Effects of haloperidol on ventilation during isocapnic hypoxia in humans

Journal of Applied Physiology

Volumn 83, Issue 4, 1997, Pages 1110-1115

  Pedersen, Michala E F ^a   Dorrington, Keith L ^a   Robbins, Peter A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acute hypoxic ventilatory response; Dopamine; Hypoxic ventilatory decline

Indexed keywords

DOPAMINE RECEPTOR; HALOPERIDOL;

ADULT; AKATHISIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG VENTILATION; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030752178     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.4.1110     Document Type: Article

References (26)

1. Bainbridge, C. W., and D. D. Heistad. Effect of haloperidol on ventilatory responses to hypoxia in man. J. Pharmacol. Exp. Ther. 213: 13-17, 1980.
2. Bascom, D. A., I. D. Clement, K. L. Dorrington, and P. A. Robbins. Effects of dopamine and domperidone on ventilation during isocapnic hypoxia in humans. Respir. Physiol. 85: 319-328, 1991.
3. Bonora, M., and H. Gautier. Influence of dopamine and norepinephrine on the central ventilatory response to hypoxia in conscious cats. Respir. Physiol. 71: 11-24, 1988.
4. Chow, C. M., C. Winder, and D. J. Read. Influences of endogenous dopamine on carotid body discharge and ventilation. J. Appl. Physiol. 60: 370-375, 1986.
5. Dahan, A. D., D. Ward, M. Van den Elsen, J. Temp, and A. Berkenbosch. Influence of reduced carotid body drive during sustained hypoxia on hypoxic depression of ventilation in humans. J. Appl. Physiol. 81: 565-572, 1996.
6. Delpierre, S., M. Fornaris, C. Guillot, and C. Grimaud. Increased ventilatory chemosensitivity induced by domperidone, a dopamine antagonist, in healthy humans. Bull. Eur. Physiopath. Respir. 23: 31-35, 1987.
7. Easton, P. A., L. J. Slykerman, and N. R. Anthonisen. Ventilatory response to sustained hypoxia in normal adults. J. Appl. Physiol. 61: 906-911, 1986.
8. Foo, I. T., S. E. Martin, R. J. Lee, G. B. Drummond, and P. M. Warren. Interaction of domperidone and sub-anaesthetic concentrations of isoflurane on the immediate and sustained hypoxic ventilatory response in humans. Br. J. Anaesth. 74: 134-140, 1995.
9. Froemming, J. S., Y. W. F. Lam, M. W. Jann, and C. M. Davis. Pharmacokinetics of haloperidol. Clin. Pharmacokinet. 17: 396-423, 1989.
10. Howson, M. G., S. Khamnei, M. E. McIntyre, D. F. O'Connor, and P. A. Robbins. A rapid computer-controlled binary gas-mixing system for studies in respiratory control (Abstract). J. Physiol. (Lond.) 394: 7P, 1987.
11. Javaheri, S., and L. F. Guerra. Effects of domperidone and medroxyprogesterone acetate on ventilation in man. Respir. Physiol. 81: 359-370, 1990.
12. Khot, V., C. L. DeVane, E. R. Korpi, D. Venable, L. B. Bigelow, R. J. Wyatt, and D. G. Kirch. The assessment and clinical implications of haloperidol acute dose, steady-state, and withdrawal pharmacokinetics. J. Clin. Psychopharmacol. 13: 120-127, 1993.
13. Long, W. Q., G. G. Giesbrecht, and N. K. Anthonisen. Ventilatory response to moderate hypoxia in awake chemodenervated cats. J. Appl. Physiol. 74: 805-810, 1993.
14. Neubauer, J. A., J. E. Melton, and N. H. Edelman. Modulation of respiration during brain hypoxia. J. Appl. Physiol. 68: 441-451, 1990.
15. Niemi, M., and K. Ojala. Cytochemical demonstration of catecholamines in the human carotid body. Nature 212: 834-835, 1966.
16. Olsen, L. G., M. J. Hensley, and N. A. Saunders. Augmentation of ventilatory response to asphyxia by prochlorperazine in humans. J. Appl. Physiol. 53: 637-643, 1982.
17. Robbins, P. A. Hypoxic ventilatory decline: site of action. J. Appl. Physiol. 79: 373-374, 1995.
18. Robbins, P. A., G. D. Swanson, A. J. Micco, and W. P. Schubert. A fast gas-mixing system for breath-to-breath respiratory control studies. J. Appl. Physiol. 52: 1358-1362, 1982.
19. Sabol, S. J., and D. S. Ward. Effect of dopamine on hypoxichypercapnic interaction in humans. Anesth. Analg. 66: 619-24, 1987.
20. Steele, R. H., and H. Hinterberger. Catecholamines and 5-hydroxytryptamine in the carotid body in vascular, respiratory, and other diseases. J. Lab. Clin. Med. 80: 63-70, 1972.
21. Tatsumi, K., C. K. Pickett, and J. V. Weil. Effects of haloperidol and domperidone on ventilatory roll off during sustained hypoxia in cats. J. Appl. Physiol. 72: 1945-1952, 1992.
22. Ward, D. S. Stimulation of hypoxic ventilatory drive by droperidol. Anesth. Analg. 63: 106-110, 1984.
23. Ward, D. S. The role of the peripheral D-2 dopamine receptors in hypoxic ventilatory response. In: Concepts and Formalizations in the Control of Breathing, edited by G. Benchitrit, P. Baconnier, and J. Demongeot. Manchester, UK: Manchester Univ. Press, 1987, p. 157-163.
24. Ward, D. S., and J. W. Bellville. Reduction of hypoxic ventilatory drive by dopamine. Anesth. Analg. 61: 333-337, 1982.
25. Ward, D. S., and M. Nino. The effects of dopamine on the ventilatory response to sustained hypoxia in humans. In: Control of Breathing and Its Modelling Perspective, edited by Y. Honda, Y. Miyamoto, K. Konno, and J. D. Widdicombe. New York: Plenum, 1992, p. 291-298.
26. Welsh, M. J., D. D. Heistad, and F. M. Abboud. Effect of dopamine on ventilation in man. J. Clin. Invest. 61: 708-713, 1978.