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Volumn 22, Issue 4, 1997, Pages 386-390

T-588. Cognition enhancer

Author keywords

[No Author keywords available]

Indexed keywords

1 (BENZO[B]THIEN 5 YL) 2 (2 DIETHYLAMINOETHOXY)ETHANOL; ACETYLCHOLINE; CYCLIC AMP; DOPAMINE; NERVE GROWTH FACTOR; NOOTROPIC AGENT; NORADRENALIN; PHOSPHATIDYLINOSITIDE; SEROTONIN; UNCLASSIFIED DRUG;

EID: 0030751265     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (28)
  • 1
    • 0028839373 scopus 로고
    • Studies on cognitive enhancing agents. III. Antiamnestic and antihypoxic activities of a series of 1-bicycloaryl-2-(omega-aminoalkoxy)ethanols
    • Ono, S., Yamafuji, T., Chaki, H., Morita, H., Todo, Y., Okada, N., Maekawa, M., Kitamura, K., Tai, M., Narita, H. Studies on cognitive enhancing agents. III. Antiamnestic and antihypoxic activities of a series of 1-bicycloaryl-2-(omega-aminoalkoxy)ethanols. Chem Pharm Bull 1995, 43: 1492-6.
    • (1995) Chem Pharm Bull , vol.43 , pp. 1492-1496
    • Ono, S.1    Yamafuji, T.2    Chaki, H.3    Morita, H.4    Todo, Y.5    Okada, N.6    Maekawa, M.7    Kitamura, K.8    Tai, M.9    Narita, H.10
  • 4
    • 0029620841 scopus 로고
    • A new cognition-enhancing agent. (R)-(-)1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions
    • Ono, S., Yamafuji, T., Chaki, H., Todo, Y., Maekawa, M., Kitamura, K., Kimura, T., Nakada, Y., Mozumi, K., Narita, H. A new cognition-enhancing agent. (R)-(-)1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions. Biol Pharm Bull 1995, 18: 1779-83.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1779-1783
    • Ono, S.1    Yamafuji, T.2    Chaki, H.3    Todo, Y.4    Maekawa, M.5    Kitamura, K.6    Kimura, T.7    Nakada, Y.8    Mozumi, K.9    Narita, H.10
  • 9
    • 1842284240 scopus 로고
    • Effects of T-588, a novel cognitive enhancer, on various amnesia models in rodents
    • Abst P-639
    • Maekawa, M., Ono, S., Imada, C., Ano, M., Hiraiwa, T., Narita, H. Effects of T-588, a novel cognitive enhancer, on various amnesia models in rodents. Jpn J Pharmacol 1994, 64(Suppl. 1): Abst P-639.
    • (1994) Jpn J Pharmacol , vol.64 , Issue.1 SUPPL.
    • Maekawa, M.1    Ono, S.2    Imada, C.3    Ano, M.4    Hiraiwa, T.5    Narita, H.6
  • 11
    • 0001166630 scopus 로고
    • Effects of a cognitive enhancer, T-588, on place learning deficits and brain activity changes in rats with transient forebrain ischemia
    • Abst 71.14
    • Nakada, Y., Tabuchi, E., Fukuda, M., Torii, K., Ono, T. Effects of a cognitive enhancer, T-588, on place learning deficits and brain activity changes in rats with transient forebrain ischemia. Soc Neurosci Abst 1995, 21(Part 1): Abst 71.14.
    • (1995) Soc Neurosci Abst , vol.21 , Issue.1 PART
    • Nakada, Y.1    Tabuchi, E.2    Fukuda, M.3    Torii, K.4    Ono, T.5
  • 12
    • 1842316673 scopus 로고
    • Effect of T-588 on working memory deficit induced by scopolamine or transient cerebral ischemia
    • Abst P3-201
    • Kurimoto, H., Ono, S., Miyazaki, H., Kimura, T., Narita, H. Effect of T-588 on working memory deficit induced by scopolamine or transient cerebral ischemia. Jpn J Pharmacol 1995, 67(Suppl. 1): Abst P3-201.
    • (1995) Jpn J Pharmacol , vol.67 , Issue.1 SUPPL.
    • Kurimoto, H.1    Ono, S.2    Miyazaki, H.3    Kimura, T.4    Narita, H.5
  • 13
    • 0027297787 scopus 로고
    • Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia
    • Ono, S., Kitamura, K., Maekawa, M., Hirata, K., Ano, M., Ukai, W., Yamafuji, T., Narita, H. Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia. Jpn J Pharmacol 1993, 62: 81-6.
    • (1993) Jpn J Pharmacol , vol.62 , pp. 81-86
