592.
2. Reiter JC, Craen M, Van Vliet G. 1991 Decreased growth hormone response to growth hormone-releasing hormone in Turner's syndrome: relation to body weight and adiposity. Acta Endocrinol (Copenh). 125:38-42.
3. Veldhuis JD, Sotos JF, Sherman BM. 1991 Decreased metabolic clearance of endogenous growth hormone and specific alterations in the pulsatile mode of growth hormone secretion occur in prepubertal girls with Turner's syndrome. Genentech Collaborative Group. J Clin Endocrinol Metab. 73:1073-1080.
4. Ranke MB, Blum WF, Haug F, et al. 1987 Growth hormone, somatomedin levels and growth regulation in Turner's syndrome. Acta Endocrinol (Copenh). 116:305-313.
5. Saenger P, Schwartz E, Wiedemann E, Levine LS, Tsai M, New MI. 1976 The interaction of growth hormone, somatomedin and oestrogen in patients with Turner's syndrome. Acta Endocrinol (Copenh). 81:9-18.
6. Wit JM, Massarano AA, Kamp GA, et al. 1992 Growth hormone secretion in patients with Turner's syndrome as determined by time series analysis. Acta Endocrinol (Copenh). 127:7-12.
7. Lu PW, Cowell CT, Jimenez M, Simpson JM, Silink M. 1991 Effect of obesity on endogenous secretion of growth hormone in Turner's syndrome. Arch Dis Child. 66:1184-1190.
8. Foster CM, Borondy M, Markovs ME, Hopwood NJ, Kletter GB, Beitins IZ. 1994 Growth hormone bioactivity in girls with Turner's syndrome: correlation with insulin-like growth factor I. Pediatr Res. 35:218-222.
9. Blethen SL, Albertsson Wikland K, Faklis EJ, Chasalow FI. 1994 Circulating growth hormone isoforms in girls with Turner's syndrome. J Clin Endocrinol Metab. 78:1439-1443.
10. Veldhuis JD, Iranmanesh A, Ho KK, Waters MJ, Johnson ML, Lizarralde G. 1991 Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab. 72:51-59.
11. Williams T, Berelowitz M, Joffe SN, et al. 1984 Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. N Engl J Med. 311:1403-1407.
12. Rasmussen MH, Hvidberg A, Juul A, et al. 1995 Massive weight loss restores 24-h growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects. J Clin Endocrinol Metab. 80:1407-1415.
13. Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on the 24-h profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
14. Iranmanesh A, Lizarralde G, Veldhuis JD. 1991 Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 73:1081-1088.
15. Weltman A, Weltman JY, Hartman ML, et al. 1994 Relationship between age, percentage body fat, fitness, and 24-h growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab. 78:543-548.
16. Vahl N, Jørgensen JO, Jurik AG, Christiansen JS. 1996 Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults. J Clin Endocrinol Metab. 81:2209-2215.
17. Weltman A, Weltman JY, Schurrer R, Evans WS, Veldhuis JD, Rogol AD. 1992 Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity. J Appl Physiol. 72:2188-2196.
18. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L. 1972 Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab. 35:665-670.
19. Zadik Z, Chalew SA, McCarter Jr RJ, Meistas M, Kowarski AA. 1985 The influence of age on the 24-h integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab. 60:513-516.
20. Frantz AG, Rabkin MT. 1965 Effects of estrogen and sex difference on secretion of human growth hormone. J Clin Endocrinol Metab. 25:1470-1480.
21. Veldhuis JD, Liem AY, South S, et al. 1995 Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 80:3209-3222.
22. Murphy DG, Allen G, Haxby JV, et al. 1994 The effects of sex steroids, and the X chromosome, on female brain function: a study of the neuropsychology of adult Turner syndrome. Neuropsychologia. 32:1309-1323.
23. Naeraa RW, Brixen K, Hansen RM, et al. 1991 Skeletal size and bone mineral content in Turner's syndrome: relation to karyotype, estrogen treatment, physical fitness, and bone turnover. Calcif Tissue Int. 49:77-83.
24. Sylven L, Hagenfeldt K, Brondum NK, von Schoultz B. 1991 Middle-aged women with Turner's syndrome. Medical status, hormonal treatment and social life. Acta Endocrinol (Copenh). 125:359-365.
25. Weissberger AJ, Ho KK, Lazarus L. 1991 Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-h growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in post-menopausal women. J Clin Endocrinol Metab. 72:374-381.
26. Heitmann BL. 1990 Prediction of body water and fat in adult Danes from measurement of electrical impedance. A validation study. Int J Obes. 14:789-802.
27. Åstrand I. 1960 A method for prediction of aerobic work capacity for females and males of different ages. Acta Physiol Scand. 49(Suppl 169):45-60.
28. Lindgarde F, Saltin B. 1981 Daily physical activity, work capacity and glucose tolerance in lean and obese normoglycaemic middle-aged men. Diabetologia. 20:134-138.
29. Grimby G, Danneskiold Samsoe B, Hvid K, Saltin B. 1982 Morphology and enzymatic capacity in arm and leg muscles in 78-81 year old men and women. Acta Physiol Scand. 115.125-134.
30. Frystyk J, Skjaerbaek C, Dinesen B, Ørskov H. 1994 Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett. 348:185-191.
