Genomic sequence analysis of a key residue (Arg183) in human Gα(q) in invasive non-functional pituitary adenomas

Clinical Endocrinology

Volumn 47, Issue 2, 1997, Pages 241-244

  Farrell, W E ^a   Talbot, J A ^a   Bicknell, E J ^a   Simpson, D ^a   Clayton, R N ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PHOSPHOLIPASE C; PROTEIN KINASE C; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ALLELE; ARTICLE; DNA SEQUENCE; FIBROBLAST; GENOME; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; INTRON; ONCOGENE; PRIORITY JOURNAL; PSEUDOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

EID: 0030751174     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.2891088.x     Document Type: Article

References (29)

1. Alexander, J.M., Biller, B.M.K., Bikkal, H., Zervas, N.T., Arnold, A. & Klibanski, A. (1990) Clinically Nonfunctioning Pituitary Tumors Are Monoclonal in Origin. Journal of Clinical Investigation, 86, 336-340.
2. Alvaro, V., Touraine, P., Raisman, V., Baigrenier, F., Birman, P. & Joubert, D. (1992) Protein kinase C activity and expression in normal and adenomatous human pituitaries. International Journal of Cancer, 50, 724-730.
3. Alvaro, V., Levy, L., Dubray, C., Roche, A., Peillon, F., Querat, B. & Joubert, D. (1993) Invasive pituitary tumours express a point mutated α-protein kinase-C. Journal of Clinical Endocrinology and Metabolism, 77, 1125-1129.
4. Bates, A.S., Farrell, W.E., Bicknell, J., Buckley, N., Talbot, J.A., Broome, J.C., Perrett, C.W., Thakker, R.V. & Clayton, R.N. (1997) Genetic instability in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. Journal of Clinical Endocrinology and Metabolism, 82, 818-824.
5. Boggild, M.D., Jenkinson, S., Pistorello, M., Boscaro, M., Scanarini, M., McTernan, P., Perrett, C.W., Thakker, R.V. & Clayton, R.N. (1994) Molecular mechanisms of pituitary tumour formation; evidence of genetic heterogeneity tumour initiation. Journal of Clinical Endocrinology and Metabolism, 78, 387-392.
6. Borner, C., Filipuzzi, I., Weinstein, I.B. & Imber, R. (1991) Failure of wild type or a mutant form of protein kinase Ca to transform fibroblasts. Nature, 353, 78-80.
7. Bystrom, C., Larsson, C., Blomberg, C., Sandelin, K., Falkmer, E., Skogseid, B., Oberg, B., Werner, S. & Nordenskjold, M. (1990) Localisation of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumours. Proceedings of the National Academy of Sciences of the USA, 87, 1968-1972.
8. Conklin, B.R., Chabre, O., Wong, Y.H., Federman, A.D. & Bourne, H.R. (1992) Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. Journal of Biological Chemistry, 267, 31-34.
9. De Vivo, M., Chen, J., Codina, J. & Iyengar, R. (1992) Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209L-alpha-subunits. Journal of Biological Chemistry, 267, 18263-18266.
10. De Vivo, M. & Iyengar, R. (1994) Activated Gqα potentiates platelet-derived growth factor-stimulated mitogenesis in confluent cell cultures. Journal of Biological Chemistry, 269, 19671-19674.
11. q Gene (GNAQ) and a processed pseudogene. Genomics, 30, 470-475.
12. s, or Thyrotropin-Releasing Hormone Receptor Genes. Journal of Clinical Endocrinology and Metabolism, 81, 1134-1140.
13. Gupta, S.K., Gallego, C., Lowndes, J.M., Pleiman, C.M., Sable, C., Eisfelder, B.J. & Johnson, G.L. (1992) Analysis of the fibroblast transforming potential of GTPase deficient oncogenes. Molecular and Cellular Biology, 12, 190-197.
14. Hardy, J. (1979) Transphenoidal microsurgical treatment of pituitary tumours. In: (Linfoot, J., ed.) Recent advances in the diagnosis and treatment of pituitary tumours. pp. 375-388, Raven Press, New York.
15. Herman, V., Fagin, J., Gonsky, R., Kovacs, K., Melmed, S. (1990) Clonal origin of pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 71, 1427-1433.
16. 2 protein have opposite effects on the proliferation of NIH3T3 cells. Proceedings of the National Academy of Sciences of the United States of America, 88, 10455-10459.
17. Jameson, J.L., Klibanski, A., Black, P., McL., Zervas, N.T., Lindell, C.M., Hsu, D.W., Ridgway, E.C. & Habener, J.F. (1987) Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. Journal Clinical Investigation, 80, 1472-1478.
18. Kalinec, G., Nazarali, A.J., Hermouet, S., Xu, N. and Gutkind, J.S. (1992) Mutated alpha subunits of the Gq protein induces malignant transformation in NIH 3T3 cells. Molecular and Cellular Biology, 12, 4687-4693.
19. Landis, C.A., Masters, S.B., Spada, A., Pace, A.M., Bourne, H.R. & Vallar, L. (1990) GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenyl cyclase in human pituitary tumours. Nature, 340, 692-696.
20. 2 induces neoplastic transformation in RAT-1 cells. Proceedings of the National Academy of Sciences of the United Stales of America, 88, 7031-7035.
21. Seuwen, K. & Pouyssegur, J. (1992) G protein-controlling signal transduction pathways and the regulation of cell proliferation. Adv Cancer Research, 58, 75-94.
22. Smrcka, A.V., Hepler, J.R., Brown, K.O. & Sternweis, P.C. (1991) Regulation of polyphosphoinisitide-specific phospholipase C activity by purified Gq. Science, 251, 804-807.
23. Stephens, E.V., Kalinec, G., Brann, M.R. & Gutkind, J. (1993) Transforming G protein coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent of cAMP inhibition or conventional protein kinase C. Oncogene, 8, 19-26.
24. Strathmann, M. & Simon, M.I. (1990) G protein diversity: A distinct class of α subunits is present in vertebrates and invertebrates. Proceedings of the National Academy of Sciences of the United States of America, 87, 9113-9117.
25. Thakker, R.V., Pook, M.A., Wooding, C., Boscaro, M., Scanarini, M. & Clayton, R.N. (1993) Association of Somatotrophinomas with Loss of Alleles on Chromosome 11 and with gsp Mutations. Journal of Clinical Investigation, 91, 2815-2821.
26. Tordjman, K., Stern, N., Ouaknine, G., Yossiphov, Y., Razon, N., Nordenskjold, M. & Friedman, E. (1993) Activating mutations of the Gsα-gene in non functioning pituitary tumours. Journal of Clinical Endocrinology and Metabolism, 1993, 77, 765-769.
27. Vallar, L., Spada, A. & Giannattasio, G. (1987) Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature, 1971, 330, 566-568.
28. 2α mutations in clinically non-functioning pituitary tumours. Clinical Endocrinology, 41, 815-820.
29. Wu, D.Q., Lee, C.H., Rhee, S.G. & Simon, M.I. (1992) Activation of phospholipase C by the alpha subunit of the Gq and G11 protein in transfected Cos-7 cells. Journal of Biological Chemistry, 267, 1811-1817.