    • Ono, S.1    Kitamura, K.2    Maekawa, M.3    Hirata, K.4    Ano, M.5    Ukai, W.6    Yamafuji, T.7    Narita, H.8
  • 14
    • 1842268597 scopus 로고
    • Protective effect of T-588, a novel cognitive enhancer, against experimental anoxia
    • Abst P-638
    • Hirata, K., Ono, S., Kitamura, K., Maekawa, M., Ano, M., Ukai, W., Hiraiwa, T., Narita, H. Protective effect of T-588, a novel cognitive enhancer, against experimental anoxia. Jpn J Pharmacol 1994, 64(Suppl. 1): Abst P-638.
    • (1994) Jpn J Pharmacol , vol.64 , Issue.1 SUPPL.
    • Hirata, K.1    Ono, S.2    Kitamura, K.3    Maekawa, M.4    Ano, M.5    Ukai, W.6    Hiraiwa, T.7    Narita, H.8
  • 15
    • 1842305230 scopus 로고
    • Effect of T-588, a novel cognitive enhancer, on scopolamine-induced EEG slowing
    • Abst P3-200
    • Miyazaki, H., Ono, S., Hoki, S., Narita, H. Effect of T-588, a novel cognitive enhancer, on scopolamine-induced EEG slowing. Jpn J Pharmacol 1995, 67(Suppl. 1): Abst P3-200.
    • (1995) Jpn J Pharmacol , vol.67 , Issue.1 SUPPL.
    • Miyazaki, H.1    Ono, S.2    Hoki, S.3    Narita, H.4
  • 16
    • 1842352331 scopus 로고
    • Effect of T-588, a novel cognitive enhancer, on motor activity in rats
    • Abst P3-217
    • Kozasa, C., Ono, S., Narita, H. Effect of T-588, a novel cognitive enhancer, on motor activity in rats. Jpn J Pharmacol 1995, 67(Suppl. 1): Abst P3-217.
    • (1995) Jpn J Pharmacol , vol.67 , Issue.1 SUPPL.
    • Kozasa, C.1    Ono, S.2    Narita, H.3
  • 17
    • 0008905931 scopus 로고
    • Effects of newly developed T-588 on hippocampus of the rat, in vitro and in vivo studies
    • Abst 507.17
    • Kimura, T., Ono, T., Kobayashi, T., Fukuda, M., Ono, S. Effects of newly developed T-588 on hippocampus of the rat, in vitro and in vivo studies. Soc Neurosci Abst 1993, 19(Part 2): Abst 507.17.
    • (1993) Soc Neurosci Abst , vol.19 , Issue.2 PART
    • Kimura, T.1    Ono, T.2    Kobayashi, T.3    Fukuda, M.4    Ono, S.5
  • 18
    • 1842381308 scopus 로고    scopus 로고
    • Protective effects of T-588, a novel cognition enhancer, on beta-amyloid protein, serum deprivation and glutamate induced neurotoxicity in primary rat hippocampal neurons and cerebellar granule cells
    • Abst P-650
    • Iwakami, N., Yamaguchi, H., Ono, S., Narita, H. Protective effects of T-588, a novel cognition enhancer, on beta-amyloid protein, serum deprivation and glutamate induced neurotoxicity in primary rat hippocampal neurons and cerebellar granule cells. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-650.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.1 SUPPL.
    • Iwakami, N.1    Yamaguchi, H.2    Ono, S.3    Narita, H.4
  • 19
    • 0001140840 scopus 로고
    • Effects of T-588, a novel cognitive enhancer, on acetylcholine and monoamine releases and second-messenger systems in rats
    • Abst 377.2
    • Ono, S., Maekawa, M., Kimura, T., Takagi, A., Nakamura, A., Kondo, K., Miyazaki, H., Mozumi, K., Matsui, N., Narita, H. Effects of T-588, a novel cognitive enhancer, on acetylcholine and monoamine releases and second-messenger systems in rats. Soc Neurosci Abst 1995, 21 (Part 2): Abst 377.2.
    • (1995) Soc Neurosci Abst , vol.21 , Issue.2 PART
    • Ono, S.1    Maekawa, M.2    Kimura, T.3    Takagi, A.4    Nakamura, A.5    Kondo, K.6    Miyazaki, H.7    Mozumi, K.8    Matsui, N.9    Narita, H.10
  • 20
    • 1842323392 scopus 로고    scopus 로고
    • Effects of T-588, a novel cognitive enhancer, on efflux of acetylcholine and monoamine in rat brain
    • Abst P-457