31. Andersen L, Dinesen B, Jørgensen PN, Poulsen F, Roder ME. 1993 Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem. 39:578-582.
32. Fisker S, Frystyk J, Skriver L, Vestbo E, Ho KY, Ørskov H. 1996 A simple, rapid immunometric assay for determination of functional and growth hormone-occupied growth hormone-binding protein in human serum. Eur J Clin Invest. 26:779-785.
33. Martha Jr PM, Gorman KM, Blizzard RM, Rogol AD, Veldhuis JD. 1992 Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass. J Clin Endocrinol Metab. 74:336-344.
34. Jensen J, Christiansen C, Rødbro P. 1986 Oestrogen-progestogen replacement therapy changes body composition in early post-menopausal women. Maturitas. 8:209-216.
35. Rebuffe Scrive M, Lonnroth P, Marin F, Wesslau C, Bjorntorp P, Smith U. 1987 Regional adipose tissue metabolism in men and postmenopausal women. Int J Obes. 11:347-355.
36. Haarbo J, Marslew U, Gotfredsen A, Christiansen C. 1991 Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism. 40:1323-1326.
37. Rebuffe Scrive M, Eldh J, Hafstrom LO, Bjorntorp P. 1986 Metabolism of mammary, abdominal, and femoral adipocytes in women before and after menopause. Metabolism. 35:792-797.
38. Phillips SK, Rook KM, Siddle NC, Bruce SA, Woledge RC. 1993 Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy. Clin Sci Colch. 84:95-98.
39. Jørgensen JO, Pedersen SB, Børglum J, et al. 1995 Serum concentrations of insulin-like growth factors (IGFs), IGF binding proteins 1 and 3 and growth hormone binding protein in obese women and the effects of growth hormone administration: a double-blind, placebo-controlled study. Eur J Endocrinol. 133:65-70.
40. Lee PD, Conover CA, Powell DR. 1993 Regulation and function of insulin-like growth factor-binding protein-1. Proc Soc Exp Biol Med. 204:4-29.
41. Belgorosky A, Scorticati C, Rivarola MA. 1983 Sex hormone binding globulin in arterial, and in peripheral, hepatic, renal and spermatic venous blood of children and adults. Acta Endocrinol (Copenh). 103:428-432.
42. Kottler ML, Counis R, Degrelle H. 1989 Sex steroid-binding protein: identification and comparison of the primary product following cell-free translation of human and monkey (Macaca fascicularis) liver RNA. J Steroid Biochem. 33:201-207.
43. Toscano V, Balducci R, Bianchi P, Guglielmi R, Mangiantini A, Sciarra F. 1992 Steroidal and non-steroidal factors in plasma sex hormone binding globulin regulation. J Steroid Biochem Mol Biol. 43:431-437.
44. Holly JM, Smith CP, Dunger DB, et al. 1989 Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-1. A synchronized approach to pubertal development? Clin Endocrinol (Oxf). 31:277-84.
45. Rudd BT, Rayner PH, Thomas PH. 1986 Observations on the role of GH/IGF-1 and sex hormone binding globulin (SHBG) in the pubertal development of growth hormone deficient (GHD) children. Acta Endocrinol (Copenh). 279(Suppl):164-169.
46. Fisker S, Vahl N, Jørgensen JO, Christiansen JS, Ørskov H. 1997 Abdominal fat determines growth hormone binding protein levels in healthy non-obese adults. J Clin Endocrinol Metab. 82:123-128.
47. Dastot F, Sobrier M-L, Duquesnoy P, Duriez B, Goossens M, Amselem S. 1996 Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-ginding protein. Proc Natl Acad Sci USA. 93:10723-10728.
48. Kelly JJ, Rajkovic IA, O'Sullivan AJ, Sernia C, Ho KK. 1993 Effects of different oral oestrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol (Oxf). 39:561-567.
49. Cuttler L, Van Vliet G, Conte FA, Kaplan SL, Grumbach MM. 1985 Somatomedin-C levels in children and adolescents with gonadal dysgenesis: differences from age-matched normal females and effect of chronic estrogen replacement therapy. J Clin Endocrinol Metab. 60:1087-1092.
50. Ross JL, Cassorla FG, Skerda MC, Valk IM, Loriaux DL, Cutler GBJ. 1983 A preliminary study of the effect of estrogen dose on growth in Turner's syndrome. N Engl J Med. 309:1104-1106.
51. Wiedemann E, Schwartz E, Frantz AG. 1976 Acute and chronic estrogen effects upon serum somatomedin activity, growth hormone, and prolactin in man. J Clin Endocrinol Metab. 42:942-952.
52. Chetkowski RJ, Meldrum DR, Steingold KA, et al. 1986 Biologic effects of transdermal estradiol. N Engl J Med. 314:1615-1620.
53. Brown DM, Jowsey J, Bradford DS. 1974 Osteoporosis in ovarian dysgenesis. J Pediatr. 84:816-820.
54. Shore RM, Chesney RW, Mazess RB, Rose PG, Bargman GJ. 1982 Skeletal demineralization in Turner's syndrome. Calcif Tissue Int. 34:519-522.
55. Binnerts A, Swart GR, Wilson JH, et al. 1992 The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf). 37:79-87.
56. Burman P, Broman JE, Hetta J, et al. 1995 Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. J Clin Endocrinol Metab. 80:3585-3590.