    • Maekawa, M., Ono, S., Mozumi, K., Miyazaki, H., Hirata, K., Narita, H. Effects of T-588, a novel cognitive enhancer, on efflux of acetylcholine and monoamine in rat brain. Jpn J Pharmacol 1996, 71(Suppl. 1): Abst P-457.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.1 SUPPL.
    • Maekawa, M.1    Ono, S.2    Mozumi, K.3    Miyazaki, H.4    Hirata, K.5    Narita, H.6
  • 21
    • 0344869269 scopus 로고
    • The actions of T-588, a novel cognitive enhancer, on noradrenaline release in rat cerebral cortical slices
    • Abst 257.17
    • Miyazaki, H., Murayama, T., Ono, S., Narita, H., Nomura, Y. The actions of T-588, a novel cognitive enhancer, on noradrenaline release in rat cerebral cortical slices. Soc Neurosci Abst 1995, 21(1-3): Abst 257.17.
    • (1995) Soc Neurosci Abst , vol.21 , Issue.1-3
    • Miyazaki, H.1    Murayama, T.2    Ono, S.3    Narita, H.4    Nomura, Y.5
  • 22
    • 1842269541 scopus 로고    scopus 로고
    • The effects of T-588, a novel cognitive enhancer, on noradrenaline uptake and release in rat cerebral cortical slices
    • Abst P-236
    • Maekawa, M., Miyazaki, H., Murayama, T., Ono, S., Narita, H., Nomura, Y. The effects of T-588, a novel cognitive enhancer, on noradrenaline uptake and release in rat cerebral cortical slices. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-236.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.1 SUPPL.
    • Maekawa, M.1    Miyazaki, H.2    Murayama, T.3    Ono, S.4    Narita, H.5    Nomura, Y.6
  • 23
    • 1842313839 scopus 로고    scopus 로고
    • Effect of T-588, a novel cognitive enhancer, on NGF-induced neunte outgrowth in PC12 cells
    • Abst P-649
    • Yamaguchi, H., Ono, S., Hirata, K., Narita, H. Effect of T-588, a novel cognitive enhancer, on NGF-induced neunte outgrowth in PC12 cells. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-649.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.1 SUPPL.
    • Yamaguchi, H.1    Ono, S.2    Hirata, K.3    Narita, H.4
  • 24
    • 1842390005 scopus 로고    scopus 로고
    • Effect of T-588, a novel cognitive enhancer, on Pl-hydrolysis in rat brain slices
    • Abst P-458
    • Kondo, K., Ono, S., Miyazaki, H., Moriuchi, T., Mozumi, K., Matsui, N., Narita, H. Effect of T-588, a novel cognitive enhancer, on Pl-hydrolysis in rat brain slices. Jpn J Pharmacol 1996, 71 (Suppl. 1): Abst P-458.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.1 SUPPL.
    • Kondo, K.1    Ono, S.2    Miyazaki, H.3    Moriuchi, T.4    Mozumi, K.5    Matsui, N.6    Narita, H.7
  • 25
    • 1842347416 scopus 로고    scopus 로고
    • Effects of T-588, a novel cognitive enhancer, on cyclic AMP formation in rat brain slices
    • Abst P-459
    • Takagi, A., Ono, S., Nakamura, A., Narita, H. Effects of T-588, a novel cognitive enhancer, on cyclic AMP formation in rat brain slices. Jpn J Pharmacol 1996, 71 (Suppl. 1): Abst P-459.
    • (1996) Jpn J Pharmacol , vol.71 , Issue.1 SUPPL.
    • Takagi, A.1    Ono, S.2    Nakamura, A.3    Narita, H.4
  • 26
    • 1842391013 scopus 로고    scopus 로고
    • Pharmacological characterization of T-588, a novel cognitive enhancer, on cyclic AMP formation in rat brain slices
    • Abst P-367
    • Nakamura, A., Ono, S., Takagi, A., Shoji, M., Narita, H. Pharmacological characterization of T-588, a novel cognitive enhancer, on cyclic AMP formation in rat brain slices. Jpn J Pharmacol 1997, 73(Suppl. 1): Abst P-367.
    • (1997) Jpn J Pharmacol , vol.73 , Issue.1 SUPPL.
    • Nakamura, A.1    Ono, S.2    Takagi, A.3    Shoji, M.4    Narita, H.5
  • 27
    • 1842312866 scopus 로고    scopus 로고
    • Toyama Chemical Co., Ltd. Annual Report 1996
    • Toyama Chemical Co., Ltd. Annual Report 1996.


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